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Now showing items 21-30 of 43
Cyclical Cushing's syndrome and the presentation of a Bipolar Affective state
(2019-12)
Affective disorders are relatively frequently observed in patients suffering from endocrine disease. Thus, in Cushing's syndrome, the most common comorbid mental disorder seen is depressive disorder. The rarer cyclical ...
Learning to Detect Bipolar Disorder and Borderline Personality Disorder with Language and Speech in Non-Clinical Interviews
(2020-08)
Bipolar disorder (BD) and borderline personality disorder
(BPD) are both chronic psychiatric disorders. However, their
overlapping symptoms and common comorbidity make it challenging
for the clinicians to distinguish ...
Functional Connectivity between Task-Positive Networks and the Left Precuneus as a Biomarker of Response to Lamotrigine in Bipolar Depression: A Pilot Study
(2021-06)
Treatment of bipolar depression poses a significant clinical challenge. Lamotrigine is one of a few efficacious drugs, however, it needs to be titrated very slowly and response can only be assessed after 10–12 weeks. With ...
Effect of lithium on circadian rhythm in bipolar disorder: A systematic review and meta-analysis
(2021-03)
Circadian rhythm disruption is commonly reported in patients with bipolar disorder. Lithium has been suggested to have effects on the circadian clock, the biological basis of the circadian rhythm. The objective of the ...
The Oxford study of Calcium channel Antagonism, Cognition, Mood instability and Sleep (OxCaMS): study protocol for a randomised controlled, experimental medicine study
(2019-02)
Background:
The discovery that voltage-gated calcium channel genes such as CACNA1C are part of the aetiology of psychiatric disorders has rekindled interest in the therapeutic potential of L-type calcium channel (LTCC) ...
The costs of bipolar disorder in the United Kingdom
(2021-09)
Objectives: To estimate the individual cost and population-level economic burden of Bipolar Disorder (BD), and explore the impact of clinical and sociodemographic factors on costs in the United Kingdom.
Methods: Annual ...
Characterising the severity of treatment resistance in unipolar and bipolar depression
(2021-10)
Treatment-resistant depression (TRD) is classically defined according to the number of suboptimal antidepressant responses experienced, but multidimensional assessments of TRD are emerging and may confer some advantages. ...
Study protocol for a randomised placebo-controlled trial of pramipexole in addition to mood stabilisers for patients with treatment resistant bipolar depression (the PAX-BD study)
(2021-07)
Treatment Resistant Bipolar Depression (TRBD) is a major contributor to the burden of disease associated with Bipolar Disorder (BD). Treatment options for people experiencing bipolar depression are limited to three ...
Behavioural sleep and circadian rhythm interventions in bipolar disorder: a systematic review of randomised controlled trials
(2021-07)
Sleep and circadian rhythm disruptions are prominent symptoms of bipolar
disorder (BD) and potential targets for adjunctive behavioural intervention. The aim of this
systematic review was to appraise evidence from ...
Imagery-Based Cognitive Therapy for Bipolar Disorder and Mood Instability
(Guilford Press, 2019)
People with bipolar disorder are particularly vulnerable to anxiety and intrusive mental imagery, which can contribute to mood swings and a heightened risk for relapse. This book presents a novel brief treatment that focuses ...