Conditions, Lifestyle Factors & Interventions
Recent Submissions
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Vascular disease and multiple sclerosis: a post-mortem study exploring their relationships
(2020-09)Vascular comorbidities have a deleterious impact on multiple sclerosis clinical outcomes but it is unclear whether this is mediated by an excess of extracranial vascular disease (i.e. atherosclerosis) and/or of cerebral ... -
The effect of a youth mental health service model on access to secondary mental healthcare for young people aged 14–25 years
(2018-09)Aims and method The Norfolk Youth Service was created in 2012 in response to calls to redesign mental health services to better meet the needs of young people. The new service model transcends traditional boundaries by ... -
School- and class-level variation in self-harm, suicide ideation and suicide attempts in Danish high schools.
(2018-09)AIM: Strong associations have been found between being exposed to self-harm in family and friends and own self-harm in adolescence. Therefore, self-harm and suicide behaviour might tend to cluster within school and school ... -
A Dissociation of the Acute Effects of Bupropion on Positive Emotional Processing and Reward Processing in Healthy Volunteers
(2018-10)Background: Previous research indicates that antidepressants can restore the balance between negative and positive emotional processing early in treatment, indicating a role of this effect in later mood improvement. However, ... -
Affective bias as a rational response to the statistics of rewards and punishments
(2017-10)Affective bias, the tendency to differentially prioritise the processing of negative relative to positive events, is commonly observed in clinical and non-clinical populations. However, why such biases develop is not known. ... -
Symptom trajectories in discontinuation trials.
(2017-02)Many patients with clinical depression, particularly those with recurrent illness, are treated with maintenance antidepressants after an acute-phase response. But how effective is this approach? The effectiveness of ... -
Using Computational Psychiatry to Rule Out the Hidden Causes of Depression
(2017-08)In an ideal world, our understanding of the causes of psychiatric disorders would progress by testing mechanistic hypotheses in experimental studies, using the results of these studies to identify situations in which the ... -
Effect of Prefrontal Cortex Stimulation on Regulation of Amygdala Response to Threat in Individuals With Trait Anxiety A Randomized Clinical Trial
(2019-01)Importance Transcranial direct current stimulation (tDCS) of the dorsolateral prefrontal cortex (DLPFC) is under clinical investigation as a treatment for major depressive disorder. However, the mechanisms of action are ... -
Predicting Treatment Response to Antidepressant Medication Using Early Changes in Emotional Processing.
(2019-01)Antidepressants must be taken for weeks before response can be assessed with many patients not responding to the first medication prescribed. This often results in long delays before effective treatment is started. ... -
Self-harm on roads: Register-based study of methods and characteristics of individuals involved
(2020-12)Background Suicide on roads is receiving increased attention. However, there has been little research on non-fatal road-related self-harm. This study was conducted in order to investigate the characteristics of such ... -
Cognitive appraisals of dissociation in psychosis: a new brief measure
(2020-12)Background: Catastrophic cognitive appraisals, similar to those in anxiety disorders, are implicated in depersonalisation, a form of dissociation. No scales exist to measure appraisals of dissociative experiences. ... -
Anticipatory Pleasure in Current Psychosis: Cognitive and Emotional Correlates
(2020-12)Anticipation of pleasure – a key aspect of hedonic experience - is a motivating factor for engaging in activities. Low levels of anticipatory pleasure and activity are found in individuals with psychosis. Cognitive factors ... -
Be there on time: Spatial-temporal regularities guide young children’s attention in dynamic environments
(2020-12)It is believed that children have difficulties in guiding attention while facing distraction. However, developmental accounts of spatial attention rely on traditional search designs using static displays. ... -
Replay bursts in humans coincide with activation of the default mode and parietal alpha networks
(2020-12)Replay in humans coincides with activity in specific resting brain networks Clusters of heightened default mode and alpha activity are linked to replay bursts These networks are characterized by highly synchronized ... -
An exploration of ending psychotherapy: The experiences of volunteer counsellors
(2020-12)Background/aims Literature suggests that the ending phase of therapy can be difficult and challenging for counsellors. Despite this, there is limited research in this area and no study has specifically looked at the ... -
Are benzodiazepines effective in treating catatonia?
(2020-12)Establishing an evidence base for the clinical management of catatonia is made difficult by the heterogeneous nature of the condition and the limited understanding of its pathophysiology. Benzodiazepines are a mainstay of ... -
Risk, demand and capacity in adult specialist eating disorder services in the South of England – before and since Covid-19
(2020-12)Aims and Method: This is a longitudinal cohort study describing the demand and capacity for specialist inpatient treatment of patients with severe eating disorders covering a population of 3.5 million. We compared the ... -
Do parent factors predict early weight gain in family therapy for anorexia nervosa? Revisiting variables in a community treatment sample
(2020-12)Objective: It is unclear why some children and adolescents respond well to family therapy for anorexia nervosa (AN) and others do not. Previous exploratory studies have suggested that parent variables may be important ... -
Phase 1/2 trial of SARS-CoV-2 vaccine ChAdOx1 nCoV-19 with a booster dose induces multifunctional antibody responses
(2020-12)More than 190 vaccines are currently in development to prevent infection by the novel severe acute respiratory syndrome coronavirus 2. Animal studies suggest that while neutralizing antibodies against the viral spike protein ... -
Glucocorticoid ultradian rhythmicity differentially regulates mood and resting state networks in the human brain: A randomised controlled clinical trial
(2021-02)Adrenal glucocorticoid secretion into the systematic circulation is characterised by a complex rhythm, composed of the diurnal variation, formed by changes in pulse amplitude of an underlying ultradian rhythm of short ...
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