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Prevalence, predictors, and prognosis of symptomatic intracranial stenosis in patients with transient ischaemic attack or minor stroke: a population-based cohort study
(2020-05)
Symptomatic intracranial stenosis was perceived to convey a high risk of recurrent stroke, but two previous trials (SAMMPRIS and VISSIT) did not show superiority of intracranial stenosis stenting over intensive medical ...
Effect of the NMDA receptor partial agonist, d-cycloserine, on emotional processing and autobiographical memory
(2020-04)
Background: Studies suggest that d-cycloserine (DCS) may have antidepressant potential through its interaction with the glycine site of the N-Methyl-D-aspartate receptor (NMDAR); however clinical evidence of DCS’s efficacy ...
How representative are neuroimaging samples? Large-scale evidence for trait anxiety differences between MRI and behaviour-only research participants.
(2020-04)
Over the past three decades, MRI has become a key tool to study how cognitive processes are implemented in the human brain. However, the question of whether participants recruited into MRI studies differ from participants ...
Why do patients with psychosis listen to and believe derogatory and threatening voices? 2 21 reasons given by patients
(2020-05)
Background: Around two thirds of patients with auditory hallucinations experience derogatory
37 and threatening voices (DTVs). Understandably, when these voices are believed then common
38 consequences can be depression, ...
Comparative efficacy and acceptability of antidepressants, psychotherapies, and their combination for acute treatment of children and adolescents with depressive disorder: a systematic review and network meta-analysis
(2020-07)
Depressive disorders are common in children and adolescents. Antidepressants, psychotherapies, and their combination are often used in routine clinical practice; however, available evidence on the comparative efficacy and ...
Physical activity in a pandemic: A new treatment target for psychological therapy.
(2020-06)
The COVID-19 pandemic and its management are placing significant new strains onpeople’s well-being, particularly those with pre-existing mental health conditions. Physicalactivity has been shown to improve mental as well ...
Cognition in Mood Disorders
(2020-01)
Mood disorders are common, complex, and one of the main causes of morbidity worldwide (1).
There has been an increasing recognition that cognitive dysfunction is a central aspect of most
mood disorders, as well as being ...
Safety of 80 antidepressants, antipsychotics, anti-attention-deficit/ hyperactivity medications and mood stabilizers in children and adolescents with psychiatric disorders: a large scale systematic meta-review of 78 adverse effects
(2020-06)
Mental disorders frequently begin in childhood or adolescence. Psychotropic medications have various indications for the treatment of mental disorders in this age group and are used not infrequently off‐label. However, ...
Natural language processing for structuring clinical text data on depression using UK-CRIS
(2020-02)
Background Utilisation of routinely collected electronic health records from secondary care offers unprecedented possibilities for medical science research but can also present difficulties. One key issue is that medical ...