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Now showing items 71-80 of 88
Grey matter microstructural differencesin developmental stuttering
(2021-03)
Theoretical accounts of developmental stuttering implicate dysfunctional cortico-striatal-thalamo-cortical motor loops through the putamen, but empirical evidence of these proposed differences is currently limited. ...
Longitudinal Changes in Parkinson’s Disease Symptoms with and Without Rapid Eye Movement Sleep Behavior Disorder: The Oxford Discovery Cohort Study
(2021-08)
Background: Parkinson’s disease (PD) comorbid with rapid eye movement sleep behavior disorder (RBD) may show more severe motor and non motor symptoms, suggesting a distinct PD subtype. Objective: The aim of this study was ...
Suicidal Thoughts in Patients With Cancer and Comorbid Major Depression: Findings From a Depression Screening Program
(2021-09)
Major depression is found in around ten percent of patients attending cancer clinics. One of the symptoms of major depression, defined in the Diagnostic and Statistical Manual of Mental Disorders (DSM), is “thoughts of ...
Characterising the severity of treatment resistance in unipolar and bipolar depression
(2021-10)
Treatment-resistant depression (TRD) is classically defined according to the number of suboptimal antidepressant responses experienced, but multidimensional assessments of TRD are emerging and may confer some advantages. ...
Exercise versus usual care after non-reconstructive breast cancer surgery (UK PROSPER): multicentre randomised controlled trial and economic evaluation
(2021-11)
Objective To evaluate whether a structured exercise programme improved functional and health related quality of life outcomes compared with usual care for women at high risk of upper limb disability after breast cancer ...
International Multicenter Analysis of Brain Structure Across Clinical Stages of Parkinson’s Disease
(2021-06)
ABSTRACT: Background: Brain structure abnormalities throughout the course of Parkinson’s disease have
yet to be fully elucidated.
Objective: Using a multicenter approach and harmonized analysis methods, we aimed to shed ...
Extended follow-up of a short total diet replacement programme: results of the Doctor Referral of Overweight People to Low Energy total diet replacement Treatment (DROPLET) randomised controlled trial at 3 years
(2021-07)
To test the long-term effectiveness of a total diet replacement programme (TDR) for routine treatment of obesity in a primary care setting.
Methods
This study was a pragmatic, two-arm, parallel-group, open-label, ...
Neurons derived from individual early Alzheimer’s disease patients reflect clinical vulnerability
(2021-11)
Modelling sporadic Alzheimer’s disease (sAD) with patient-derived induced pluripotent stem
cells (iPSCs) is challenging yet remains an important step in understanding the disease. Here
we report a novel approach of sAD ...
Brain tumour segmentation using a triplanar ensemble of U-Nets on MR images
(2021-05)
Gliomas appear with wide variation in their characteristics
both in terms of their appearance and location on brain MR images,
which makes robust tumour segmentation highly challenging, and leads
to high inter-rater ...
Investigating the Mechanisms of Graded Sensorimotor Precision Training in Adults With Chronic Nonspecific Low Back Pain: Protocol for a Causal Mediation Analysis of the RESOLVE Trial
(2021-07)
Chronic low back pain (CLBP) is a global health problem associated with an increasing burden on individuals, health care systems, and society. Common treatments for people with CLBP produce, on average, small short-term ...