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    Now showing items 19-38 of 84

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        Developing an automated VR cognitive treatment for psychosis: gameChange VR therapy 

        Lambe, Sinead; Lister, Rachel; Rosebrock, Laina; Rovira, Aitor; Clark, David M; Freeman, Daniel; Waite, Felicity (2020-04)
        The automated delivery of psychological treatment using virtual reality (VR) has the potential to revolutionise patient access to evidence-based care. VR creates immersive, interactive computer simulations, which elicit ...
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        Development of the Ketamine Side Effect Tool 

        McShane, Rupert (2020-04)
        Background: Currently, no specific, systematic assessment tool for the monitoring and reporting of ketamine-related side effects exists. Our aim was to develop a comprehensive Ketamine Side Effect Tool (KSET) to capture ...
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        Digitally supported CBT to reduce paranoia and improve reasoning for people with schizophrenia-spectrum psychosis: the SlowMo RCT 

        Freeman, Daniel (2021-08)
        Background: Reasoning may play a causal role in paranoid delusions in psychosis. SlowMo, a new digitally supported cognitive–behavioural therapy, targets reasoning to reduce paranoia. Objectives: To examine the effectiveness ...
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        Disrupted‐in‐schizophrenia 1 functional polymorphisms and D2/D3 receptor availability: A [11C]‐(+)‐PHNO imaging study 

        Dahoun, Tarik (2019-07)
        The disrupted‐in‐schizophrenia 1 (DISC1) protein has been implicated in a range of biological mechanisms underlying chronic mental disorders such as schizophrenia. Schizophrenia is associated with abnormal striatal dopamine ...
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        Dissociation in patients with non-affective psychosis: Prevalence, symptom associations, and maintenance factors 

        Cernis, Emma; Molodynski, Andrew; Ehlers, Anke; Freeman, Daniel (2021-11)
        Dissociation is problematic in its own right for patients with psychosis but may also contribute to the occurrence of psychotic experiences. We therefore set out to estimate in a large cohort of patients with psychosis the ...
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        Dissociation in relation to other mental health conditions: An exploration using network analysis 

        Ehlers, Anke; Freeman, Daniel (2020-08)
        Dissociative experiences, traditionally studied in relation to trauma and PTSD, may be important phenomena across many different psychological conditions, including as a contributory causal factor for psychotic experiences. ...
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        Do environmental risk factors for the development of psychosis distribute differently across dimensionally assessed psychotic experiences? 

        Johns, Louise; Goodwin, Guy M (2021-04)
        Psychotic experiences (PE) are associated with poorer functioning, higher distress and the onset of serious mental illness. Environmental exposures (e.g. childhood abuse) are associated with the development of PE. However, ...
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        The Early Youth Engagement in first episode psychosis (EYE-2) study: pragmatic cluster randomised controlled trial of implementation, effectiveness and cost-effectiveness of a team-based motivational engagement intervention to improve engagement 

        Lennox, Belinda; Johns, Louise (2021-04)
        Background Early Intervention in Psychosis (EIP) services improve health outcomes for young people with psychosis in the medium–long term, but 25% of young people disengage in the first 12 months with costs to their mental ...
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        The effect of a genetic variant at the schizophrenia associated AS3MT/BORCS7 locus on striatal dopamine function: A PET imaging study 

        Dahoun, Tarik (2019)
        One of the most statistically significant loci to result from large-scale GWAS of schizophrenia is 10q24.32. However, it is still unclear how this locus is involved in the pathoaetiology of schizophrenia. The hypothesis ...
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        Effect of point of care blood testing on physical health check completion in mental health services: mixed-methods evaluation 

        De Cassan, Simone; Walton, Debbie; Bale, Robert; Lennox, Belinda (2020-10)
        Physical health outcomes in severe mental illness are worse than in the general population. Routine physical health check completion in this group is poor. Aims To quantitatively and qualitatively evaluate the impact of ...
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        Effects of SlowMo, a Blended Digital Therapy Targeting Reasoning, on Paranoia Among People With Psychosis A Randomized Clinical Trial 

        Freeman, Daniel; Collett, Nicola; Rus-Calafell, Mar (2021-04)
        IMPORTANCE Persistent paranoia is common among patients with psychosis. Cognitive-behavioral therapy for psychosis can be effective. However, challenges in engagement and effectiveness remain. OBJECTIVE To investigate ...
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        Efficacy and Acceptability of Interventions for Attenuated Positive Psychotic Symptoms in Individuals at Clinical High Risk of Psychosis: A Network Meta-Analysis 

        Cipriani, Andrea (2018-06-12)
        Background: Attenuated positive psychotic symptoms represent the defining features of the clinical high-risk for psychosis (CHR-P) criteria. The effectiveness of each available treatment for reducing attenuated positive ...
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        Elevated homocysteine and N-methyl-D-aspartate-receptor antibodies as a cause of behavioural and cognitive decline in 22q11.2 deletion syndrome 

        Banerjee, Subimal; Lennox, Belinda (2017-12)
        A 19-year-old male with 22q11.2 deletion syndrome presented with a 4-year history of cognitive decline and symptoms suggestive of atypical psychosis. Potential for elevated homocysteine and NMDA-receptor antibodies in the ...
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        Evidence base for early intervention in psychosis services in rural areas: A critical review 

        Pipkin, Alastair (2020-07)
        Aim: Early Intervention in Psychosis teams (EITs) are a growing entity internationally, yet they remain under-researched given challenges facing their delivery. Model adaptations include stand-alone services, a hub-and-spoke ...
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        Examination of the neural basis of psychotic-like experiences in adolescence during processing of emotional faces 

        External author(s) only (2020-03)
        Contemporary theories propose that dysregulation of emotional perception is involved in the aetiology of psychosis. 298 healthy adolescents were assessed at age 14- and 19-years using fMRI while performing a facial emotion ...
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        Excessive sleepiness in patients with psychosis: An initial investigation 

        Sheaves, Bryony; Freeman, Daniel (2021-01)
        Clinical experience indicates that excessive sleepiness and hypersomnia may be a common issue for patients with psychosis. Excessive sleepiness is typically ascribed to the sedating effects of antipsychotic medications but ...
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        The Experience of Sleep Problems and Their Treatment in Young People at Ultra-High Risk of Psychosis: A Thematic Analysis 

        Waite, Felicity; Bradley, Jonathan; Bird, Jessica C.; Freeman, Daniel (2018-08)
        We view sleep disruption as a contributory causal factor in the development of psychotic experiences. Clinical trials indicate that psychological interventions targeting insomnia result in improvements in both sleep and ...
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        Fear of illness recurrence and mental healthanxiety in people recovering from psychosis andcommon mental health problems 

        Salkovskis, Paul Martin (2020-06)
        Objectives: It is well known that mental health problems can recur even after effective treatment, leading to an understandable fear of illness recurrence (FIR) and mental health anxiety (MHA). These may themselves contribute ...
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        Hebephrenia is dead, long live hebephrenia, or why Hecker and Chaslin were on to something 

        Barrera, Alvaro; Curwell-Parry, Owen (2019-05-03)
        Since its first description in 1863, ‘hebephrenia’ has highlighted a group of patients characterised by an early onset of illness, formal thought disorder, bizarre behaviour and incongruent emotional expression. A proportion ...
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        Hemizygous mutations in L1CAM in two unrelated male probands with childhood onset psychosis 

        James, Anthony; Borsay, Clare (2020-06)
        Objective :To identify genes underlying childhood onset psychosis. Methods :Patients with onset of psychosis at age 13 or younger were identified from clinics across England, and they and their parents were exome sequenced ...

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