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Prolonged Grief and Posttraumatic Stress Disorder Following the Loss of a Significant Other: An Investigation of Cognitive and Behavioural Differences
(2020-01)Cognitive behavioural correlates to bereavement-related mental health problems such a Prolonged Grief Disorder (PGD) and Posttraumatic Stress Disorder (PTSD) are of theoretical and clinical importance. Methods:Individuals ... -
Patterns in Weight and Physical Activity Tracking Data Preceding a Stop in Weight Monitoring: Observational Analysis
(2020-03)Background: Self-regulation for weight loss requires regular self-monitoring of weight, but the frequency of weight tracking commonly declines over time. Objective: This study aimed to investigate whether it is a decline ... -
Effective psychological treatment for PTSD changes the dynamics of specific large-‐scale brain networks
(2020-01)Very little is known about the role of effective cognitive therapy in reversing imbalances in brain activity after trauma. We hypothesised that exaggerated threat perception characteristic of p ... -
Effect of the NMDA receptor partial agonist, d-cycloserine, on emotional processing and autobiographical memory
(2020-04)Background: Studies suggest that d-cycloserine (DCS) may have antidepressant potential through its interaction with the glycine site of the N-Methyl-D-aspartate receptor (NMDAR); however clinical evidence of DCS’s efficacy ... -
Translating the promise of 5HT4 receptor agonists for the treatment of depression
(2020-02)Animal experimental studies suggest that 5-HT4 receptor activation holds promise as a novel target for the treatment of depression and cognitive impairment. 5-HT4 receptors are postsynaptic receptors that are located in ... -
Cognitive Performance, Quality and Quantity of Movement Reflect Psychological Symptoms in Adolescents
(2020-05)The presentation of unhealthy psychological symptoms are rising sharply in adolescents. Detrimental lifestyle behaviours are proposed as both possible causes and consequences. This study set out to compare selected ... -
Pharmacological Treatments for Social Anxiety Disorder in Adults: A Systematic Review and Network Meta-Analysis
(2020-02)Objective: The aim of this paper was to provide a systematic review and update on the pharmacotherapy of social anxiety disorder (SAD), including the efficacy and tolerability of these agents, the ranking of interventions, ... -
Methotrexate and relative risk of dementia amongst patients with rheumatoid arthritis: a multi-national multi-database case-control study
(2020-04)Background Inflammatory processes have been shown to play a role in dementia. To understand this role, we selected two anti-inflammatory drugs (methotrexate and sulfasalazine) to study their association with dementia ... -
Efficacy and acceptability of pharmacological and non-pharmacological interventions for non-specific chronic low back pain: a protocol for a systematic review and network meta-analysis.
(2020-06)Background Despite the enormous financial and humanistic burden of chronic low back pain (CLBP), there is little consensus on what constitutes the best treatment options from a multitude of competing interventions. The ... -
Sleep disruption after brain injury is associated with worse motor outcomes and slower functional recovery.
(2020-02)Background and Aims: Sleep is important for consolidation of motor learning, but brain injury may affect sleep continuity and therefore rehabilitation outcomes. This study aims to assess the relationship between sleep ... -
Stress, inflammation and hippocampal subfields in depression: A 7 Tesla MRI Study
(2020-02)Experiencing stressful events throughout one’s life, particularly childhood trauma, increases the likelihood of being diagnosed with Major Depressive Disorder (MDD). Raised levels of cortisol, and markers of inflammation ... -
Why do patients with psychosis listen to and believe derogatory and threatening voices? 2 21 reasons given by patients
(2020-05)Background: Around two thirds of patients with auditory hallucinations experience derogatory 37 and threatening voices (DTVs). Understandably, when these voices are believed then common 38 consequences can be depression, ... -
Examination of the neural basis of psychotic-like experiences in adolescence during processing of emotional faces
(2020-03)Contemporary theories propose that dysregulation of emotional perception is involved in the aetiology of psychosis. 298 healthy adolescents were assessed at age 14- and 19-years using fMRI while performing a facial emotion ... -
Does repeatedly viewing overweight versus underweight images change perception of and satisfaction with own body size?
(2020-04)Body dissatisfaction is associated with subsequent eating disorders and weight gain. One-off exposure to bodies of different sizes changes perception of others' bodies, and perception of and satisfaction with own body size. ... -
Evaluating the Feasibility of Frequent Cognitive Assessment Using the Mezurio Smartphone App: Observational and Interview Study in Adults With Elevated Dementia Risk
(2020-04)Background: By enabling frequent, sensitive, and economic remote assessment, smartphones will facilitate the detection of early cognitive decline at scale. Previous studies have sustained participant engagement with remote ... -
Cognitive therapy for post-traumatic stress disorder following critical illness and intensive care unit admission
(2020-04)Around a quarter of patients treated in intensive care units (ICUs) will develop symptoms of Post-Traumatic Stress Disorder (PTSD). Given the dramatic increase in ICU admissions during the COVID-19 pandemic, post-ICU PTSD ... -
How representative are neuroimaging samples? Large-scale evidence for trait anxiety differences between MRI and behaviour-only research participants.
(2020-04)Over the past three decades, MRI has become a key tool to study how cognitive processes are implemented in the human brain. However, the question of whether participants recruited into MRI studies differ from participants ... -
Why sleep matters for young people who may get depressed
(2020-04)Depression and anxiety are negative emotional states familiar to us all through personal experience. Less familiar are severe states of depression, in particular, which can actually shorten the lives of sufferers by over ... -
Building ‘a compassionate armour’: the journey to develop strength and self‐compassion in a group treatment for complex post‐traumatic stress disorder
(2020-04)Objectives. Complex post-traumatic stress disorder (PTSD) is associated with severe difficulties in emotional regulation, interpersonal relationships, and shame. For individuals with these difficulties, exposure-based ...
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