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No Association Between Amygdala Responses to Negative Faces and Depressive Symptoms: Cross-Sectional Data from 28,638 Individuals in the UK Biobank Cohort
(2022-07)In this Priority Data Letter, we report on the largest study to date to test the association between amygdala reactivity and depressive symptoms based on UK Biobank data. For transparency, we initially set out to investigate ... -
No benefit from flexible titration above minimum licensed dose in prescribing antidepressants for major depression: systematic review
(2019-12)Background In fixed‐dose antidepressant trials, the lower range of the licensed dose achieves the optimal balance between efficacy and tolerability. Whether flexible upward titration while side‐effects permit provides ... -
Non-pharamacological treatment for individuals with autism spectrum conditions who display harmful sexual behaviour
(2022-02)Background: Specific treatment and interventions for individuals with Autism Spectrum Conditions who display harmful sexual behaviour have yet to be widely evaluated. This review aims to consolidate and assess the quality ... -
Nurses' experiences of racism in mental health settings through patient and family interactions: A systematic review
(2024-03)Nursing staff engage readily with patients and associates in mental health/forensic inpatient settings. These settings are known to have instances of workplace violence directed towards staff and such violence includes ... -
Nursing Resilience Interventions - A way forward in challenging healthcare territories
(2020-04)Resilience in nursing must be viewed and acknowledged as a dynamic, fluid process that requires continuous nurturing and commitment, as well as adaptability and flexibility in the face of changing professional and personal ... -
Observational analysis of disparities in obesity in children in the UK: Has Leeds bucked the trend?
(2019-03)Background: The prevalence of obesity in childhood is of high concern, especially in deprived populations. We explored trends in obesity following the introduction of a citywide strategy focused on preschool children. Methods: ... -
Off–label long acting injectable antipsychotics in real–world clinical practice: a cross-sectional analysis of prescriptive patterns from the STAR Network DEPOT study
(2022-06)Introduction Information on the off–label use of Long–Acting Injectable (LAI) antipsychotics in the real world is lacking. In this study, we aimed to identify the sociodemographic and clinical features of patients treated ... -
One step closer to personalised prescribing of antidepressants: using real-world data together with patients and clinicians' preferences
(2019-07)Antidepressants for many decades have been shown to be an effective treatment for depressive disorder.1 Approximately 80% of people with depressive disorder in the UK will have been prescribed an antidepressant within the ... -
One thing leads to another: anticipating visual object identity based on associative-memory template
(2020-04)Probabilistic associations between stimuli afford memory templates that guide perception through pro-active anticipatory mechanisms. A great deal of work has examined the behavioural consequences and human electrophysiological ... -
An online experimental medicine trial on the effect of 28-day simvastatin administration on emotional processing, reward learning, working memory and salivary cortisol in healthy volunteers at risk for depression: OxSTEP protocol
(2023-06)Background: Evidence suggests inflammation may be a key mechanism by which psychosocial stress, including loneliness, predisposes to depression. Observational and clinical studies have suggested simvastatin, with its ... -
Online mood monitoring in treatment-resistant depression: qualitative study of patients' perspectives in the NHS
(2020-01)Aims and method True Colours is an automated symptom monitoring programme used by National Health Service psychiatric services. This study explored whether patients with unipolar treatment-resistant depression (TRD) found ... -
Online patient feedback as a measure of quality in primary care: a multimethod study using correlation and qualitative analysis
(2020-02)Objectives To ascertain the relationship between online patient feedback and the General Practice Patient Survey (GPPS) and the Friends and Family Test (FFT). To consider the potential benefit it may add by describing the ... -
Online patient feedback: a scoping review and stakeholder consultation
(2020-04)Objective To provide a synthesis of the current evidence base of online patient feedback using a scoping review and a consultation of stakeholders in England, UK. Methods We searched MEDLINE, EMBASE, PsycINFO, CINAHL ... -
Online peer support training to promote adolescents’ emotional support skills, mental health and agency during COVID-19: A pilot randomised controlled trial
(2021-08)Background: Adolescents often look to their peers for emotional support, so it is critical that they are prepared to take on a supportive role, especially during a health crisis. Using a pilot randomised controlled trial ... -
Online Social Endorsement and Covid-19 Vaccine Hesitancy in the United Kingdom
(2021-04)We explore the implications of online social endorsement for the Covid-19 vaccination program in the United Kingdom. Vaccine hesitancy is a long-standing problem, but it has assumed great urgency due to the pandemic. By ... -
An online survey of young adolescent girls’ use of the internet and smartphone apps for mental health support
(2018-07)Background Adolescents are digital natives, with the majority now owning their own smartphones and having internet access. Although the internet and smartphone applications (apps) can provide mental health support, little ... -
Onset and recurrence of psychiatric disorders associated with anti-hypertensive drug classes
(2021-05)The major anti-hypertensive (AHT) drug classes have been associated with differential risks of psychiatric disorders. However, existing data are limited largely to depression, and confounding variables have not always been ... -
Optimal dose of brexpiprazole for augmentation therapy of antidepressant-refractory depression: A systematic review and dose-effect meta-analysis
(2022-06)Background: Brexpiprazole augmentation is an effective treatment strategy for antidepressant-refractory depression, but its optimal dosage remains unclear. Aims: To find the optimal dosage of brexpiprazole as augmentation ... -
Out-of-area placements in acute mental health care: the outcomes
(2019-02)Out-of-area placements (OAPs) are heavily relied upon by the NHS to meet growing demand but they are expensive, disruptive for patients, and may reduce quality of care and outcomes for patients. Here, the authors compared ... -
Out-of-hours primary care end of life prescribing: a data linkage study
(2019-05)Objectives: Out-of-hours (OOH) primary care services are contacted in the last 4 weeks of life by nearly 30% of all patients who die, but OOH palliative prescribing remains poorly understood. Our understanding of prescribing ...