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Association of midlife stroke risk with structural brain integrity and memory performance at older ages: a longitudinal cohort study
(2020-03)
Cardiovascular health in midlife is an established risk factor for cognitive function later in life. Knowing mechanisms of this associationmay allow preventative steps to be taken to preserve brain health and cognitive ...
The effects of small-needle-knife therapy on pain and mobility from knee osteoarthritis: a pilot randomized-controlled study
(2020-06)
Objective:To investigate the effect of small needle-knife therapy in people with painful knee osteoarthritis.
Design:Pilot randomised, controlled trial.
Setting:Rehabilitation hospital.
Subjects:In-patients with ...
Neurophysiological signatures of hand motor response to dual-transcranial direct current stimulation in subacute stroke: a TMS and MEG study
(2020-06)
Background:Dual transcranial direct current stimulation (tDCS) to the bilateral primary motor cortices (M1s) has potential benefits in chronic stroke, but its effects in subacute stroke, when behavioural effects might be ...
Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial
(2020-07)
Background
The pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) might be curtailed by vaccination. We assessed the safety, reactogenicity, and immunogenicity of a viral vectored coronavirus vaccine ...
Translating the Strengthening and Stretching for Rheumatoid Arthritis of the Hand Programme from clinical trial to clinical practice: An effectiveness–implementation study
(2020-09)
Introduction
The Strengthening and Stretching for Rheumatoid Arthritis of the Hand programme is a hand exercise programme for people with rheumatoid arthritis. It was clinically effective when delivered during a clinical ...
Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind, randomised, controlled, phase 2/3 trial
(2020-12)
Background
Older adults (aged ≥70 years) are at increased risk of severe disease and death if they develop COVID-19 and are therefore a priority for immunisation should an efficacious vaccine be developed. Immunogenicity ...
Changing paramedic students' perception of people who self-harm
(2020-10)
This study aimed to identify whether paramedic students' perceptions of patients who self-harm changed following an educational intervention.
Background:
Self-harm is a major public health concern with an increasing ...
Postnatal depression in fathers: a quiet struggle?
(2020-11)
The mental health of fathers is now receiving more attention as a part of a national policy designed to address mens' mental health. Fatherhood can be a challenging period in a man's life and some men are at risk of ...
Phase 1/2 trial of SARS-CoV-2 vaccine ChAdOx1 nCoV-19 with a booster dose induces multifunctional antibody responses
(2020-12)
More than 190 vaccines are currently in development to prevent infection by the novel severe acute respiratory syndrome coronavirus 2. Animal studies suggest that while neutralizing antibodies against the viral spike protein ...
Functional organisation for verb generation in children with developmental language disorder
(2020-12)
Developmental language disorder (DLD) is characterised by difficulties in learning one's native language for no apparent reason. These language difficulties occur in 7% of children and are known to limit future academic ...