Browsing by Title
Now showing items 160-179 of 591
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The effect of a genetic variant at the schizophrenia associated AS3MT/BORCS7 locus on striatal dopamine function: A PET imaging study
(2019)One of the most statistically significant loci to result from large-scale GWAS of schizophrenia is 10q24.32. However, it is still unclear how this locus is involved in the pathoaetiology of schizophrenia. The hypothesis ... -
The effect of a youth mental health service model on access to secondary mental healthcare for young people aged 14–25 years
(2018-09)Aims and method The Norfolk Youth Service was created in 2012 in response to calls to redesign mental health services to better meet the needs of young people. The new service model transcends traditional boundaries by ... -
Effect of acute citalopram on self-referential emotional processing and social cognition in healthy volunteers
(2020-10)Background Depression is characterised by negative views of the self. Antidepressant treatment may remediate negative self-schema through increasing processing of positive information about the self. Changes in affective ... -
Effect of Assertive Community Treatment for Patients with Substance Use Disorder: A Systematic Review
(2019-01-30)Substance use disorders (SUD) are an important health issue internationally. Traditional outpatient programmes often do not adequately address the substantial medical and social needs and in addition many patients ... -
Effect of glucose and sucrose on cognition in healthy humans: a systematic review and meta-analysis of interventional studies
(2020-06)Context: Evidence suggests that plasma glucose levels may influence cognitive performance, but this has not been systematically reviewed and quantified. Objective: The aim of this review was to investigate the potential ... -
Effect of point of care blood testing on physical health check completion in mental health services: mixed-methods evaluation
(2020-10)Physical health outcomes in severe mental illness are worse than in the general population. Routine physical health check completion in this group is poor. Aims To quantitatively and qualitatively evaluate the impact of ... -
Effect of Prefrontal Cortex Stimulation on Regulation of Amygdala Response to Threat in Individuals With Trait Anxiety A Randomized Clinical Trial
(2019-01)Importance Transcranial direct current stimulation (tDCS) of the dorsolateral prefrontal cortex (DLPFC) is under clinical investigation as a treatment for major depressive disorder. However, the mechanisms of action are ... -
The effect of prenatal education classes on the birth expectations of Spanish women
(2018-05)Maternity care has focused on lowering maternal and neonatal morbidity, though women's beliefs and expectations of care have been set aside. Women face childbirth with preconceived expectations, some of which could be ... -
The effect of the DISC1 Ser704Cys polymorphism on striatal dopamine synthesis capacity: an [18F]-DOPA PET study
(2018-06)Whilst the role of the Disrupted-in-Schizophrenia 1 (DISC1) gene in the aetiology of major mental illnesses is debated, the characterisation of its function lends it credibility as a candidate. A key aspect of this functional ... -
Effect of the NMDA receptor partial agonist, d-cycloserine, on emotional processing and autobiographical memory
(2020-04)Background: Studies suggest that d-cycloserine (DCS) may have antidepressant potential through its interaction with the glycine site of the N-Methyl-D-aspartate receptor (NMDAR); however clinical evidence of DCS’s efficacy ... -
Effective psychological treatment for PTSD changes the dynamics of specific large-‐scale brain networks
(2020-01)Very little is known about the role of effective cognitive therapy in reversing imbalances in brain activity after trauma. We hypothesised that exaggerated threat perception characteristic of p ... -
Effectiveness and Acceptability of Cognitive Behavior Therapy Delivery Formats in Adults With Depression A Network Meta-analysis
(2019-04)Importance Cognitive behavior therapy (CBT) has been shown to be effective in the treatment of acute depression. However, whether CBT can be effectively delivered in individual, group, telephone-administered, guided ... -
Effectiveness of cognitive–behavioural therapy: a protocol for an overview of systematic reviews and meta-analyses
(2018-12)Introduction Cognitive–behavioural therapy (CBT) is a psychological therapy that has been used to improve patient well-being across multiple mental and physical health problems. Its effectiveness has been examined in ... -
The effectiveness of interventions aimed at improving wellbeing and resilience to stress in first responders: A systematic review
(2020-07)First responders are routinely exposed to traumatic critical incidents, placing them at higher risk for developing stress-related psychopathology and associated health problems than the general population. Interventions ... -
Effectiveness of maintenance therapy of lithium vs other mood stabilizers in monotherapy and in combinations: A systematic review of evidence from observational studies
(2018-02)Objectives: For the first time to present a systematic review of observational studies on the efficiency of lithium monotherapy in comparison with other maintenance mood stabilizers in monotherapy and in combination. Methods: ... -
The effectiveness of the Older prisoner Health and Social Care Assessment and Plan (OHSCAP): a randomised controlled trial
(2017-12)Older prisoners (aged ≥ 50 years) are the fastest growing subgroup in English prisons, and have complex health and social care needs. In a previous study, prisoners and prison and health-care staff worked together to ... -
Effectiveness of Vitamin D Supplementation in the Management of Multiple Sclerosis: A Systematic Review
(2019-03)The main objective was to examine the extent of effect vitamin D in Multiple Sclerosis (MS) on pathology and symptoms. A literature search was performed in November 2018 (CRD42018103615). Eligibility criteria: randomised ... -
Effects of a mindfulness-based stress reduction group programme on family carers
(2019-11)Background Mindfulness-based stress reduction (MBSR) is an evidence-based intervention that teaches participants skills in reducing stress and managing challenging emotions in a group setting. Mindfulness-based therapies ... -
The effects of an aerobic training intervention on cognition, grey matter volumes and white matter microstructure
(2020-05)While there is strong evidence from observational studies that physical activity is associated with reduced risk of cognitive decline and dementia, the extent to which aerobic training interventions impact on cognitive ... -
The effects of digital cognitive behavioral therapy for insomnia on cognitive function: a randomized controlled trial
(2020-03)We sought to examine the impact of digital cognitive behavioral therapy (dCBT) for insomnia on both self-reported cognitive impairment and objective cognitive performance. MethodsT: he Defining the Impact of Sleep improvement ...
