Conditions, Lifestyle Factors & Interventions
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Effectiveness of Vitamin D Supplementation in the Management of Multiple Sclerosis: A Systematic Review
(2019-03)Objective: to examine the extent of effect vitamin D in Multiple Sclerosis (MS) on pathology and symptoms. Methods: A literature search was performed in November 2018 (CRD42018103615). Eligibility criteria: randomised ... -
Barriers and facilitators to implementing dementia care mapping in care homes: results from the DCM™ EPIC trial process evaluation
(2019-02)Background: Psychosocial person-centred interventions are considered best practice for addressing complex behaviours and care needs such as agitation and anxiety, and for improving the quality of life of people with ... -
Development and validation of a prediction model for the probability of responding to placebo in antidepressant trials: a pooled analysis of individual patient data
(2019)Background: Identifying potential placebo responders among apparent drug responders is critical to dissect drug-specific and nonspecific effects in depression. Objective: This project aimed to develop and test a prediction ... -
A single dose of fluoxetine reduces neural limbic responses to anger in depressed adolescents
(2019-01-21)Depression in adolescence is frequently characterised by symptoms of irritability. Fluoxetine is the antidepressant with the most favourable benefit:risk ratio profile to treat adolescent depression, but the neural ... -
The experience of feeling fat for women with anorexia nervosa: An interpretative phenomenological analysis
(2019-01)Feeling fat has been implicated as a maintenance factor in anorexia nervosa (AN), despite limited research into the experience. This study expanded the literature by exploring the lived experience of feeling fat for ... -
Strengthening Attachment Competencies in Parents with Mental Illness: Adaptation and Pilot Testing of the Mentalization-Based Lighthouse Parenting Program
(2019-01-01)Strengthening Attachment Competencies in Parents with Mental Illness: Adaptation and Pilot Testing of the Mentalization-Based Lighthouse Parenting Program Mentalizing describes the imaginative ability to understand human ... -
Comparative economic evaluation of quetiapine plus lamotrigine combination vs quetiapine monotherapy (and folic acid vs placebo) in patients with bipolar depression (cequel)
(2018-12)Although not licensed for acute bipolar depression, lamotrigine has evidence for efficacy in trials and its use is recommended in guidelines. So far there had been no prospective health economic evaluation of its use. ... -
Chronic psychosocial stressors are associated with alterations in salience processing and corticostriatal connectivity.
(2018-12-17)Psychosocial stressors including childhood adversity, migration, and living in an urban environment, have been associated with several psychiatric disorders, including psychotic disorders. The neural and psychological ... -
A signature-based machine learning model for distinguishing bipolar disorder and borderline personality disorder
(2018)Mobile technologies offer new opportunities for prospective, high resolution monitoring of long-term health conditions. The opportunities seem of particular promise in psychiatry where diagnoses often rely on retrospective and ... -
The effects of incretin‐based therapies on β‐cell function and insulin resistance in type 2 diabetes: A systematic review and network meta‐analysis combining 360 trials
(2018-12-09)Aim To evaluate the comparative effects of incretin‐based therapies, including glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) and dipeptidyl peptidase‐4 inhibitors (DPP‐4Is), on β‐cell function and insulin resistance ... -
Vitamin D, bone mineral density and risk of fracture in people with intellectual disabilities
(2018-12)Background: People with intellectual disabilities (IDs) have very high rates of osteoporosis and fractures, to which their widespread vitamin D deficiency and other factors could contribute. We aimed to assess in people ... -
Vortioxetine for depression: the evidence for its current use in the UK: COMMENTARY ON… COCHRANE CORNER
(2018-12-17)The pharmacological treatment of depression is often hampered by side-effects and unsatisfactory response to treatment. Vortioxetine is one of the newest antidepressants on the market, purportedly with a different mechanism ... -
Changes in brain Glx in depressed bipolar patients treated with lamotrigine: A proton MRS study
(2019-03)Background Lamotrigine is a useful treatment in bipolar depression but requires several weeks of dose titration before its clinical effects can be assessed. Animal experimental studies suggest that lamotrigine lowers ... -
The WHELD programme: showing the benefits
(2019-01)The WHELD study demonstrates that with support home care teams can incorporate into practice a focused approach to person centred care, augmented with other therapeutic elements of personalised social activities and ... -
A web-based clinical decision tool to support treatment decision-making in psychiatry: a pilot focus group study with clinicians, patients and carers
(2017)Background Treatment decision tools have been developed in many fields of medicine, including psychiatry, however benefits for patients have not been sustained once the support is withdrawn. We have developed a web-based ... -
The Role of Self-Management Practices as Mechanisms for Re-Establishing Normality in Cancer Survivors
(2016)This article explores the relationship between cancer survivors' use of self-management practices and their search for normality. Using Frank's illness narratives and other theoretical literature on normality in chronic ... -
Care needs of people with dementia in the peri-operative environment: A systematic review
(2018-11)The care of people with dementia within the hospital setting is challenging for healthcare professionals. Hospital design and services are not optimized for people with dementia, owing to the lack of preparation of healthcare ... -
Psychiatric disorders, substance use, and executive functioning in older probationers
(2018-11)Abstract Background: Although the number of older people serving community sentences (probation) after conviction for a criminal offence in England and Wales has increased rapidly since about 2006, this population has ... -
Lighthouse Parenting Programme: Description and pilot evaluation of Mentalization-Based Treatment (MBT) to address child maltreatment.
(2019)This paper introduces an innovative Mentalization - Based Treatment (MBT) parenting intervention for families where children are at risk of maltreatment. The Lighthouse MBT Parenting Programme aims to prevent child ... -
Why reviewing apps is not enough: Transparency for Trust (T4T): The Principles of Responsible Mental Health App Marketplaces
(2018)Digital therapeutics are being touted as having the potential to transform healthcare by improving people’s experience, increasing effectiveness, and reducing costs. A few digital aids are recommended and integral to ...
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