Browsing Schizophrenia and Psychotic Disorders by Issue Date
Now showing items 21-40 of 126
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Automated virtual reality (VR) cognitive therapy for patients with psychosis: study protocol for a single-blind parallel group randomised controlled trial (gameChange).
(2019-08)Introduction Many patients with psychosis experience everyday social situations as anxiety-provoking. The fears can arise, for example, from paranoia, hallucinations, social anxiety or negative-self beliefs. The fears lead ... -
The comments of voices on the appearance of patients with psychosis: ‘the voices tell me that I am ugly’
(2019-09)Background:There are high rates of obesity and low self-esteem in patients with psychosis. The occurrence of negative voice content directly about appearance is therefore plausible. Derogatory comments about appearance are ... -
The weeks before 100 persecutory delusions: the presence of many potential contributory causal factors
(2019-09)Background:The period before the formation of a persecutory delusion may provide causal insights. Patient accounts are invaluable in informing this understanding. Aims:To inform the understanding of delusion formation, ... -
Is adjunctive CBT really effective for schizophrenia?
(2019-09)Although antipsychotic medication remains the mainstay of treatment for schizophrenia, medications alone are not always successful. Cognitive– behavioural therapy (CBT) is recommended as an adjunct to pharmacological ... -
Autoimmune psychosis: an international consensus on an approach to the diagnosis and management of psychosis of suspected autoimmune origin
(2019-10)There is increasing recognition in the neurological and psychiatric literature of patients with so-called isolated psychotic presentations (ie, with no, or minimal, neurological features) who have tested positive for ... -
Comparative effects of 18 antipsychotics on metabolic function in schizophrenia, predictors of metabolic dysregulation, and association with psychopathology: a systematic review and network meta-analysis
(2019-10)Background: Antipsychotic-treatment is associated with metabolic disturbance. However, the relative degree to which metabolic alterations occur in treatment with different antipsychotics remains unclear. Furthermore, ... -
The tail wagging the dog: the diagnostic accuracy of first rank symptoms COMMENTARY ON… COCHRANE CORNER
(2019-10)Outcomes for people with schizophrenia are improved by expedient diagnosis and specific treatment. ICD-11 and DSM-5 have reduced the importance of Schneider's first rank symptoms (FRS) in the diagnosis of schizophrenia; ... -
Understanding, treating, and renaming grandiosedelusions: A qualitative study
(2019-11)Background.Grandiose delusions are arguably the most neglected psychotic experience in research. Objectives.We aimed to discover from patients: whether grandiose delusions have harmful consequences; the psychological ... -
Violent outcomes in first-episode psychosis: A clinical cohort study
(2019-11)Aim Violence risk is an important part of a comprehensive clinical assessment in first‐episode psychosis. This study addresses limitations of previous violent outcome research in first‐episode psychosis, which has typically ... -
The side effect profile of Clozapine in real world data of three large mental hospitals
(2020-01)Objective: Mining the data contained within Electronic Health Records (EHRs) can potentially generate a greater understanding of medication effects in the real world, complementing what we know from Randomised control ... -
Examination of the neural basis of psychotic-like experiences in adolescence during processing of emotional faces
(2020-03)Contemporary theories propose that dysregulation of emotional perception is involved in the aetiology of psychosis. 298 healthy adolescents were assessed at age 14- and 19-years using fMRI while performing a facial emotion ... -
Development of the Ketamine Side Effect Tool
(2020-04)Background: Currently, no specific, systematic assessment tool for the monitoring and reporting of ketamine-related side effects exists. Our aim was to develop a comprehensive Ketamine Side Effect Tool (KSET) to capture ... -
Developing an automated VR cognitive treatment for psychosis: gameChange VR therapy
(2020-04)The automated delivery of psychological treatment using virtual reality (VR) has the potential to revolutionise patient access to evidence-based care. VR creates immersive, interactive computer simulations, which elicit ... -
Why do patients with psychosis listen to and believe derogatory and threatening voices? 2 21 reasons given by patients
(2020-05)Background: Around two thirds of patients with auditory hallucinations experience derogatory 37 and threatening voices (DTVs). Understandably, when these voices are believed then common 38 consequences can be depression, ... -
Virtual reality clinical-experimental tests of compassion treatment techniques to reduce paranoia
(2020-05)Paranoia may build on negative beliefs held both about the self and others. Compassionate imagery may be one way of reducing such negative beliefs, and hence paranoia. Two studies tested this idea, one targeting compassion ... -
Hemizygous mutations in L1CAM in two unrelated male probands with childhood onset psychosis
(2020-06)Objective :To identify genes underlying childhood onset psychosis. Methods :Patients with onset of psychosis at age 13 or younger were identified from clinics across England, and they and their parents were exome sequenced ... -
Fear of illness recurrence and mental healthanxiety in people recovering from psychosis andcommon mental health problems
(2020-06)Objectives: It is well known that mental health problems can recur even after effective treatment, leading to an understandable fear of illness recurrence (FIR) and mental health anxiety (MHA). These may themselves contribute ... -
Clinicians’ views of treatment types for first episode psychosis delivered in a randomised controlled trial (MAPS)
(2020-07)Background Clinicians’ treatment beliefs could affect the feasibility of delivering different treatments in a randomised controlled trial (RCT). In MAPS (Managing Adolescent first Episode Psychosis: a feasibility Study), ... -
Measuring reasoning in paranoia: Development of the Fast and Slow Thinking Questionnaire
(2020-07)Paranoid thoughts are common across the psychosis continuum. It is well established that reasoning biases (conceived as an overreliance on fast thinking and lack of willingness and/or ability to engage in slow thinking) ...