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Incidence of Parkinson’s disease, dementia, cerebrovascular disease and stroke in bipolar disorder compared to other psychiatric disorders: An electronic health records network study of 66 million people
(2020-10)
Bipolar disorder has been associated with an increased risk for neurodegenerative diseases, but uncertainties remain. The risk relative to other psychiatric disorders is not established.
Methods
We used a federated ...
Effectiveness of maintenance therapy of lithium vs other mood stabilizers in monotherapy and in combinations: A systematic review of evidence from observational studies
(2018-02)
Objectives: For the first time to present a systematic review of observational studies on the efficiency of lithium
monotherapy in comparison with other maintenance mood stabilizers in monotherapy and in combination.
Methods: ...
Modelling suicide in bipolar disorders: Limitations and opportunities
(2018-07)
Commentary on: Malhi GS, Outhred T, Das P et al. Modeling suicide in bipolar disorders. Bipolar Disord. 2018. In their paper in this issue, Malhi et al highlight a key clinical area; whilst suicide rates are increased in ...
A signature-based machine learning model for distinguishing bipolar disorder and borderline personality disorder
(2018)
Mobile technologies offer new opportunities for prospective, high resolution monitoring of long-term health
conditions. The opportunities seem of particular promise in psychiatry where diagnoses often rely on retrospective
and ...
Experiences of remote mood and activity monitoring in bipolar disorder: a qualitative study
(2017-01)
Mobile technology enables high frequency mood monitoring and automated passive collection of date(e.g.actigraphy) from patients more efficiently and less intrusively than has previously been possible. Such techniques are ...
Comparative economic evaluation of quetiapine plus lamotrigine combination vs quetiapine monotherapy (and folic acid vs placebo) in patients with bipolar depression (cequel)
(2018-12)
Although not licensed for acute bipolar depression, lamotrigine has evidence for efficacy in trials and
its use is recommended in guidelines. So far there had been no prospective health economic evaluation of its
use. ...
Actigraphic patterns, impulsivity and moodinstability in bipolar disorder, borderlinepersonality disorder and healthy controls.
(2020-01)
Objectives:To differentiate the relation between the structure and timing of rest-activity patterns and symptoms of impulsivity and mood instability in bipolar disorder (BD), borderline personality disorder(BPD) and healthy ...
Changes in brain Glx in depressed bipolar patients treated with lamotrigine: A proton MRS study
(2019-03)
Background
Lamotrigine is a useful treatment in bipolar depression but requires several weeks of dose titration before its clinical effects can be assessed. Animal experimental studies suggest that lamotrigine lowers ...
Induced pluripotent stem cells in psychiatry: a critical review
(2021-01)
A key challenge in psychiatry research is the development of high-fidelity model systems that can be experimentally manipulated to explore and test pathophysiological mechanisms of illness. In this respect, the emerging ...
Longitudinal cognitive performance in patients with Bipolar Disorder
(2020-01)
Commentary: Neurocognitive impairments are a rather common occurrence in euthymic Bipolar Disorder (BD) patients. Understanding the degree of longitudinal stability of these deficits is vital in the management and treatment ...