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Now showing items 899-918 of 1185
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The relationship between striatal dopamine and anterior cingulate glutamate in first episode psychosis changes with antipsychotic treatment
(2023-05)The neuromodulator dopamine and excitatory neurotransmitter glutamate have both been implicated in the pathogenesis of psychosis, and dopamine antagonists remain the predominant treatment for psychotic disorders. To date ... -
Reliability and validity of the FORUM-P and FORUM-C: two novel instruments for outcome measurement in forensic mental health
(2022-05)We conducted a series of tests on the FORensic oUtcome Measure (FORUM), a novel tool for measuring outcomes in forensic mental health services, which consists of complementary patientreported (FORUM-P) and clinician-reported ... -
Remotely Close during Covid19 Lockdown – exploring Intensive Interaction via Zoom
(2020-09)With the start of the lockdown in response to the coronavirus pandemic it initially seemed that our work would become nigh on impossible. Working in services that provide health and educational support to people with severe ... -
Replacing meat with alternative plant-based products (RE-MAPs): protocol for a randomised controlled trial of a behavioural intervention to reduce meat consumption
(2019-06)Introduction: Reducing meat consumption could contribute towards preventing some chronic conditions and protecting the natural environment. This study will examine the effectiveness of a behavioural intervention to reduce ... -
Replay bursts in humans coincide with activation of the default mode and parietal alpha networks
(2020-12)Replay in humans coincides with activity in specific resting brain networks Clusters of heightened default mode and alpha activity are linked to replay bursts These networks are characterized by highly synchronized ... -
Reporting on suicidal behaviour and COVID-19—need for caution
(2020-11)News reporting on suicidal behaviour can have a considerable influence on suicide and self-harm in the general population.1 This issue is particularly relevant during the COVID-19 pandemic. With a rising number of ... -
Representation and Outcomes of Individuals With Schizophrenia Seen in Everyday Practice Who Are Ineligible for Randomized Clinical Trials
(2022-02)IMPORTANCE Most evidence about efficacy and safety of antipsychotics in schizophrenia spectrum disorders relies on randomized clinical trials (RCTs). However, owing to their strict eligibility criteria, RCTs represent ... -
Reproducibility of dietary intakes of macronutrients, specific food groups, and dietary patterns in 211 050 adults in the UK Biobank study
(2019-09)To detect modest associations of dietary intake with disease risk, observational studies need to be large and control for moderate measurement errors. The reproducibility of dietary intakes of macronutrients, food groups ... -
Research Review: Viewing self-harm images on the internet and social media platforms: systematic review of the impact and associated psychological mechanisms
(2023-03)iewing self-harm and suicide-related images online can precede these behaviours. We reviewed studies of potential impacts and mechanisms associated with viewing self-harm-related images on the internet and social ... -
Residual eating disorder symptoms and clinical features in remitted and recovered eating disorder patients: A systematic review with meta-analysis
(2019-06)Objective: In psychiatry, the presence of residual symptoms after treatment is linked to the definitions of remission and recovery. To identify the presence of residual eating disorder (ED) symptoms and associated non‐ED ... -
Resting state functional connectivity patterns as biomarkers of treatment response to escitalopram in patients with major depressive disorder
(2021-09)With no available response biomarkers, matching an appropriate antidepressant to an individual can be a lengthy process. Improving understanding of processes underlying treatment responsivity in depression is crucial for ... -
Results and Learning from the Healthy Outcomes for People with Eating Disorders (HOPE) New Care Model (Provider Collaborative) pilot: More investment required to address demand and capacity in adult community and inpatient eating disorder services
(2021-06)This article reports on pilot results and lessons learned from the HOPE New Care Model (Provider Collaborative). Pre-pandemic 12 beds were needed per million population. Demand for beds could be reduced by addressing the ... -
A retrospective examination of care pathways in individuals with treatment-resistant depression
(2021-05)Individuals with treatment-resistant depression (TRD) experience a high burden of illness. Current guidelines recommend a stepped care approach for treating depression, but the extent to which best-practice care pathways ... -
Right Lateralized Brain Reserve Offsets Age-Related Deficits in Ignoring Distraction
(2020-09)Age-related deterioration of attention decreases the ability to stay focused on the task at hand due to less efficient selection of relevant information and increased distractibility in the face of irrelevant, but salient ... -
Rischio di mortalità con i farmaci antipsicotici nella popolazione psichiatrica anziana? Una revisione sistematica della letteratura
(2016)Scopo dello studio: In Italia, gli anziani raggiungono quasi un quarto della popolazione generale. In questo sottogruppo, gli antipsicotici sono ampiamente prescritti: nonostante siano autorizzati esclusivamente per ... -
Risk assessment scales to predict risk of hospital treated repeat self-harm: A cost-effectiveness modelling analysis
(2019-04-15)Risk scales are used widely for assessing individuals presenting to Emergency Departments (EDs) following self-harm. There is growing evidence that risk scales have limited clinical utility in identifying episodes at highest ... -
Risk factors for interpersonal violence: an umbrella review of meta-analyses
(2018-07)Background: Interpersonal violence is a leading cause of morbidity and mortality. The strength and population effect of modifiable risk factors for interpersonal violence, and the quality of the research evidence is not ... -
Risk Factors for Mobility Decline in Community-Dwelling Older Adults: A Systematic Literature Review
(2021-08)Mobility is essential to maintaining independence for older adults. This systematic review aimed to summarize evidence about self-reported risk factors for self-reported mobility decline; and to provide an overview of ... -
Risk, demand and capacity in adult specialist eating disorder services in the South of England – before and since Covid-19
(2020-12)Aims and Method: This is a longitudinal cohort study describing the demand and capacity for specialist inpatient treatment of patients with severe eating disorders covering a population of 3.5 million. We compared the ... -
Risks, roles and responsibilities: Evaluating falls in inpatient mental healthcare settings for older people
(2022-02)Background Despite the large number of falls in mental health settings, we know little about what contributes to falls. The main aim of the study is to explore how fall risk, prevention and management is understood and ...