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Now showing items 267-286 of 1185
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The development and testing of a novel Cognitive Behavioural Therapy (CBT)-based intervention to support medicines-related consultations for healthcare professionals
(2021-04)Introduction The cost to healthcare of wasted medicines has been estimated at around £300million per annum (1). In response to this figure and efforts to increase medicines management performance across pharmacy and patient ... -
Development and validation of a meta-learner for combining statistical and machine learning prediction models in individuals with depression
(2022-05)The debate of whether machine learning models offer advantages over standard statistical methods when making predictions is ongoing. We discuss the use of a meta-learner model combining both approaches as an alternative. ... -
Development and Validation of a Novel Dementia Risk Score in the UK Biobank Cohort
(2021-03)INTRODUCTION: Current prognostic models of dementia have had limited success in consistently identifying at-risk individuals. We aimed to develop and validate a novel dementia risk score (DRS) using the UK Biobank cohort. ... -
Development and validation of a prediction model for the probability of responding to placebo in antidepressant trials: a pooled analysis of individual patient data
(2019-02)Background: Identifying potential placebo responders among apparent drug responders is critical to dissect drug-specific and nonspecific effects in depression. Objective: This project aimed to develop and test a prediction ... -
Development of a core outcome set for lower limb orthopaedic surgical interventions in ambulant children and young people with cerebral palsy: a study protocol
(2020-03)Introduction Musculoskeletal deformities and gait deviations are common features in ambulatory cerebral palsy (CP). Deformity correction through lower limb orthopaedic surgery is the standard form of care aimed at improving ... -
Development of A Guideline for Reporting Mediation Analyses (AGReMA)
(2020-02)There are a growing number of studies using mediation analysis to understand the mechanisms of health interventions and exposures. Recent work has shown that the reporting of these studies is heterogenous and incomplete. ... -
Development of an app for lung cancer survivors (iEXHALE) to increase exercise activity and improve symptoms of fatigue, breathlessness and depression
(2019-11)Objective Exercise‐based self‐management interventions are recommended for lung cancer survivors and can provide physical, psychosocial and emotional relief. Mobile health technologies can encourage self‐management; ... -
Development of directed global inhibition, competitive inhibition and behavioural inhibition during the transition between infancy and toddlerhood
(2021-04)Abstract Inhibitory control (IC) is a core executive function integral to self-regulation and cognitive control, yet is itself multi-componential. Directed global inhibition entails stopping an action on demand. Competitive ... -
The Development of Guidance for Responding to Disclosure of Non‐recent Child Sexual Abuse within a Large Provider of Health Services for Adults and Children
(2021-01)In a large community health organisation, following high-proile cases of non-recent(historical) child sexual abuse, there was an increase in such disclosures and in uncertainties voiced by clinicians, both medical and ... -
The development of supported mental health accommodation and community psychiatric nursing in Oxfordshire
(2022-11)Overcrowding in British mental hospitals was a major service and political concern when the NHS was introduced in 1948. From 1959, a number of projects were initiated locally in Oxfordshire, based from Littlemore Hospital ... -
Development of the Ketamine Side Effect Tool
(2020-04)Background: Currently, no specific, systematic assessment tool for the monitoring and reporting of ketamine-related side effects exists. Our aim was to develop a comprehensive Ketamine Side Effect Tool (KSET) to capture ... -
Déjà-vu? Neural and behavioural effects of the 5-HT 4 receptor agonist, prucalopride, in a hippocampal-dependent memory task
(2021-10)Cognitive deficits commonly accompany psychiatric disorders but are often underrecognised, and difficult to treat. The 5-HT4 receptor is a promising potential treatment target for cognitive impairment because in animal ... -
Diagnosis Across the Spectrum of Progressive Supranuclear Palsy and Corticobasal Syndrome
(2019-12)IMPORTANCE: Atypical parkinsonian syndromes (APS), including progressive supranuclear palsy (PSP), corticobasal syndrome (CBS), and multiple system atrophy (MSA), may be difficult to distinguish in early stages and are ... -
Diagnostic accuracy and clinical impact of natriuretic peptide screening for the detection of heart failure in the community: a protocol for systematic review and meta-analysis [version 2; peer review: awaiting peer review]
(2019-12)Introduction: Patients diagnosed with heart failure in primary care have a better prognosis than those diagnosed in hospital. However, most cases are missed in the community. Recent attention has focussed on the potential ... -
The different influence of high levels of physical activity on the incidence of knee OA in overweight and obese men and women-a gender specific analysis
(2019-10)Objective To investigate the influence of physical activity on incidence of knee osteoarthritis (OA) in overweight and obese men and women. Design Data were extracted from the Osteoarthritis Initiative cohort on 1,667 ... -
Different Types and Acceptability of Psychotherapies for Acute Anxiety Disorders in Children and Adolescents: A Network Meta-analysis
(2018-10)Anxiety disorders are common in children and adolescents, and uncertainty remains regarding the optimal strategy of psychotherapies in this population. OBJECTIVE: To compare and rank the different types of psychotherapies ... -
Differential effects of poor recall and memory disjointedness on trauma symptoms
(2018)Clinical theories of PTSD suggest that trauma memories are disorganised. The present study examined how trauma film exposure affects two aspects of memory disorganisation, poor memory recall and memory disjointedness, and ... -
Difficult conversations? Engaging patients in reducing waste in health care
(2016)Purpose – Reducing waste in health care can result in savings that could be used to meet the projected shortfall in NHS funding or to meet the care needs of vulnerable groups. Patients and their families can contribute ... -
Digital Cognitive Behavioral Therapy for Insomnia for Adolescents With Mental Health Problems: Feasibility Open Trial
(2020-03)Background: Insomnia in adolescents is common, persistent, and associated with poor mental health including anxiety and depression. Insomnia in adolescents attending child mental health services is seldom directly treated, ... -
Digital health innovation to support sensitive enquiry about female genital mutilation
(2021-05)Health professionals working in community settings are increasingly using mobile technologies to access information and support clients. A Mary Seacole Leadership Award enabled the production of an app, ‘Let's talk FGM’ ...