Browsing by Title
Now showing items 8-27 of 1185
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Absconding: reducing failure to return in adult mental health wards
(2016-11)Failing to return from leave from acute psychiatric wards can have a range of negative consequences for patients, relatives and staff. This study used quality improvement methodology to improve the processes around patient ... -
Absent sleep EEG spindle activity in GluA1 (Gria1) knockout mice: relevance to neuropsychiatric disorders
(2018-08)Sleep EEG spindles have been implicated in attention, sensory processing, synaptic plasticity and memory consolidation. In humans, deficits in sleep spindles have been reported in a wide range of neurological and psychiatric ... -
Abstract thinking as a risk factor for the development of posttraumatic stress disorder symptoms in student paramedics
(2021-10)Abstract cognitive processing is characterized by “why?” and “what if?” questions and associated with processes such as rumination and worry. The tendency to think abstractly in response to stress has not been examined as ... -
The Acceptability of a Smartphone App (BlueIce) for University Students Who Self-harm
(2022-01)University students are twice as likely to self-harm than community controls but, unfortunately, help-seeking among this population is particularly low. Given the stigma around self-harm, the face-to-face nature of traditional ... -
Acceptance and commitment therapy for psychosis: Current status, lingering questions and future directions.
(2023-06)Acceptance and Commitment Therapy for psychosis (ACTp) is a contextual behavioural intervention that promotes psychological flexibility by fostering active acceptance, cognitive defusion, values construction and committed ... -
Accuracy in recognising happy facial expressions is associated with antidepressant response to a NOP receptor antagonist but not placebo treatment
(2021-10)Background: Clinical trials with putative antidepressants can be difficult to execute as it can take up to 8 weeks before differences emerge between drug and placebo, and long expensive trials often fail. Implementation ... -
Accuracy of individual and combined risk-scale items in the prediction of repetition of self-harm: multicentre prospective cohort study
(2020-12)Background Individuals attending emergency departments following self-harm have increased risks of future self-harm. Despite the common use of risk scales in self-harm assessment, there is growing evidence that combinations ... -
Accuracy of risk scales for predicting repeat self-harm and suicide: a multicentre, population-level cohort study using routine clinical data
(2018-04-25)Background: Risk scales are used widely in the management of patients presenting to hospital following self-harm. However, there is evidence that their diagnostic accuracy in predicting repeat self-harm is limited. Their ... -
Accurate expression quantification from nanopore direct RNA sequencing with NanoCount
(2021-11)Accurately quantifying gene and isoform expression changes is essential to understanding cell functions, differentiation and disease. Sequencing full-length native RNAs using long-read direct RNA sequencing (DRS) has the ... -
Actigraphic patterns, impulsivity and moodinstability in bipolar disorder, borderlinepersonality disorder and healthy controls.
(2020-01)Objectives:To differentiate the relation between the structure and timing of rest-activity patterns and symptoms of impulsivity and mood instability in bipolar disorder (BD), borderline personality disorder(BPD) and healthy ... -
Actigraphy-derived physical activity levels and circadian rhythm parameters in patients with psoriatic arthritis: relationship with disease activity, mood, age and BMI
(2023-07)Background: Psoriatic arthritis (PsA) is associated with sleep disturbance, depression and a lifetime risk of obesity and cardiovascular disease. To date, there have been no studies investigating the relationship between ... -
Active Support and “meaningful activity.” What is the meaning of “meaningful”?
(2021-09)Active Support is an approach that aims to engage people in meaningful activities. It is one of the best evidenced models of support for adults with learning disabilities (Mansell and Beadle-Brown, 2012). Adults using ... -
Acute blood biomarker profiles predict cognitive deficits 6 and 12 months after COVID-19 hospitalization
(2023-08)Post-COVID cognitive deficits, including 'brain fog', are clinically complex, with both objective and subjective components. They are common and debilitating, and can affect the ability to work, yet their biological ... -
Acute mental health nurses’ experience of forcibly touching service users during physical restraint
(2020-10)Mental health nurses use forcible touch during physical restraint. Little research considers nurses’ experiences and the meanings they give to forcible touch. This study investigated nurses’ lived experiences of forcibly ... -
Acute neural effects of fluoxetine on emotional regulation in depressed adolescents
(2022-05)Adolescent major depressive disorder (MDD) is associated with disrupted processing of emotional stimuli and difficulties in cognitive reappraisal. Little is known however about how current pharmacotherapies act to modulate ... -
Adapted CBT to Stabilize Sleep on Psychiatric Wards: a Transdiagnostic Treatment Approach
(2018-04-04)Background: Almost all patients admitted at acute crisis to a psychiatric ward experience clinically significant symptoms of insomnia. Ward environments pose challenges to both sleep and the delivery of therapy. Despite ... -
Adapted problem adaptation therapy for depression in mild to moderate Alzheimer's disease dementia: A randomized controlled trial
(2024-03)Introduction: Trials of effectiveness of treatment options for depression in dementia are an important priority. Methods: Randomized controlled trial to assess adapted Problem Adaptation Therapy (PATH) for depression in ... -
Adapting cognitive behavioural therapy for adolescents with psychosis: insights from the Managing Adolescent first episode in psychosis study (MAPS)
(2022-01)Background: Onset of psychosis commonly occurs in adolescence, and long-term prognosis can be poor. There is growing evidence, largely from adult cohorts, that Cognitive Behavioural Therapy for Psychosis (CBTp) and ... -
Adaptive learning from outcome contingencies in eating-disorder risk groups
(2022-07)Eating disorders are characterised by altered eating patterns alongside overvaluation of body weight or shape, and have relatively low rates of successful treatment and recovery. Notably, cognitive inflexibility has been ... -
Adding value, reducing research waste, the role of the NHS research and development management community
(2018-02-23)Purpose – Research suggests that 85 per cent of health research is avoidably wasted. The research and development management community has an important role in the research process and can contribute to improving the ...