Conditions, Lifestyle Factors & Interventions
Recent Submissions
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Musculoskeletal complications following critical illness: A scoping review
(2021-08)Purpose To explore the extent to which musculoskeletal (MSK) complications have been reported following critical illness, identifying evidence gaps and providing recommendations for future research. Materials and methods We ... -
The knowns and unknowns of SSRI treatment in young people with depression and anxiety: efficacy, predictors, and mechanisms of action
(2021-08)The use of SSRIs for the treatment of depression and anxiety in young people is increasing. However, the effects of SSRIs in adolescence, a time when there are substantial changes in neural, cognitive, and social functioning, ... -
Appraisal of patient-level health economic models of severe mental illness: systematic review
(2021-08)Healthcare decision makers require accurate long-term economic models to evaluate the cost-effectiveness of new mental health interventions. Aims To assess the suitability of current patient-level economic models to ... -
Effect of lithium on circadian rhythm in bipolar disorder: A systematic review and meta-analysis
(2021-03)Circadian rhythm disruption is commonly reported in patients with bipolar disorder. Lithium has been suggested to have effects on the circadian clock, the biological basis of the circadian rhythm. The objective of the ... -
Toward a neurobiology of internal selective attention
(2021-07)A recent study in non-human primates (NHPs) by Panichello and Buschman brings the investigation of selective attention within visual working memory to the systems and cellular neuroscience levels. We reflect on this ... -
Digitally supported CBT to reduce paranoia and improve reasoning for people with schizophrenia-spectrum psychosis: the SlowMo RCT
(2021-08)Background: Reasoning may play a causal role in paranoid delusions in psychosis. SlowMo, a new digitally supported cognitive–behavioural therapy, targets reasoning to reduce paranoia. Objectives: To examine the effectiveness ... -
Targeting synaptic plasticity in schizophrenia: insights from genomic studies
(2021-08)Recent genomic findings identify many hundreds of genomic loci that are associated with schizophrenia. Consistent with data from the pregenomic era, genomic findings implicate synaptic function and plasticity as a tractable ... -
How Efficacious Are Antipsychotic Drugs for Schizophrenia? An Interpretation Based on 13 Effect Size Indices
(2021-08)Background The magnitude of the superiority of antipsychotics over placebo is debated. One reason is that the effect-size index which is usually used in meta-analyses is in standard deviation units. Many other indices, ... -
An Experimental Medicine Investigation of the Effects of Subacute Pramipexole Treatment on Emotional Information Processing in Healthy Volunteers
(2021-08)Treatment with the dopamine D2/D3 receptor agonist pramipexole has demonstrated promising clinical effects in patients with depression. However, the mechanisms through which pramipexole might alleviate depressive symptoms ... -
Online peer support training to promote adolescents’ emotional support skills, mental health and agency during COVID-19: A pilot randomised controlled trial
(2021-08)Background: Adolescents often look to their peers for emotional support, so it is critical that they are prepared to take on a supportive role, especially during a health crisis. Using a pilot randomised controlled trial ... -
Effectiveness of gait aid prescription for improving spatiotemporal gait parameters and associated outcomes in community-dwelling older people: a systematic review
(2021-07)Purpose To integrate the evidence of gait aid prescription for improving spatiotemporal gait parameters, balance, safety, adherence to gait aid use, and reducing falls in community-dwelling older people. Methods Seven ... -
Risk Factors for Mobility Decline in Community-Dwelling Older Adults: A Systematic Literature Review
(2021-08)Mobility is essential to maintaining independence for older adults. This systematic review aimed to summarize evidence about self-reported risk factors for self-reported mobility decline; and to provide an overview of ... -
A Computational View on the Nature of Reward and Value in Anhedonia
(2021-08)Anhedonia—a common feature of depression—encompasses a reduction in the subjective experience and anticipation of rewarding events, and a reduction in the motivation to seek out such events. The presence of anhedonia often ... -
Public mental health and nature: a paradigm shift
(2021-08)Purpose Drawing on experience of working in the area of mental health and the environment, key issues are examined, and the theoretical framework is explained, including the benefits to communities and to the local ... -
A service evaluation of short-term mentalisation based treatment for personality disorder
(2021-08)Background People with personality disorder experience long waiting times for access to psychological treatments, resulting from a limited availability of long-term psychotherapies and a paucity of evidence-based brief ... -
Multi-scale neural signatures of major depressive, anxiety, and stress-related disorders
(2021-07)The extent of shared and distinct neural mechanisms underlying major depressive disorder (MDD), anxiety and stress-related disorders is still unclear. We compared the neural signatures of these disorders in 5,405 UK Biobank ... -
Elevated iron concentration in putamen and cortical speech motor network in developmental stuttering.
(2021-07)Theoretical accounts of developmental stuttering implicate dysfunctional cortico-striatalthalamo-cortical motor loops through the putamen. Analysis of conventional MRI brain scans in people who stutter has failed to yield ... -
Parenting an Autistic Child: Experiences of Parents with Significant Autistic Traits
(2021-07)Despite autism being highly heritable, this study is the first to investigate the experiences of parents of autistic children who have significant autistic traits themselves. Eight parents of autistic children with significant ... -
COVID-19 vaccine hesitancy in systemic sclerosis
(2021-07)In conclusion, our survey suggests that most patients with SSc have positive feelings towards COVID-19 vaccine, but uncertainties are present in a considerable proportion of cases. These results highlight the crucial ... -
Incidence and outcomes of eating disorders during the COVID-19 pandemic
(2021-07)There are concerns that eating disorders have become commoner during the coronavirus disease 2019 (COVID-19) pandemic. Using the electronic health records of 5.2 million people aged under 30, mostly in the USA, we show ...
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