Browsing Conditions by Title
Now showing items 617-636 of 698
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The tail wagging the dog: the diagnostic accuracy of first rank symptoms COMMENTARY ON… COCHRANE CORNER
(2019-10)Outcomes for people with schizophrenia are improved by expedient diagnosis and specific treatment. ICD-11 and DSM-5 have reduced the importance of Schneider's first rank symptoms (FRS) in the diagnosis of schizophrenia; ... -
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A targeted psychological treatment for sleep problems in young people at ultra-high risk of psychosis in England (SleepWell): a parallel group, single-blind, randomised controlled feasibility trial
(2023-08)Sleep disturbance is common and problematic for young people at ultra-high risk of psychosis. Sleep disruption is a contributory causal factor in the occurrence of mental health problems, including psychotic experiences, ... -
Targeting beliefs and behaviours in misophonia: a case series from a UK specialist psychology service
(2023-10)Background: Misophonia, a disorder of decreased sound tolerance, can cause significant distress and impairment. Cognitive behavioural therapy (CBT) may be helpful for improving symptoms of misophonia, but the key mechanisms ... -
Targeting synaptic plasticity in schizophrenia: insights from genomic studies
(2021-08)Recent genomic findings identify many hundreds of genomic loci that are associated with schizophrenia. Consistent with data from the pregenomic era, genomic findings implicate synaptic function and plasticity as a tractable ... -
Technology Matters: BlueIce – using a smartphone app to beat adolescent self‐harm
(2020-06)Despite the recent proliferation of mental health apps, few have directly focused on the prevention of self-harm. The available apps are described and the limited, although encouraging, outcome data are summarised. The ... -
The Temporal Dynamics of Sleep Disturbance and Psychopathology in Psychosis: A Digital Sampling Study
(2020-12)Background: Sleep disruption is a common precursor to deterioration and relapse in people living with psychotic disorders. Understanding the temporal relationship between sleep and psychopathology is important for identifying ... -
Ten misconceptions about trauma-focused CBT for PTSD
(2022-04)Therapist cognitions about trauma-focused psychological therapies can affect our implementation of evidence-based therapies for posttraumatic stress disorder (PTSD), potentially reducing their effectiveness. Based on ... -
Testing the combination of Feeling Safe and peer counselling against formulation-based cognitive behaviour therapy to promote psychological wellbeing in people with persecutory delusions: study protocol for a randomized controlled trial (the Feeling Safe-NL Trial)
(2023-10)Persecutory delusions are strong threat beliefs about others’ negative intentions. They can have a major impact on patients’ day-to-day life. The Feeling Safe Programme is a new translational cognitive-behaviour therapy ... -
The theory-practice gap in wound care: effective ways of embedding your learning into clinical practice
(2020-12)It has been suggested that there are approximately 2.2 million patients in the UK with a chronic wound (Guest et al, 2016). The cost of managing these wounds and associated comorbidities is approximately £5.3 billion (Guest ... -
Therapist-assisted online psychological therapies differing in trauma focus for post-traumatic stress disorder (STOP-PTSD): a UK-based, single-blind, randomised controlled trial
(2023-08)Many patients are currently unable to access psychological treatments for post-traumatic stress disorder (PTSD), and it is unclear which types of therapist-assisted internet-based treatments work best. We aimed to investigate ... -
Third external replication of an individualised transdiagnostic prediction model for the automatic detection of individuals at risk of psychosis using electronic health records
(2021-02)Primary indicated prevention is a key target for reducing the incidence and burden of schizophrenia and related psychotic disorders. An individualised, clinically-based transdiagnostic model for the detection of individuals ... -
Time to focus more on promoting mental health than treating mental illness
(2018-03)Mental health problems are a major contributor to overall burden of disease worldwide. In UK, it represents up to 23% of the total burden of disease - the largest single cause of disability. To build a healthier, more ... -
The times they are a-changin’
(2018-07)Editorial: "The first issue of Evidence-Based Mental Health (EBMH) is celebrating the 20th anniversary. Readers were welcomed to EBMH in 1998, which was designed to assist ‘mental health clinicians stay up to date with the ... -
Towards precision in the diagnostic profiling of patients: leveraging symptom dynamics in the assessment of major depressive disorder
(2023-08)Major depressive disorder (MDD) is a heterogeneous mental disorder. International guidelines present overall symptom severity as the key dimension for clinical characterisation. However, additional layers of individual ... -
Trace amine-associated receptor 1 (TAAR1) agonists for psychosis: protocol for a living systematic review and meta-analysis of human and non-human studies.
(2023-08)Background: There is an urgent need to develop more effective and safer antipsychotics beyond dopamine 2 receptor antagonists. An emerging and promising approach is TAAR1 agonism. Therefore, we will conduct a living ... -
Translating the promise of 5HT4 receptor agonists for the treatment of depression
(2020-02)Animal experimental studies suggest that 5-HT4 receptor activation holds promise as a novel target for the treatment of depression and cognitive impairment. 5-HT4 receptors are postsynaptic receptors that are located in ... -
Translating the Strengthening and Stretching for Rheumatoid Arthritis of the Hand Programme from clinical trial to clinical practice: An effectiveness–implementation study
(2020-09)Introduction The Strengthening and Stretching for Rheumatoid Arthritis of the Hand programme is a hand exercise programme for people with rheumatoid arthritis. It was clinically effective when delivered during a clinical ... -
Trauma, mental health and the COVID-19 crisis: are we really all in it together?
(2021-02)As the world adapts to varying levels of social lockdown – and the lifting of restrictions – due to the COVID-19 pandemic, evidence is mounting that quarantine and other social restrictions negatively affect the mental ... -
Treating sleep problems in young people at ultra-high-risk of psychosis: study protocol for a single-blind parallel group randomised controlled feasibility trial (SleepWell).
(2020-11)Background Effective interventions, targeting key contributory causal factors, are needed to prevent the emergence of severe mental health problems in young people. Insomnia is a common clinical issue that is problematic ...