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Now showing items 1087-1106 of 1185
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Ultra-processed foods and binge eating: A retrospective observational study
(2021-04)There is increasing evidence of the impact of ultra-processed foods on multiple metabolic and neurobiological pathways, including those involved in eating behaviors, both in animals and in humans. In this study we aimed ... -
Ultradian hydrocortisone replacement alters neuronal processing, emotional ambiguity, affect and fatigue in adrenal insufficiency: The PULSES trial
(2023-10)Background: Primary adrenal insufficiency (PAI) mortality and morbidity remain unacceptably high, possibly arising as glucocorticoid replacement does not replicate natural physiology. A pulsatile subcutaneous pump can ... -
Unbalanced risk-benefit analysis of ADHD drugs – Authors' reply
(2018)Standardised mean differences can be difficult to translate into clinical practice. As reported in the Cochrane handbook, the mean difference (or more correctly, difference in means) measures the absolute difference between ... -
Understanding agoraphobic avoidance: the development of the Oxford Cognitions and Defences Questionnaire (O-CDQ)
(2022-02)Many patients with mental health disorders become increasingly isolated at home due to anxiety about going outside. A cognitive perspective on this difficulty is that threat cognitions lead to the safety-seeking behavioural ... -
Understanding and working with suicide risk
(2015-07)Key learning points: Understanding risk factors associated with suicide; Considering a framework for understanding suicide; How to assess and manage suicide risk -
Understanding antibiotic-seeking behaviour: A qualitative case study of mothers of children aged 5 and under
(2022-07)Antibiotics savelives and have been effectively and reliably used for decades to treat infections and improve health outcomes. This trust in antibiotics has contributed to over prescribing and the emergence of antimicrobial ... -
Understanding clinical decision-making in mesothelioma care: a mixed methods study
(2022-07)Malignant pleural mesothelioma is a rare, incurable cancer arising from previous asbestos exposure; patients have a poor prognosis, with a median survival rate of 8–14 months. Variation in mesothelioma clinical decision-making ... -
Understanding health anxiety in the COVID-19 pandemic
(2021-11)The COVID-19 pandemic continues to be one of the greatest public health challenges faced by the UK. Reported rates of psychiatric difficulties have increased and the mechanisms by which the pandemic has affected mental ... -
Understanding young peoples’ and family members’ views of treatment for first episode psychosis in a randomised controlled trial (MAPS)
(2020-07)Background;There is limited evidence to inform treatment decision-making in adolescents experiencing first episode psychosis (FEP). In the MAPS trial (Managing Adolescent first Episode Psychosis: a feasibility Study), ... -
Understanding, treating, and renaming grandiosedelusions: A qualitative study
(2019-11)Background.Grandiose delusions are arguably the most neglected psychotic experience in research. Objectives.We aimed to discover from patients: whether grandiose delusions have harmful consequences; the psychological ... -
Unimodal and bimodal access to sensory working memories by auditory and visual impulses
(2019-11)It is unclear to what extent sensory processing areas are involved in the maintenance of sensory information in working memory (WM). Previous studies have thus far relied on finding neural activity in the corresponding ... -
Unmet Rehabilitation Needs after Traumatic Brain Injury across Europe: Results from the CENTER-TBI Study
(2021-03)This study aims to assess rehabilitation needs and provision of rehabilitation services for individuals with moderate-to-severe disability and investigate factors influencing the probability of receiving rehabilitation ... -
Unraveling Mechanisms of Patient-Specific NRXN1 Mutations in Neuropsychiatric Diseases Using Human Induced Pluripotent Stem Cells
(2020-03)Rare heterozygous deletions in the neurexin 1 (NRXN1) gene robustly increase an individual's risk of developing neurological and psychiatric disorders. However, the molecular bases by which different mutations result in ... -
Unravelling the complex interactions between self-awareness, cognitive change, and mood at 6-months post-stroke using the Y-shaped model
(2022-02)We investigated the relationships between cognitive change following stroke, awareness of cognitive impairments, and mood to further understanding of change processes influencing psychological outcomes post-stroke ... -
Untreatable or unable to treat? Creating more effective and accessible treatment for long-standing and severe eating disorders
(2023-02)The evidence base for the treatment of severe eating disorders is limited. In addition to improving access to early intervention, there is a need to develop more effective treatments for complex presentations of eating ... -
Update to the effectiveness and cost-effectiveness of a mindfulness training programme in schools compared with normal school provision (MYRIAD): study protocol for a randomised controlled trial
(2021-04)Background MYRIAD (My Resilience in Adolescence) is a superiority, parallel group, cluster randomised controlled trial designed to examine the effectiveness and cost-effectiveness of a mindfulness training (MT) programme, ... -
Usability of Health Information Websites Designed for Adolescents: Systematic Review, Neurodevelopmental Model, and Design Brief
(2019-04)Background: Adolescence is a unique developmental period characterized by biological, social, and cognitive changes, as well as an interest in managing one’s own health care. Many adolescents use the internet to seek health ... -
A usability study to test the effectiveness, efficiency and simplicity of a newly developed Internet-based Exercise-focused Health App for Lung cancer survivors (iEXHALE): Protocol paper
(2019-10)The Internet-based Exercise-focused Health App for Lung cancer survivors (iEXHALE) is a mobile web app being developed to provide lung cancer survivors with an algorithm-based, tailor-made, self-management programme to ... -
Use and risk of side effects of antiresorptive medication in people with intellectual disabilities [version 1; peer review: awaiting peer review]
(2022-12)Background: Recent studies show that adults with intellectual disabilities (ID) have high incidence of major osteoporotic fracture, especially hip fracture. In those ≥ 50 years, women and men with ID have an approximately ... -
The use of Fox’s glacier mints to treat ibs-type symptoms in patients with anorexia nervosa in an adult specialist eating disorder unit
(2021-03)Background: Patients with Anorexia Nervosa (AN) often experience Irritable Bowel Syndrome (IBS) type symptoms, including bloating, abdominal pain and acid reflux.(1) Pepper mint oil is used to treat IBS symptoms, due to ...