Browsing Schizophrenia and Psychotic Disorders by Title
Now showing items 81-100 of 101
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The serum metabolomic profile of a distinct, inflammatory subtype of acute psychosis
(2022-09)A range of studies suggest that a proportion of psychosis may have an autoimmune basis, but this has not translated through into clinical practice—there is no biochemical test able to accurately identify psychosis resulting ... -
The service user experience of SlowMo therapy: A co-produced thematic analysis of service users' subjective experience
(2022-04)Objectives: SlowMo is the first blended digital therapy for paranoia, showing significant small-moderate reductions in paranoia in a recent large-scale randomized controlled trial (RCT). This study explored the subjective ... -
The side effect profile of Clozapine in real world data of three large mental hospitals
(2020-01)Objective: Mining the data contained within Electronic Health Records (EHRs) can potentially generate a greater understanding of medication effects in the real world, complementing what we know from Randomised control ... -
Sleep and circadian rhythm actigraphy measures, mood instability and impulsivity: A systematic review
(2021-09)The normal spectrum trait measures of mood instability and impulsivity are implicated in and comprise core symptoms of several psychiatric disorders. A bidirectional relationship between these traits and sleep disturbance ... -
Sleep Disorders in Early Psychosis: Incidence, Severity, and Association With Clinical Symptoms
(2018-09-08)Sleep disturbance is known to be associated with psychosis, but sleep disorders (eg. insomnia, nightmare disorder, sleep apnea) have rarely been investigated. We aimed to provide the first detailed assessment of sleep ... -
Sleep disturbance and psychiatric disorders
(2020-07)Signs of mental ill health that cut across psychiatric diagnostic categories at high rates are typically viewed as non-specific occurrences, downgraded in importance and disregarded. However, problems not associated with ... -
SlowMo therapy, a new digital blended therapy for fear of harm from others: An account of therapy personalisation within a targeted intervention
(2022-01)Objectives: SlowMo therapy is a pioneering blended digital therapy for paranoia, augmenting face-to-face therapy with an interactive ‘webapp’ and a mobile app. A recent largescale trial demonstrated small–moderate effects ... -
Specialised early intervention for recent-onset psychosis
(2022-03)Specialised early intervention (SEI) services have seen significant investment and expansion in the UK, aiming to improve long-term outcomes for psychotic disorders. This commentary discusses a recent Cochrane review that ... -
Study of immunotherapy in antibody positive psychosis: feasibility and acceptability (SINAPPS1)
(2018-06-11)The main finding of the SINAPPS1 study is that immunotherapy can be delivered rapidly and safely to people with acute psychosis within an acute hospital setting. The treatments were tolerated and there were no cases of ... -
Study protocol for a randomised controlled trial of CBT vs antipsychotics vs both in 14–18-year-olds: Managing Adolescent first episode Psychosis: a feasibility study (MAPS)
(2019-07)Background: Adolescent-onset psychosis is associated with more severe symptoms and poorer outcomes than adult-onset psychosis. The National Institute for Clinical Excellence (NICE) recommend that adolescents with first ... -
The tail wagging the dog: the diagnostic accuracy of first rank symptoms COMMENTARY ON… COCHRANE CORNER
(2019-10)Outcomes for people with schizophrenia are improved by expedient diagnosis and specific treatment. ICD-11 and DSM-5 have reduced the importance of Schneider's first rank symptoms (FRS) in the diagnosis of schizophrenia; ... -
Targeting synaptic plasticity in schizophrenia: insights from genomic studies
(2021-08)Recent genomic findings identify many hundreds of genomic loci that are associated with schizophrenia. Consistent with data from the pregenomic era, genomic findings implicate synaptic function and plasticity as a tractable ... -
The Temporal Dynamics of Sleep Disturbance and Psychopathology in Psychosis: A Digital Sampling Study
(2020-12)Background: Sleep disruption is a common precursor to deterioration and relapse in people living with psychotic disorders. Understanding the temporal relationship between sleep and psychopathology is important for identifying ... -
Third external replication of an individualised transdiagnostic prediction model for the automatic detection of individuals at risk of psychosis using electronic health records
(2021-02)Primary indicated prevention is a key target for reducing the incidence and burden of schizophrenia and related psychotic disorders. An individualised, clinically-based transdiagnostic model for the detection of individuals ... -
Understanding young peoples’ and family members’ views of treatment for first episode psychosis in a randomised controlled trial (MAPS)
(2020-07)Background;There is limited evidence to inform treatment decision-making in adolescents experiencing first episode psychosis (FEP). In the MAPS trial (Managing Adolescent first Episode Psychosis: a feasibility Study), ... -
Understanding, treating, and renaming grandiosedelusions: A qualitative study
(2019-11)Background.Grandiose delusions are arguably the most neglected psychotic experience in research. Objectives.We aimed to discover from patients: whether grandiose delusions have harmful consequences; the psychological ... -
Violent outcomes in first-episode psychosis: A clinical cohort study
(2019-11)Aim Violence risk is an important part of a comprehensive clinical assessment in first‐episode psychosis. This study addresses limitations of previous violent outcome research in first‐episode psychosis, which has typically ... -
Virtual reality clinical-experimental tests of compassion treatment techniques to reduce paranoia
(2020-05)Paranoia may build on negative beliefs held both about the self and others. Compassionate imagery may be one way of reducing such negative beliefs, and hence paranoia. Two studies tested this idea, one targeting compassion ... -
The weeks before 100 persecutory delusions: the presence of many potential contributory causal factors
(2019-09)Background:The period before the formation of a persecutory delusion may provide causal insights. Patient accounts are invaluable in informing this understanding. Aims:To inform the understanding of delusion formation, ... -
Weight change, cardio-metabolic risk factors and cardiovascular incidence in people with serious mental illness: protocol of a population-based cohort study in the UK from 1998 to 2020
(2021-11)Introduction: People with serious mental illness (SMI), which includes people with diagnoses of schizophrenia spectrum and bipolar disorders, face significant health inequality. This includes a life expectancy reduced by ...
