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Side effect profile and comparative tolerability of 21 antidepressants in the acute treatment of major depression in adults: protocol for a network meta-analysis
(2019-05)
Introduction: We have recently compared all second-generation as well as selected first-generation antidepressants in terms of efficacy and acceptability in the acute treatment of major depression. Here we present a protocol ...
Association of Cannabis Use in Adolescence and Risk of Depression, Anxiety, and Suicidality in Young Adulthood A Systematic Review and Meta-analysis
(2019-02)
Cannabis is the most commonly used drug of abuse by adolescents in the world. While the impact of adolescent cannabis use on the development of psychosis has been investigated in depth, little is known about the impact of ...
Measuring Disturbance of the Endocannabinoid System in Psychosis A Systematic Review and Meta-analysis
(2019-06)
Importance: The endocannabinoid system (ECS) is a lipid-based endogenous signaling system. Its relevance to psychosis is through the association between cannabis use and the onset and course of illness and through the ...
Effectiveness and Acceptability of Cognitive Behavior Therapy Delivery Formats in Adults With Depression A Network Meta-analysis
(2019-04)
Importance Cognitive behavior therapy (CBT) has been shown to be effective in the treatment of acute depression. However, whether CBT can be effectively delivered in individual, group, telephone-administered, guided ...
Changes in brain Glx in depressed bipolar patients treated with lamotrigine: A proton MRS study
(2019-03)
Background
Lamotrigine is a useful treatment in bipolar depression but requires several weeks of dose titration before its clinical effects can be assessed. Animal experimental studies suggest that lamotrigine lowers ...
Ketamine for Psychiatric Disorders
(2019-07)
This new edition of The ECT Handbook comes six years after the publication of the 3rd edition. In the intervening period there have been no major changes in the practice of electroconvulsive therapy, but continuing research ...
Investigation of the impact of total sleep deprivation at home on the number of intrusive memories to an analogue trauma
(2019-02)
Sleep enhances the consolidation of memory; however, this property of sleep may be detrimental in situations where memories of an event can lead to psychopathology, such as following a traumatic event. Intrusive memories ...
Trends in antidepressant prescriptions in children and young people in England, 1998–2017: protocol of a cohort study using linked primary care and secondary care datasets
(2019-06)
Introduction: Increasing numbers of children and young people (CYP) are receiving prescriptions for antidepressants. This is the protocol of a study aiming to describe the trends and variation in antidepressant prescriptions ...
What is the relationship between dissociation and self-harming behaviour in adolescents?
(2019-01)
Deliberate self‐harm in adolescents is an increasing clinical problem, but there is a limited understanding of the mechanisms causing or maintaining this behaviour. One proposed mechanism is that of dissociation. However, ...
Observational analysis of disparities in obesity in children in the UK: Has Leeds bucked the trend?
(2019-03)
Background: The prevalence of obesity in childhood is of high concern, especially
in deprived populations. We explored trends in obesity following the introduction
of a citywide strategy focused on preschool children.
Methods: ...