Browsing by Title
Now showing items 293-312 of 1185
-
Disrupted‐in‐schizophrenia 1 functional polymorphisms and D2/D3 receptor availability: A [11C]‐(+)‐PHNO imaging study
(2019-07)The disrupted‐in‐schizophrenia 1 (DISC1) protein has been implicated in a range of biological mechanisms underlying chronic mental disorders such as schizophrenia. Schizophrenia is associated with abnormal striatal dopamine ... -
Disrupting the power balance between doctors and patients in the digital era
(2021-01)The primary way of identifying symptoms of impending disease, and when it is time to seek care, relies heavily on a patient's own perception of how they feel. This reliance on a disease reaching a threshold at which ... -
Dissecting Transient Burst Events
(2020-10)Increasing efforts are being made to understand the role of intermittent, transient, high-power burst events of neural activity. These events have a temporal, spectral, and spatial domain. Here, we argue that considering ... -
Dissociating Spatial Attention from Neglect Dyslexia: a Single Case Study
(2020-06)Word-centred neglect dyslexia is generally thought to be caused by a visuospatial neglect-like attentional deficit which impacts orientation-canonical representations of visual stimuli. However, the relationship between ... -
Dissociation in patients with non-affective psychosis: Prevalence, symptom associations, and maintenance factors
(2021-11)Dissociation is problematic in its own right for patients with psychosis but may also contribute to the occurrence of psychotic experiences. We therefore set out to estimate in a large cohort of patients with psychosis the ... -
Dissociation in relation to other mental health conditions: An exploration using network analysis
(2020-08)Dissociative experiences, traditionally studied in relation to trauma and PTSD, may be important phenomena across many different psychological conditions, including as a contributory causal factor for psychotic experiences. ... -
A Dissociation of the Acute Effects of Bupropion on Positive Emotional Processing and Reward Processing in Healthy Volunteers
(2018-10)Background: Previous research indicates that antidepressants can restore the balance between negative and positive emotional processing early in treatment, indicating a role of this effect in later mood improvement. However, ... -
Do communication interventions affect the quality-of-life of people with dementia and their families? A systematic review
(2023-04)Speech, language and communication difficulties are prevalent in all dementia subtypes and are likely to considerably impact the quality-of-life of people with dementia and their families. Communication interventions ... -
Do environmental risk factors for the development of psychosis distribute differently across dimensionally assessed psychotic experiences?
(2021-04)Psychotic experiences (PE) are associated with poorer functioning, higher distress and the onset of serious mental illness. Environmental exposures (e.g. childhood abuse) are associated with the development of PE. However, ... -
‘Do not attempt cardiopulmonary resuscitation’ (DNACPR)—difficulty in discussions with older medical inpatients and their families: a survey of hospital doctors
(2021-07)Objectives To determine, for doctors looking after older medical inpatients: (1) how difficult they find discussions about ‘do not attempt cardiopulmonary resuscitation’ (DNACPR); (2) whether difficulty is associated with ... -
Do parent factors predict early weight gain in family therapy for anorexia nervosa? Revisiting variables in a community treatment sample
(2020-12)Objective: It is unclear why some children and adolescents respond well to family therapy for anorexia nervosa (AN) and others do not. Previous exploratory studies have suggested that parent variables may be important ... -
Do sagittal spinal curvature and back extensor endurance correlate with gait and balance measures in people with degenerative spinal conditions?
(2022-02)The aim was to investigate the relationship between sagittal spinal curvature and endurance with dynamic balance and gait in people with symptomatic degenerative spinal conditions. Methods: In this cohort study, participants ... -
Do they really care? Specificity of social support issues in hoarding disorder and obsessive-compulsive disorder
(2023-05)Objectives: Unmet interpersonal needs may play a role in excessive emotional attachments to objects for people with hoarding disorder (HD). Previous research indicates that social support (but not attachment difficulties) ... -
Does adjunctive digital CBT for insomnia improve clinical outcomes in an improving access to psychological therapies service?
(2021-09)Insomnia has a bidirectional relationship with broader mental health functioning, including anxiety and depression. Yet, poor sleep has historically been neglected as a specific treatment target in mental health programmes ... -
Does cranberry extract reduce antibiotic use for symptoms of acute uncomplicated urinary tract infections (CUTI)? Protocol for a feasibility study
(2019-12)Consultations in primary care for symptoms of urinary tract infections (UTIs) are common and patients are frequently treated with antibiotics. Given increasing antimicrobial resistance, there has been interest in non-antibiotic ... -
Does raising heart rate prior to a behavioural test enhance learning in cognitive therapy for anxiety? An experimental test for the treatment of fear of heights using virtual reality
(2021-07)A key clinical issue is how to maximise the belief change central to cognitive therapy. Physiological arousal is a key internal cue confirming threat beliefs in anxiety disorders. Deeper extinction of anxiety may occur if ... -
Does repeatedly viewing overweight versus underweight images change perception of and satisfaction with own body size?
(2020-04)Body dissatisfaction is associated with subsequent eating disorders and weight gain. One-off exposure to bodies of different sizes changes perception of others' bodies, and perception of and satisfaction with own body size. ... -
Does the UK medical education provide doctors with sufficient skills and knowledge to manage patients with eating disorders safely?
(2018-06)Background: Eating disorders affect 1%–4% of the population and they are associated with an increased rate of mortality and multimorbidity. Following the avoidable deaths of three people the parliamentary ombudsman called ... -
Dopaminergic modulation of regional cerebral blood flow: An arterial spin labelling study of genetic and pharmacological manipulation of COMT activity
(2021-07)Dopamine has direct and complex vasoactive effects on cerebral circulation. Catechol-O-methyltransferase (COMT) regulates cortical dopamine, and its activity can be influenced both genetically and pharmacologically. COMT ... -
A dose-effect network meta-analysis model: an application in antidepressants
(2021-04)Network meta-analysis (NMA) has been used to answer a range of clinical questions about the preferable intervention for a given condition. Although the effectiveness and safety of pharmacological agents depend on the dose ...