Conditions, Lifestyle Factors & Interventions
Recent Submissions
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Are current guidelines overcautious regarding refeeding of patients with severe anorexia nervosa: a retrospective cohort study
(2020-05)Weight restoration is an integral part of managing anorexia nervosa patients and has been found to be associated with electrolyte and fluid abnormalities gathered under the umbrella term refeeding syndrome, which has led ... -
The Western diet: a blind spot of eating disorder research?—a narrative review and recommendations for treatment and research
(2020-07)Over the last 50 years, in parallel with the obesity epidemic, the prevalence of eating disorders has increased and presentations have changed. In this narrative review, we consider recent research exploring the implications ... -
Ultra-processed foods and binge eating: A retrospective observational study
(2021-04)There is increasing evidence of the impact of ultra-processed foods on multiple metabolic and neurobiological pathways, including those involved in eating behaviors, both in animals and in humans. In this study we aimed ... -
Evolutionary Perspectives on Eating Disorders
(2022-09)The focus of this chapter is on evolutionary theories and models of anorexia nervosa (AN), bulimia nervosa (BN) and obesity. Although obesity is not considered a mental health problem, its link with binge eating disorder ... -
EATING DISORDERS: AGE OF ONSET AND ITS ASSOCIATED GENETIC RISK FACTORS
(2022-09)The age at which an eating disorder begins to develop has important implications for the design of services and the targeting of clinical interventions. Eating disorders have a heritability of 16-83% and a median age ... -
Characterization of the central nervous system penetrant and selective purine P2X7 receptor antagonist JNJ-54175446 in patients with major depressive disorder
(2023-07)JNJ-54175446 is a selective purine P2X7 receptor (P2X7R) antagonist that attenuates microglial IL-1β/IL-18 release. In healthy volunteers, JNJ-54175446 suppressed peripheral interleukin (IL)-1β release, and attenuated ... -
Nasogastric tube feeding under restraint: understanding the impact and improving care
(2023-07)Nasogastric tube feeding under physical restraint is an intervention that clinicians working in specialist mental health in-patient units may need to implement. Aims To examine the impact of this intervention on people ... -
Effects of ulotaront on brain circuits of reward, working memory, and emotion processing in healthy volunteers with high or low schizotypy
(2023-08)Ulotaront, a trace amine-associated receptor 1 (TAAR1) and serotonin 5-HT1A receptor agonist without antagonist activity at dopamine D2 or the serotonin 5-HT2A receptors, has demonstrated efficacy in the treatment of ... -
A targeted psychological treatment for sleep problems in young people at ultra-high risk of psychosis in England (SleepWell): a parallel group, single-blind, randomised controlled feasibility trial
(2023-08)Sleep disturbance is common and problematic for young people at ultra-high risk of psychosis. Sleep disruption is a contributory causal factor in the occurrence of mental health problems, including psychotic experiences, ... -
Effect of selective serotonin reuptake inhibitor treatment following diagnosis of depression on suicidal behaviour risk: a target trial emulation
(2023-07)There is concern regarding the impact of selective serotonin reuptake inhibitors (SSRIs) on suicidal behaviour. Using the target trial framework, we investigated the effect on suicidal behaviour of SSRI treatment following ... -
Service evaluation of multi-family therapy for anorexia groups between 2013–2021 in a specialist child and adolescent eating disorders service
(2023-07)The aims of the service evaluation were to examine the effectiveness of multi-family therapy for anorexia nervosa (MFT-AN) on family relationships, as well as to understand families’ experiences of MFT in a specialist child ... -
Disentangling the Consequences of Systemic Racism and Clinical Paranoia to Promote Effectiveness of a Cognitive-Behavioral Intervention for Persecutory Delusions in Minoritized Individuals: A Case-Example
(2023-07)While everyone experiences threats, some threats are culturally specific and not universally recognized or addressed by providers. A prominent example is threat-based worry and hypervigilance in Black Americans and other ... -
Therapist-assisted online psychological therapies differing in trauma focus for post-traumatic stress disorder (STOP-PTSD): a UK-based, single-blind, randomised controlled trial
(2023-08)Many patients are currently unable to access psychological treatments for post-traumatic stress disorder (PTSD), and it is unclear which types of therapist-assisted internet-based treatments work best. We aimed to investigate ... -
Cognitive Behavioural Therapy for Psychosis
(2023-04)Cognitive behavioural therapy for psychosis (CBTp) is an evidence-based and flexible therapeutic approach to support clients to meet their goals. The appraisal of anomalous experiences, such as voice hearing, is given a ... -
Aripiprazole in autism spectrum disorder: current evidence for use
(2023-04)This month's Cochrane Corner meta-analysis evaluates the evidence for the use of aripiprazole in ‘autism spectrum disorders’ – although in fact, outcome measures mainly included subtypes of challenging behaviour and ... -
A randomised controlled test of emotional attributes of a virtual coach within a virtual reality (VR) mental health treatment
(2023-07)We set out to test whether positive non-verbal behaviours of a virtual coach can enhance people's engagement in automated virtual reality therapy. 120 individuals scoring highly for fear of heights participated. In a ... -
Getting Better: How Well Are We Assessing and Managing Anxiety Disorders in Community Camhs?
(2023-07)Anxiety disorders are a common presenting problem for young people under the care of Melksham Community CAMHS. Guidelines from NICE outline recommendations for best practice in assessment and treatment of these disorders. ... -
Developing a virtual reality environment for educational and therapeutic application to investigate psychological reactivity to bullying
(2023-07)Understanding how bullying victimisation influences cognitive and emotional processes may help to direct early intervention to prevent the development of psychopathology. In a convenience sample of 67 female adolescents, ... -
Actigraphy-derived physical activity levels and circadian rhythm parameters in patients with psoriatic arthritis: relationship with disease activity, mood, age and BMI
(2023-07)Background: Psoriatic arthritis (PsA) is associated with sleep disturbance, depression and a lifetime risk of obesity and cardiovascular disease. To date, there have been no studies investigating the relationship between ...
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