Browsing Conditions by Title
Now showing items 644-663 of 698
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Ultra-processed foods and binge eating: A retrospective observational study
(2021-04)There is increasing evidence of the impact of ultra-processed foods on multiple metabolic and neurobiological pathways, including those involved in eating behaviors, both in animals and in humans. In this study we aimed ... -
Ultradian hydrocortisone replacement alters neuronal processing, emotional ambiguity, affect and fatigue in adrenal insufficiency: The PULSES trial
(2023-10)Background: Primary adrenal insufficiency (PAI) mortality and morbidity remain unacceptably high, possibly arising as glucocorticoid replacement does not replicate natural physiology. A pulsatile subcutaneous pump can ... -
Understanding agoraphobic avoidance: the development of the Oxford Cognitions and Defences Questionnaire (O-CDQ)
(2022-02)Many patients with mental health disorders become increasingly isolated at home due to anxiety about going outside. A cognitive perspective on this difficulty is that threat cognitions lead to the safety-seeking behavioural ... -
Understanding and working with suicide risk
(2015-07)Key learning points: Understanding risk factors associated with suicide; Considering a framework for understanding suicide; How to assess and manage suicide risk -
Understanding clinical decision-making in mesothelioma care: a mixed methods study
(2022-07)Malignant pleural mesothelioma is a rare, incurable cancer arising from previous asbestos exposure; patients have a poor prognosis, with a median survival rate of 8–14 months. Variation in mesothelioma clinical decision-making ... -
Understanding young peoples’ and family members’ views of treatment for first episode psychosis in a randomised controlled trial (MAPS)
(2020-07)Background;There is limited evidence to inform treatment decision-making in adolescents experiencing first episode psychosis (FEP). In the MAPS trial (Managing Adolescent first Episode Psychosis: a feasibility Study), ... -
Understanding, treating, and renaming grandiosedelusions: A qualitative study
(2019-11)Background.Grandiose delusions are arguably the most neglected psychotic experience in research. Objectives.We aimed to discover from patients: whether grandiose delusions have harmful consequences; the psychological ... -
Unraveling Mechanisms of Patient-Specific NRXN1 Mutations in Neuropsychiatric Diseases Using Human Induced Pluripotent Stem Cells
(2020-03)Rare heterozygous deletions in the neurexin 1 (NRXN1) gene robustly increase an individual's risk of developing neurological and psychiatric disorders. However, the molecular bases by which different mutations result in ... -
Unravelling the complex interactions between self-awareness, cognitive change, and mood at 6-months post-stroke using the Y-shaped model
(2022-02)We investigated the relationships between cognitive change following stroke, awareness of cognitive impairments, and mood to further understanding of change processes influencing psychological outcomes post-stroke ... -
Untreatable or unable to treat? Creating more effective and accessible treatment for long-standing and severe eating disorders
(2023-02)The evidence base for the treatment of severe eating disorders is limited. In addition to improving access to early intervention, there is a need to develop more effective treatments for complex presentations of eating ... -
Use and risk of side effects of antiresorptive medication in people with intellectual disabilities [version 1; peer review: awaiting peer review]
(2022-12)Background: Recent studies show that adults with intellectual disabilities (ID) have high incidence of major osteoporotic fracture, especially hip fracture. In those ≥ 50 years, women and men with ID have an approximately ... -
The use of Fox’s glacier mints to treat ibs-type symptoms in patients with anorexia nervosa in an adult specialist eating disorder unit
(2021-03)Background: Patients with Anorexia Nervosa (AN) often experience Irritable Bowel Syndrome (IBS) type symptoms, including bloating, abdominal pain and acid reflux.(1) Pepper mint oil is used to treat IBS symptoms, due to ... -
The use of Intensive Interaction within a Positive Behavioural Support framework
(2021-01)Positive Behavioural Support (PBS) provides an overarching framework for supporting quality‐of‐life improvements for people who use challenging behaviour. Rapport, or the lack of it, is well understood as a setting factor ... -
Using a modified Delphi methodology to gain consensus on the use of dressings in chronic wounds management
(2018-03-06)Objective:Managing chronic wounds is associated with a burden to patients, caregivers, health services and society and there is a lack of clarity regarding the role of dressings in improving outcomes. This study aimed to ... -
Using Computational Psychiatry to Rule Out the Hidden Causes of Depression
(2017-08)In an ideal world, our understanding of the causes of psychiatric disorders would progress by testing mechanistic hypotheses in experimental studies, using the results of these studies to identify situations in which the ... -
Using digital monitoring alongside psychosocial interventions in patients who self-harm
(2021-05)With more than 200,000 presentations to hospital for self-harm each year in England, there is a clear requirement to reduce self-harm and improve well-being in this population. This service evaluation examined the potential ... -
Using the 11-item Version of the RCADS to Identify Anxiety and Depressive Disorders in Adolescents
(2021)The purpose of this study was to identify items from the Revised Children’s Anxiety and Depression Scale – RCADS-C/P that provided a brief, reliable and valid screen for anxiety and/or depressive disorders in adolescents. ... -
Using therapy outcome measures to identify the speech and language therapy needs of children and young people with severe acquired brain injury
(2022-12)Children and young people often require speech and language therapy input following severe acquired brain injury. However, there is limited understanding of the impact of post-acute neurorehabilitation on children and young ... -
Validation of the UK English Oxford Cognitive Screen-Plus in Sub-Acute and Chronic Stroke Survivors.
(2022-06)Stroke survivors are routinely screened for cognitive impairment with tools that often fail to detect subtle impairments. The Oxford Cognitive Screen-Plus (OCS-Plus) is a brief tablet-based screen designed to detect subtle ... -
A validation study to trigger nicotine craving in virtual reality
(2022-04)We built a virtual beer garden that contained various smoking cues (both verbal and non-verbal) using a motion capture system to record the realistic smoking behaviour related animations. Our 3-min long VR experience was ...