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Now showing items 1067-1086 of 1185
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Time to focus more on promoting mental health than treating mental illness
(2018-03)Mental health problems are a major contributor to overall burden of disease worldwide. In UK, it represents up to 23% of the total burden of disease - the largest single cause of disability. To build a healthier, more ... -
The times they are a-changin’
(2018-07)Editorial: "The first issue of Evidence-Based Mental Health (EBMH) is celebrating the 20th anniversary. Readers were welcomed to EBMH in 1998, which was designed to assist ‘mental health clinicians stay up to date with the ... -
Toward a neurobiology of internal selective attention
(2021-07)A recent study in non-human primates (NHPs) by Panichello and Buschman brings the investigation of selective attention within visual working memory to the systems and cellular neuroscience levels. We reflect on this ... -
Towards precision in the diagnostic profiling of patients: leveraging symptom dynamics in the assessment of major depressive disorder
(2023-08)Major depressive disorder (MDD) is a heterogeneous mental disorder. International guidelines present overall symptom severity as the key dimension for clinical characterisation. However, additional layers of individual ... -
Trace amine-associated receptor 1 (TAAR1) agonists for psychosis: protocol for a living systematic review and meta-analysis of human and non-human studies.
(2023-08)Background: There is an urgent need to develop more effective and safer antipsychotics beyond dopamine 2 receptor antagonists. An emerging and promising approach is TAAR1 agonism. Therefore, we will conduct a living ... -
Trainee Leadership Board: learning about NHS leadership
(2018-03-27)Introduction: The development of a new generation of clinical leaders in the NHS has been increasingly endorsed by most recent literature in medical leadership and management. Despite providing academic rationale and ... -
Training and service provision for people with intellectual disability and mental illness: the views of psychiatrists
(2018-10-24)Objectives: The objectives of this mixed methods study are to 1) investigate the knowledge and skills of mainstream psychiatrists in managing patients with Intellectual Disability (ID) and comorbid mental health disorders, ... -
Transient spectral events in resting state MEG predict individual task responses
(2020-07)Even in response to simple tasks such as hand movement, human brain activity shows remarkable inter-subject variability. Recently, it has been shown that individual spatial variability in fMRI task responses can be ... -
Translating the promise of 5HT4 receptor agonists for the treatment of depression
(2020-02)Animal experimental studies suggest that 5-HT4 receptor activation holds promise as a novel target for the treatment of depression and cognitive impairment. 5-HT4 receptors are postsynaptic receptors that are located in ... -
Translating the Strengthening and Stretching for Rheumatoid Arthritis of the Hand Programme from clinical trial to clinical practice: An effectiveness–implementation study
(2020-09)Introduction The Strengthening and Stretching for Rheumatoid Arthritis of the Hand programme is a hand exercise programme for people with rheumatoid arthritis. It was clinically effective when delivered during a clinical ... -
Trauma, mental health and the COVID-19 crisis: are we really all in it together?
(2021-02)As the world adapts to varying levels of social lockdown – and the lifting of restrictions – due to the COVID-19 pandemic, evidence is mounting that quarantine and other social restrictions negatively affect the mental ... -
Treating sleep problems in young people at ultra-high-risk of psychosis: study protocol for a single-blind parallel group randomised controlled feasibility trial (SleepWell).
(2020-11)Background Effective interventions, targeting key contributory causal factors, are needed to prevent the emergence of severe mental health problems in young people. Insomnia is a common clinical issue that is problematic ... -
Treating Social Anxiety Disorder Remotely with Cognitive Therapy
(2020-07)Remote delivery of evidence-based psychological therapies via video conference has become particularly relevant following the COVID-19 pandemic, and is likely to be an on-going method of treatment delivery post-COVID. ... -
Treatment for depression comorbid with dementia
(2019-11)Depression is a common comorbidity in dementia. Randomised controlled studies of antidepressants do not show a significant improvement in depressive symptoms in patients with comorbid dementia and are known to lead to an ... -
Treatment of Inappropriate Sexual Behavior in Dementia
(2016-08)Inappropriate sexual behavior (ISB) is a relatively common and potentially disruptive form of behavior in people with dementia. It can cause considerable distress and put placements and people at risk. Yet it is poorly ... -
Treatment Outcomes With Licensed and Unlicensed Stimulant Doses for Adults With Attention-Deficit/Hyperactivity Disorder A Systematic Review and Meta-Analysis
(2023-10)Importance Stimulants (methylphenidate and amphetamines) are often prescribed at unlicensed doses for adults with attention-deficit/hyperactivity disorder (ADHD). Whether dose escalation beyond US Food and Drug Administration ... -
Treatment-resistant depression: therapeutic options when first-line treatments fail
(2021-12)The Cochrane review by Davies et al aimed to address the lack of clarity on the risks and benefits of switching and augmentation strategies in the pharmacological treatment of treatment-resistant depression in adults who ... -
Trends in antidepressant prescriptions in children and young people in England, 1998–2017: protocol of a cohort study using linked primary care and secondary care datasets
(2019-06)Introduction: Increasing numbers of children and young people (CYP) are receiving prescriptions for antidepressants. This is the protocol of a study aiming to describe the trends and variation in antidepressant prescriptions ... -
The True Colours Remote Symptom Monitoring System: A Decade of Evolution
(2020-01)The True Colours remote mood monitoring system was developed over a decade ago by researchers, psychiatrists, and software engineers at the University of Oxford to allow patients to report on a range of symptoms via text ... -
Typologies for Restructuring Relationships in Cancer Survivorship
(2017-07)Background: Cancer survivors with good social support are generally more motivated to undertake self-management behaviors and make lifestyle changes. However, the impact of changes in social support over time, from ...