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Now showing items 31-40 of 43
Onset and recurrence of psychiatric disorders associated with anti-hypertensive drug classes
(2021-05)
The major anti-hypertensive (AHT) drug classes have been associated with differential risks of psychiatric disorders. However, existing data are limited largely to depression, and confounding variables have not always been ...
Melatonin In Acute Mania Investigation (MIAMI‐UK). A randomised controlled trial of add‐on melatonin in bipolar disorder
(2020-05)
Objectives
Current options for treating emergent episodes of hypomania and mania in bipolar disorder are limited. Our objective was to compare the effectiveness and safety of add‐on melatonin in hypomania or mania over ...
Plasma glutathione suggests oxidative stress is equally present in early- and late- onset bipolar disorder
(2018-03)
We previously demonstrated oxidative stress in bipolar patients and a
relationship between the age of illness onset and total glutathione, a principal antioxi-
dant. In this study, we sought to replicate these findings ...
Appraisal of patient-level health economic models of severe mental illness: systematic review
(2021-08)
Healthcare decision makers require accurate long-term economic models to evaluate the cost-effectiveness of new mental health interventions.
Aims
To assess the suitability of current patient-level economic models to ...
Effectiveness of medical treatment for bipolar disorder regarding suicide, self-harm and psychiatric hospital admission: between- and within-individual study on Danish national data
(2022-04)
Mood stabilisers are the main treatment for bipolar disorder. However, it is uncertain which drugs have the best outcomes.
Aims
To investigate whether rates of suicide, self-harm and psychiatric hospital admission in ...
Sleep deprivation as a treatment for major depressive episodes: A systematic review and meta-analysis
(2022-05)
Sleep deprivation, alone or in combination with pharmacological treatment and as part of a chronotherapy package, is of potential use for people with major depressive episodes, however the evidence base is still conflicting. ...
Psychosocial markers of age at onset in bipolar disorder: a machine learning approach
(2022-07)
Bipolar disorder is a chronic and severe mental health disorder. Early stratification of individuals into subgroups based on age at onset (AAO) has the potential to inform diagnosis and early intervention. Yet, the ...
An Overview of Sleep and Circadian Rhythms in Bipolar Disorder
(2022-03)
Since the conception of bipolar disorder (BD) as a psychiatric condition, sleep and circadian rhythm disruptions have been cardinal symptoms of the disorder. Current nosologies recognise this and such disruptions form part ...
Characterizing Affective Variability in Bipolar Disorder and Borderline Personality Disorder, and the Effects of Lithium, Using a Generative Model of Affect
(2022-02)
The affective variability of Bipolar Disorder (BD) is thought to qualitatively differ from that of Borderline Personality Disorder (BPD), with changes in affect persisting for longer in BD. However, quantitative studies ...
The IBER study: a feasibility randomised controlled trial of Imagery Based Emotion Regulation for the treatment of anxiety in bipolar disorder
(2022-11)
Background: Intrusive mental imagery is associated with anxiety and mood instability within bipolar
disorder and therefore represents a novel treatment target. Imagery Based Emotion Regulation (IBER) is a
brief structured ...