Browsing Conditions by Title
Now showing items 190-209 of 698
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The early impact of the COVID-19 pandemic on patients with severe mental illness: An interrupted time-series study in South-East England
(2022-04)Abstract Background. Deterioration in general population mental health since the start of the COVID-19 pandemic has been reported, but the impact of the pandemic on people with severe mental illness (SMI) has received ... -
The Early Youth Engagement in first episode psychosis (EYE-2) study: pragmatic cluster randomised controlled trial of implementation, effectiveness and cost-effectiveness of a team-based motivational engagement intervention to improve engagement
(2021-04)Background Early Intervention in Psychosis (EIP) services improve health outcomes for young people with psychosis in the medium–long term, but 25% of young people disengage in the first 12 months with costs to their mental ... -
Early- and subsequent- response of cognitive functioning in Alzheimer's disease: Individual-participant data from five pivotal randomized clinical trials of donepezil
(2022-02)The association between early improvement and subsequent change in cognition is unexamined in antidementia clinical trials. We aimed to examine the consequences of early-response to antidementia medication in Alzheimer's ... -
EATING DISORDERS: AGE OF ONSET AND ITS ASSOCIATED GENETIC RISK FACTORS
(2022-09)The age at which an eating disorder begins to develop has important implications for the design of services and the targeting of clinical interventions. Eating disorders have a heritability of 16-83% and a median age ... -
The effect of a genetic variant at the schizophrenia associated AS3MT/BORCS7 locus on striatal dopamine function: A PET imaging study
(2019)One of the most statistically significant loci to result from large-scale GWAS of schizophrenia is 10q24.32. However, it is still unclear how this locus is involved in the pathoaetiology of schizophrenia. The hypothesis ... -
The effect of a youth mental health service model on access to secondary mental healthcare for young people aged 14–25 years
(2018-09)Aims and method The Norfolk Youth Service was created in 2012 in response to calls to redesign mental health services to better meet the needs of young people. The new service model transcends traditional boundaries by ... -
Effect of acute citalopram on self-referential emotional processing and social cognition in healthy volunteers
(2020-10)Background Depression is characterised by negative views of the self. Antidepressant treatment may remediate negative self-schema through increasing processing of positive information about the self. Changes in affective ... -
Effect of Assertive Community Treatment for Patients with Substance Use Disorder: A Systematic Review
(2019-01-30)Substance use disorders (SUD) are an important health issue internationally. Traditional outpatient programmes often do not adequately address the substantial medical and social needs and in addition many patients ... -
Effect of lithium on circadian rhythm in bipolar disorder: A systematic review and meta-analysis
(2021-03)Circadian rhythm disruption is commonly reported in patients with bipolar disorder. Lithium has been suggested to have effects on the circadian clock, the biological basis of the circadian rhythm. The objective of the ... -
The effect of overweight/obesity on diastolic function in children and adolescents: A meta-analysis
(2021-06)Left ventricular diastolic function (LVDF) is an important marker of early cardiovascular remodelling, which has not been well summarized in young people with overweight/ obesity. Weighted, random-effects regression was ... -
Effect of point of care blood testing on physical health check completion in mental health services: mixed-methods evaluation
(2020-10)Physical health outcomes in severe mental illness are worse than in the general population. Routine physical health check completion in this group is poor. Aims To quantitatively and qualitatively evaluate the impact of ... -
Effect of Prefrontal Cortex Stimulation on Regulation of Amygdala Response to Threat in Individuals With Trait Anxiety A Randomized Clinical Trial
(2019-01)Importance Transcranial direct current stimulation (tDCS) of the dorsolateral prefrontal cortex (DLPFC) is under clinical investigation as a treatment for major depressive disorder. However, the mechanisms of action are ... -
Effect of selective serotonin reuptake inhibitor treatment following diagnosis of depression on suicidal behaviour risk: a target trial emulation
(2023-07)There is concern regarding the impact of selective serotonin reuptake inhibitors (SSRIs) on suicidal behaviour. Using the target trial framework, we investigated the effect on suicidal behaviour of SSRI treatment following ... -
Effect of serial awake prone positioning on oxygenation in patients admitted to intensive care with COVID-19
(2021-04)Introduction Awake prone positioning (APP) might benefit patients with COVID-19 by improving oxygenation, but it is unknown whether this improvement can be sustained with serial proning episodes. Methods We conducted ... -
The effect of sertraline on emotional processing: secondary analyses of the PANDA randomised controlled trial
(2021-01)Background. According to the cognitive neuropsychological model, antidepressants reduce symptoms of depression and anxiety by increasing positive relative to negative information processing. Most studies of whether ... -
Effect of the NMDA receptor partial agonist, d-cycloserine, on emotional processing and autobiographical memory
(2020-04)Background: Studies suggest that d-cycloserine (DCS) may have antidepressant potential through its interaction with the glycine site of the N-Methyl-D-aspartate receptor (NMDAR); however clinical evidence of DCS’s efficacy ... -
Effect of trazodone on cognitive decline in people with dementia: Cohort study using UK routinely collected data
(2021-09)Evidence in mouse models has found that the antidepressant trazodone may be protective against neurodegeneration. We therefore aimed to compare cognitive decline of people with dementia taking trazodone with those taking ... -
Effective psychological treatment for PTSD changes the dynamics of specific large-‐scale brain networks
(2020-01)Very little is known about the role of effective cognitive therapy in reversing imbalances in brain activity after trauma. We hypothesised that exaggerated threat perception characteristic of p ... -
Effectiveness and Acceptability of Cognitive Behavior Therapy Delivery Formats in Adults With Depression A Network Meta-analysis
(2019-04)Importance Cognitive behavior therapy (CBT) has been shown to be effective in the treatment of acute depression. However, whether CBT can be effectively delivered in individual, group, telephone-administered, guided ... -
The Effectiveness and Feasibility of Psychological Interventions for Populations Under Ongoing Threat: A Systematic Review
(2023-03)Current views of psychological therapies for trauma typically assume the traumatic event to be in the past. Yet, individuals who live in contexts of ongoing organized violence or experience intimate partner violence (IPV) ...