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Learning to Detect Bipolar Disorder and Borderline Personality Disorder with Language and Speech in Non-Clinical Interviews
(2020-08)Bipolar disorder (BD) and borderline personality disorder (BPD) are both chronic psychiatric disorders. However, their overlapping symptoms and common comorbidity make it challenging for the clinicians to distinguish ... -
Learning to optimize perceptual decisions through suppressive interactions in the human brain
(2019-01)Translating noisy sensory signals to perceptual decisions is critical for successful interactions in complex environments. Learning is known to improve perceptual judgments by filtering external noise and task-irrelevant ... -
Learning to optimize perceptual decisions through suppressive interactions in the human brain
(2019-01)Translating noisy sensory signals to perceptual decisions is critical for successful interactions in complex environments. Learning is known to improve perceptual judgments by filtering external noise and task-irrelevant ... -
Legal capacity and the right to decide: WHO QualityRights core training: mental health and social services: course guide
(2019)Ensuring mental health and well-being has become a worldwide imperative and an important target of the Sustainable Development Goals. But in all countries around the world, our response has been woefully insufficient, and ... -
Length of hospitalisation for people with severe mental illness: is the longer the better? Commentary on… Cochrane Corner
(2021)The Cochrane review in this month’s Cochrane Corner (Babalola 2014) compares short-stay hospital admission to long-stay/standard admission in patients with severe mental illness for a number of outcomes in a total 2030 ... -
A life more ordinary: A peer research method qualitative study of the Feeling Safe Programme for persecutory delusions
(2022-07)Background: The Feeling Safe Programme is a cognitive therapy developed to improve outcomes for individuals with persecutory delusions. It is theoretically driven, modular and personalised, with differences in ... -
Life problems in children and adolescents who self-harm: findings from the multicentre study of self-harm in England
(2022-01)Background: Self-harm, a significant and increasing global problem in children and adolescents, is often repeated and is associated with risk of future suicide. To identify potential interventions, we need to understand ... -
Lighthouse Parenting Programme: Description and pilot evaluation of Mentalization-Based Treatment (MBT) to address child maltreatment.
(2018)This paper introduces an innovative Mentalization - Based Treatment (MBT) parenting intervention for families where children are at risk of maltreatment. The Lighthouse MBT Parenting Programme aims to prevent child ... -
Linking the Mini-Mental State Examination, the Alzheimer’s Disease Assessment Scale–Cognitive Subscale and the Severe Impairment Battery: evidence from individual participant data from five randomised clinical trials of donepezil
(2020-10)Background The Mini-Mental State Examination (MMSE), the Alzheimer’s Disease Assessment Scale–Cognitive Subscale (ADAS-Cog) and the Severe Impairment Battery (SIB) are widely used rating scales to assess cognition in ... -
Lithium modulates striatal reward anticipation and prediction error coding in healthy volunteers
(2020-10)Lithium is one of the most effective mood-stabilizing medications in bipolar disorder. This study was designed to test whether lithium administration may stabilize mood via effects on reward processing. It was hypothesized ... -
Living network meta-analysis compared with pairwise meta-analysis in comparative effectiveness research: empirical study
(2018-02-28)Objective:To examine whether the continuous updating of networks of prospectively planned randomised controlled trials (RCTs) (“living” network meta-analysis) provides strong evidence against the null hypothesis in comparative ... -
Living well while providing support: validation of LTCQ-Carer for assessing informal carers’ quality of life
(2023-08)Despite international policies to support the health and wellbeing of informal (family) caregivers, there is no consensus on how to evaluate the effectiveness of carer support. We aimed to develop and validate a new ... -
Living with persistent insomnia after cancer: Aqualitative analysis of impact and management
(2020-06)Objectives.To conduct a qualitative exploration of the lived experience of insomniadisorder and its management amongst a sample of mixed-diagnoses cancer survivors.Methods.Twenty-seven cancer survivors with persistent ... -
Long COVID rehabilitation: A collaborative approach to managing a new phenomenon
(2022-02)Purpose: Post COVID Syndrome (Long COVID) is the continuation of symptoms related to a COVID-like-illness after 12 weeks post onset (NICE Guidelines December 2020). Most recent ONS prevalence data (April 2021) predicts ... -
Long read sequencing reveals novel isoforms and insights into splicing regulation during cell state changes
(2021-04)Alternative splicing (AS) is a key mechanism underlying cellular differentiation and a driver of complexity in mammalian neuronal tissues. However, understanding of which isoforms are differentially used or expressed and ... -
Longitudinal Changes in Parkinson’s Disease Symptoms with and Without Rapid Eye Movement Sleep Behavior Disorder: The Oxford Discovery Cohort Study
(2021-08)Background: Parkinson’s disease (PD) comorbid with rapid eye movement sleep behavior disorder (RBD) may show more severe motor and non motor symptoms, suggesting a distinct PD subtype. Objective: The aim of this study was ... -
Longitudinal cognitive performance in patients with Bipolar Disorder
(2020-01)Commentary: Neurocognitive impairments are a rather common occurrence in euthymic Bipolar Disorder (BD) patients. Understanding the degree of longitudinal stability of these deficits is vital in the management and treatment ... -
Longitudinal trajectory of cardiac magnetic resonance and cardiopulmonary exercise testing findings in moderate to severe COVID-19 and association with symptoms
(2021-10)Background Cardiac magnetic resonance (CMR) and cardiopulmonary exercise testing (CPET) have provided important insights into the prevalence of early cardiopulmonary abnormalities in COVID-19 patients. It is currently ... -
Long‐term benefits of digital cognitive behavioural therapy for insomnia: Follow‐up report from a randomized clinical trial
(2020-02)Digital cognitive behavioural therapy (dCBT) is an effective treatment for chronic insomnia and also improves well‐being and quality of life (QoL). We assessed whether these benefits are sustained and if the effects of ... -
Looking ahead in working memory to guide sequential behaviour
(2021-06)Working memory can maintain multiple sensory representations to serve unfolding sequential behaviour, such as while making tea or planning a route. How the human mind juggles internal representations as they become relevant ...