Critical Developmental Windows of Voltage-Gated Cation Channel Expression in Psychiatric Disorders
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Noura Al-Jouffali. Critical Developmental Windows of Voltage-Gated Cation Channel Expression in Psychiatric Disorders. Biological Psychiatry. VOLUME 90, ISSUE 6, E31-E32, SEPTEMBER 15, 2021
The molecular underpinnings of psychiatric disorders remain elusive despite there being a paramount need to establish druggable targets for their treatment. Genome-wide association studies (GWASs) have identified numerous candidate genes implicated in the pathology of psychiatric disorders. However, a key challenge is to identify time intervals when implicated biological pathways are germane. This information is critical from a drug development perspective because it guides when psychopharmacotherapy should be applied to achieve maximum effect.
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