Browsing Conditions by Title
Now showing items 11-30 of 698
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Actigraphy-derived physical activity levels and circadian rhythm parameters in patients with psoriatic arthritis: relationship with disease activity, mood, age and BMI
(2023-07)Background: Psoriatic arthritis (PsA) is associated with sleep disturbance, depression and a lifetime risk of obesity and cardiovascular disease. To date, there have been no studies investigating the relationship between ... -
Acute neural effects of fluoxetine on emotional regulation in depressed adolescents
(2022-05)Adolescent major depressive disorder (MDD) is associated with disrupted processing of emotional stimuli and difficulties in cognitive reappraisal. Little is known however about how current pharmacotherapies act to modulate ... -
Adapted problem adaptation therapy for depression in mild to moderate Alzheimer's disease dementia: A randomized controlled trial
(2024-03)Introduction: Trials of effectiveness of treatment options for depression in dementia are an important priority. Methods: Randomized controlled trial to assess adapted Problem Adaptation Therapy (PATH) for depression in ... -
Adaptive learning from outcome contingencies in eating-disorder risk groups
(2022-07)Eating disorders are characterised by altered eating patterns alongside overvaluation of body weight or shape, and have relatively low rates of successful treatment and recovery. Notably, cognitive inflexibility has been ... -
Addressing concerns about smoking cessation and mental health: theoretical review and practical guide for healthcare professionals
(2020-07)Smoking rates in people with depression and anxiety are twice as high as in the general population, even though people with depression and anxiety are motivated to stop smoking. Most healthcare professionals are aware that ... -
Adjunctive Psychotherapy for Bipolar Disorder A Systematic Review and Component Network Meta-analysis
(2020-10)Importance Several psychotherapy protocols have been evaluated as adjuncts to pharmacotherapy for patients with bipolar disorder, but little is known about their comparative effectiveness. Objective To use systematic ... -
Advances in the computational understanding of mental illness
(2020-07)Computational psychiatry is a rapidly growing field attempting to translate advances in computational neuroscience and machine learning into improved outcomes for patients suffering from mental illness. It encompasses both ... -
Affective bias as a rational response to the statistics of rewards and punishments
(2017-10)Affective bias, the tendency to differentially prioritise the processing of negative relative to positive events, is commonly observed in clinical and non-clinical populations. However, why such biases develop is not known. ... -
Agoraphobic avoidance in patients with psychosis: Severity and response to automated VR therapy in a secondary analysis of a randomised controlled clinical trial
(2022-11)Background: The social withdrawal of many patients with psychosis can be conceptualised as agoraphobic avoidance due to a range of long-standing fears. We hypothesised that greater severity of agoraphobic avoidance is ... -
The alarms should no longer be ignored: A Survey of the Demand, Capacity and Provision of Adult Community Eating Disorder Services in England and Scotland before COVID-19
(2022-12)This national survey compared the demand and capacity of adult community eating disorder services (ACEDS) to NHSE Commissioning guidance. Results: Of 21 services approached in England and Scotland 13 responded (10.7 million ... -
Anticipating PTSD in severe COVID survivors: the case for screen-and-treat
(2022-01)Based on research from previous pandemics, studies of critical care survivors, and emerging COVID19 data, we estimate that up to 30% of survivors of severe COVID will develop PTSD. PTSD is frequently undetected across ... -
Anticipatory Pleasure in Current Psychosis: Cognitive and Emotional Correlates
(2020-12)Anticipation of pleasure – a key aspect of hedonic experience - is a motivating factor for engaging in activities. Low levels of anticipatory pleasure and activity are found in individuals with psychosis. Cognitive factors ... -
Antidepressants might work for people with major depression: where do we go from here? (Comment)
(2018-06)The publication of our updated network meta-analysis about antidepressants for the acute treatment of major depression has generated a wide discussion in newspapers, social media, and scientific journals. Based on 522 ... -
Antidepressants plus benzodiazepines in major depressive disorder: a clinical dilemma with no recent answers from research
(2020-10)Comorbid anxiety symptoms are common in depression, and adding benzodiazepines to antidepressant treatment may seem a rational clinical solution. Benzodiazepines also have potential to reduce the initial anxiety that may ... -
Antimicrobial Peptides SLPI and Beta Defensin-1 in Sputum are Negatively Correlated with FEV1
(2021-05)Background: Chronic obstructive pulmonary disease (COPD) and asthma have heterogeneous inflammation with inhaled corticosteroids (ICS) as a mainstay of treatment. There is increased prevalence of non-typeable Haemophilus ... -
Antipsychotic medication versus psychological intervention versus a combination of both in adolescents with first-episode psychosis (MAPS): a multicentre, three-arm, randomised controlled pilot and feasibility study
(2020-07)Background Evidence for the effectiveness of treatments in early-onset psychosis is sparse. Current guidance for the treatment of early-onset psychosis is mostly extrapolated from trials in adult populations. The UK ... -
APOE genotype and cognition in healthy individuals at risk of Alzheimer's disease: A review
(2018-07)APOE-ε4 is best known as a risk factor for Alzheimer's disease (AD). Consequently, there is considerable research interest in understanding whether APOE-ε4 influences cognition in healthy adults. Despite a substantial ... -
Appraisal Biases About Strangers in Posttraumatic Stress Disorder
(2019-02)Cognitive theories of posttraumatic stress disorder (PTSD) suggest that negative appraisals play an important role in the development and maintenance of PTSD. It has not yet been examined experimentally how people with ... -
Appraisal of patient-level health economic models of severe mental illness: systematic review
(2021-08)Healthcare decision makers require accurate long-term economic models to evaluate the cost-effectiveness of new mental health interventions. Aims To assess the suitability of current patient-level economic models to ... -
Are benzodiazepines effective in treating catatonia?
(2020-12)Establishing an evidence base for the clinical management of catatonia is made difficult by the heterogeneous nature of the condition and the limited understanding of its pathophysiology. Benzodiazepines are a mainstay of ...