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    Targeting synaptic plasticity in schizophrenia: insights from genomic studies

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    Date
    2021-08
    Author
    Hall, Nicola A
    Tunbridge, Elizabeth
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    Citation
    Arne W. Mould, Nicola A. Hall, Ira Milosevic, Elizabeth M. Tunbridge, Targeting synaptic plasticity in schizophrenia: insights from genomic studies, Trends in Molecular Medicine, 2021
    Abstract
    Recent genomic findings identify many hundreds of genomic loci that are associated with schizophrenia. Consistent with data from the pregenomic era, genomic findings implicate synaptic function and plasticity as a tractable therapeutic target for the cognitive dysfunction and negative symptoms that patients experience. Genomic findings have the potential to provide insights into the nature of synaptic dysfunction in schizophrenia, and to identify novel therapeutic targets, but identifying the most promising candidates remains a challenge. We propose an integrated approach to triaging the long list of potential genomic targets and provide six practical criteria that we use to prioritise putative candidates.
    Description
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    URI
    https://oxfordhealth-nhs.archive.knowledgearc.net/handle/123456789/935
    Published online at:
    https://doi.org/10.1016/j.molmed.2021.07.014
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    • Schizophrenia and Psychotic Disorders [86]

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