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        Anticipatory Pleasure in Current Psychosis: Cognitive and Emotional Correlates 

        Rosebrock, Laina; Waite, Felicity; Diamond, Rowan; Collett, Nicola; Bold, Emily; Chadwick, Eleanor; Teale, Ashley-Louise (2020-12)
        Anticipation of pleasure – a key aspect of hedonic experience - is a motivating factor for engaging in activities. Low levels of anticipatory pleasure and activity are found in individuals with psychosis. Cognitive factors ...
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        Antipsychotic medication versus psychological intervention versus a combination of both in adolescents with first-episode psychosis (MAPS): a multicentre, three-arm, randomised controlled pilot and feasibility study 

        Johns, Louise; Freeman, Daniel; Broome, Matthew R.; James, Anthony (2020-07)
        Background Evidence for the effectiveness of treatments in early-onset psychosis is sparse. Current guidance for the treatment of early-onset psychosis is mostly extrapolated from trials in adult populations. The UK ...
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        Are benzodiazepines effective in treating catatonia? 

        Carthy, Elliott (2020-12)
        Establishing an evidence base for the clinical management of catatonia is made difficult by the heterogeneous nature of the condition and the limited understanding of its pathophysiology. Benzodiazepines are a mainstay of ...
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        Association of Schizophrenia Spectrum Disorders and Violence Perpetration in Adults and Adolescents From 15 Countries A Systematic Review and Meta-analysis 

        Geddes, John R; Fazel, Seena; Whiting, Daniel; Gulati, Gautam (2021-12)
        Violence perpetration outcomes in individuals with schizophrenia spectrum disorders contribute to morbidity and mortality at a population level, disrupt care, and lead to stigma. Objective : To conduct a systematic ...
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        Attitudes to physical healthcare in severe mental illness; a patient and mental health clinician qualitative interview study 

        De Cassan, Simone; Lennox, Belinda (2020-11)
        People with severe mental illness experience physical health significantly worse than the general population. Physical health monitoring is shared between primary care and secondary mental healthcare services, though there ...
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        Autoimmune psychosis: an international consensus on an approach to the diagnosis and management of psychosis of suspected autoimmune origin 

        Lennox, Belinda (2019-10)
        There is increasing recognition in the neurological and psychiatric literature of patients with so-called isolated psychotic presentations (ie, with no, or minimal, neurological features) who have tested positive for ...
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        Automated psychological therapy using virtual reality (VR) for patients with persecutory delusions: study protocol for a single-blind parallel-group randomised controlled trial (THRIVE) 

        Freeman, Daniel; Lister, Rachel; Waite, Felicity (2019-01)
        Persecutory delusions are a major psychiatric problem and are associated with a wide range of adverse outcomes. Our theoretical model views these delusions as unfounded threat beliefs which persist due to defence behaviours ...
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        Automated virtual reality (VR) cognitive therapy for patients with psychosis: study protocol for a single-blind parallel group randomised controlled trial (gameChange). 

        Freeman, Daniel; Lambe, Sinead; Rovira, Aitor; Goodsell, Andrew; Rosebrock, Laina; Geddes, John R; Clark, David M; Waite, Felicity (2019-08)
        Introduction Many patients with psychosis experience everyday social situations as anxiety-provoking. The fears can arise, for example, from paranoia, hallucinations, social anxiety or negative-self beliefs. The fears lead ...
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        Brain glutamate concentration in men with early psychosis: a magnetic resonance spectroscopy case–control study at 7 T 

        Godlewska, Beata R; Lennox, Belinda; Cowen, Philip J (2021-06)
        Abnormalities in glutamate neurotransmission are linked to psychotic symptoms and cognitive dysfunction in schizophrenia. magnetic resonance spectroscopy (MRS) provides an acceptable means of measuring glutamate in the ...
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        Clinicians’ views of treatment types for first episode psychosis delivered in a randomised controlled trial (MAPS) 

        Bird, Jessica C. (2020-07)
        Background Clinicians’ treatment beliefs could affect the feasibility of delivering different treatments in a randomised controlled trial (RCT). In MAPS (Managing Adolescent first Episode Psychosis: a feasibility Study), ...
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        Clozapine-induced pericarditis: an ethical dilemma 

        Johal, Harleen Kaur; Barrera, Alvaro (2019-06)
        Clozapine is an atypical antipsychotic used most frequently in the management of treatment-resistant schizophrenia, where severely unwell patients have failed to respond to standard antipsychotic therapy. Clozapine is ...
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        Cognitive appraisals of dissociation in psychosis: a new brief measure 

        Molodynski, Andrew; Ehlers, Anke; Freeman, Daniel (2020-12)
        Background: Catastrophic cognitive appraisals, similar to those in anxiety disorders, are implicated in depersonalisation, a form of dissociation. No scales exist to measure appraisals of dissociative experiences. ...
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        Cognitive Behavioural Therapy for Nightmares for Patients with Persecutory Delusions (Nites): An Assessor-Blind, Pilot Randomized Controlled Trial 

        Sheaves, Bryony; Waite, Felicity; Harrison, Paul J; Freeman, Daniel (2019-05)
        Objective:Nightmares are relatively common in patients experiencing psychosis but rarely assessed or treated. Nightmares may maintain persecutory delusions by portraying fears in sensory-rich detail. We tested the potential ...
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        The comments of voices on the appearance of patients with psychosis: ‘the voices tell me that I am ugly’ 

        Waite, Felicity; Diamond, Rowan; Collett, Nicola; Teale, Ashley-Louise; Bird, Jessica C.; Cernis, Emma; Isham, Louise; Freeman, Daniel (2019-09)
        Background:There are high rates of obesity and low self-esteem in patients with psychosis. The occurrence of negative voice content directly about appearance is therefore plausible. Derogatory comments about appearance are ...
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        Comparative effects of 18 antipsychotics on metabolic function in schizophrenia, predictors of metabolic dysregulation, and association with psychopathology: a systematic review and network meta-analysis 

        Cipriani, Andrea (2019-10)
        Background: Antipsychotic-treatment is associated with metabolic disturbance. However, the relative degree to which metabolic alterations occur in treatment with different antipsychotics remains unclear. Furthermore, ...
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        A compassionate imagery intervention for patients with persecutory delusions 

        Forkert, Ava; Freeman, Daniel; Waite, Felicity (2021-06)
        Negative beliefs about the self, including low self-compassion, have been identified as a putative causal factor in the occurrence of paranoia. Therefore, improving self-compassion may be one route to reduce paranoia. Aims: To ...
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        Cost and quality-of-life impacts of community treatment orders (CTOs) for patients with psychosis: economic evaluation of the OCTET trial 

        Burns, Tom; Simon, Judit; Yeeles, Ksenija (2020-07)
        Purpose:Current RCT and meta-analyses have not found any effect of community treatment orders (CTOs) on hospital or social outcomes. Assumed positive impacts of CTOs on quality-of-life outcomes and reduced hospital costs ...
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        Critical Developmental Windows of Voltage-Gated Cation Channel Expression in Psychiatric Disorders 

        Al-Juffali, Noura (2021-09)
        The molecular underpinnings of psychiatric disorders remain elusive despite there being a paramount need to establish druggable targets for their treatment. Genome-wide association studies (GWASs) have identified numerous ...
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        Developing an automated VR cognitive treatment for psychosis: gameChange VR therapy 

        Lambe, Sinead; Lister, Rachel; Rosebrock, Laina; Rovira, Aitor; Clark, David M; Freeman, Daniel; Waite, Felicity (2020-04)
        The automated delivery of psychological treatment using virtual reality (VR) has the potential to revolutionise patient access to evidence-based care. VR creates immersive, interactive computer simulations, which elicit ...
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        Development of the Ketamine Side Effect Tool 

        McShane, Rupert (2020-04)
        Background: Currently, no specific, systematic assessment tool for the monitoring and reporting of ketamine-related side effects exists. Our aim was to develop a comprehensive Ketamine Side Effect Tool (KSET) to capture ...

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