Conditions: Recent submissions
Now showing items 641-660 of 698
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Appraisal Biases About Strangers in Posttraumatic Stress Disorder
(2019-02)Cognitive theories of posttraumatic stress disorder (PTSD) suggest that negative appraisals play an important role in the development and maintenance of PTSD. It has not yet been examined experimentally how people with ... -
Subchronic treatment with St John’s wort produces a positive shift in emotional processing in healthy volunteers
(2018-11-28)The neurocognitive model of antidepressant treatment in depression states that antidepressants work by producing relatively immediate positive shifts in emotional processing, which translate into clinical improvement with ... -
Automated psychological therapy using virtual reality (VR) for patients with persecutory delusions: study protocol for a single-blind parallel-group randomised controlled trial (THRIVE)
(2019-01)Persecutory delusions are a major psychiatric problem and are associated with a wide range of adverse outcomes. Our theoretical model views these delusions as unfounded threat beliefs which persist due to defence behaviours ... -
Effect of Assertive Community Treatment for Patients with Substance Use Disorder: A Systematic Review
(2019-01-30)Substance use disorders (SUD) are an important health issue internationally. Traditional outpatient programmes often do not adequately address the substantial medical and social needs and in addition many patients ... -
Investigation of the impact of total sleep deprivation at home on the number of intrusive memories to an analogue trauma
(2019-02)Sleep enhances the consolidation of memory; however, this property of sleep may be detrimental in situations where memories of an event can lead to psychopathology, such as following a traumatic event. Intrusive memories ... -
What is the relationship between dissociation and self-harming behaviour in adolescents?
(2019-01)Deliberate self‐harm in adolescents is an increasing clinical problem, but there is a limited understanding of the mechanisms causing or maintaining this behaviour. One proposed mechanism is that of dissociation. However, ... -
Effectiveness of Vitamin D Supplementation in the Management of Multiple Sclerosis: A Systematic Review
(2019-03)The main objective was to examine the extent of effect vitamin D in Multiple Sclerosis (MS) on pathology and symptoms. A literature search was performed in November 2018 (CRD42018103615). Eligibility criteria: randomised ... -
Barriers and facilitators to implementing dementia care mapping in care homes: results from the DCM™ EPIC trial process evaluation
(2019-02)Background: Psychosocial person-centred interventions are considered best practice for addressing complex behaviours and care needs such as agitation and anxiety, and for improving the quality of life of people with ... -
Development and validation of a prediction model for the probability of responding to placebo in antidepressant trials: a pooled analysis of individual patient data
(2019-02)Background: Identifying potential placebo responders among apparent drug responders is critical to dissect drug-specific and nonspecific effects in depression. Objective: This project aimed to develop and test a prediction ... -
A single dose of fluoxetine reduces neural limbic responses to anger in depressed adolescents
(2019-01-21)Depression in adolescence is frequently characterised by symptoms of irritability. Fluoxetine is the antidepressant with the most favourable benefit:risk ratio profile to treat adolescent depression, but the neural ... -
The experience of feeling fat for women with anorexia nervosa: An interpretative phenomenological analysis
(2019-01)Feeling fat has been implicated as a maintenance factor in anorexia nervosa (AN), despite limited research into the experience. This study expanded the literature by exploring the lived experience of feeling fat for ... -
Comparative economic evaluation of quetiapine plus lamotrigine combination vs quetiapine monotherapy (and folic acid vs placebo) in patients with bipolar depression (cequel)
(2018-12)Although not licensed for acute bipolar depression, lamotrigine has evidence for efficacy in trials and its use is recommended in guidelines. So far there had been no prospective health economic evaluation of its use. ... -
A signature-based machine learning model for distinguishing bipolar disorder and borderline personality disorder
(2018)Mobile technologies offer new opportunities for prospective, high resolution monitoring of long-term health conditions. The opportunities seem of particular promise in psychiatry where diagnoses often rely on retrospective and ... -
The effects of incretin‐based therapies on β‐cell function and insulin resistance in type 2 diabetes: A systematic review and network meta‐analysis combining 360 trials
(2018-12-09)Aim To evaluate the comparative effects of incretin‐based therapies, including glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) and dipeptidyl peptidase‐4 inhibitors (DPP‐4Is), on β‐cell function and insulin resistance ... -
Vitamin D, bone mineral density and risk of fracture in people with intellectual disabilities
(2018-12)Background: People with intellectual disabilities (IDs) have very high rates of osteoporosis and fractures, to which their widespread vitamin D deficiency and other factors could contribute. We aimed to assess in people ... -
Vortioxetine for depression: the evidence for its current use in the UK: COMMENTARY ON… COCHRANE CORNER
(2018-12-17)The pharmacological treatment of depression is often hampered by side-effects and unsatisfactory response to treatment. Vortioxetine is one of the newest antidepressants on the market, purportedly with a different mechanism ... -
Changes in brain Glx in depressed bipolar patients treated with lamotrigine: A proton MRS study
(2019-03)Background Lamotrigine is a useful treatment in bipolar depression but requires several weeks of dose titration before its clinical effects can be assessed. Animal experimental studies suggest that lamotrigine lowers ... -
The Role of Self-Management Practices as Mechanisms for Re-Establishing Normality in Cancer Survivors
(2016)This article explores the relationship between cancer survivors' use of self-management practices and their search for normality. Using Frank's illness narratives and other theoretical literature on normality in chronic ... -
Care needs of people with dementia in the peri-operative environment: A systematic review
(2018-11)The care of people with dementia within the hospital setting is challenging for healthcare professionals. Hospital design and services are not optimized for people with dementia, owing to the lack of preparation of healthcare ... -
‘Are they just gonna reject me?’ Male adolescents with autism making sense of anxiety: An Interpretative Phenomenological Analysis
(2018-07)Anxiety can be a significant difficulty for people with autism, and rates increase during childhood and early adolescence. Nevertheless, little is known about the subjective experience of anxiety in this population. This ...