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No benefit from flexible titration above minimum licensed dose in prescribing antidepressants for major depression: systematic review
(2019-12)
Background
In fixed‐dose antidepressant trials, the lower range of the licensed dose achieves the optimal balance between efficacy and tolerability. Whether flexible upward titration while side‐effects permit provides ...
Subclinical anxiety and depression are associated with deficits in attentional target facilitation, not distractor inhibition
(2019-06)
Mood and anxiety disorders are associated with deficits in attentional control
involving emotive and non-emotive stimuli. Current theories focus on impaired
attentional inhibition of distracting stimuli in producing these ...
Suicidal ideation and behaviour in patients with persecutory delusions: Prevalence, symptom associations, and psychological correlates
(2019-07)
Background:To determine the prevalence of suicidal ideation and behaviour - and their correlates - in patients with persecutory delusions.
Methods:110 patients with persecutory delusions in the context of non-affective ...
Value of monitoring negative emotional bias in primary care in England for personalised antidepressant treatment: a modelling study
(2019-11)
Depressed patients often focus on negative life events. Effective antidepressant therapy reverses this negative emotional bias (NEB) within 1 week. Clinical therapeutic effect usually requires 4–6 weeks. The value of ...
Personalise antidepressant treatment for unipolar depression combining individual choices, risks and big data (PETRUSHKA): rationale and protocol
(2019-10)
Introduction: Matching treatment to specific patients is too often a matter of trial and error, while treatment efficacy should be optimised by limiting risks and costs and by incorporating patients’ preferences. Factors ...
Protocol for a systematic review of the pharmacological augmentation treatment guidelines for unipolar depression
(2019-11)
Objectives: To provide a comprehensive overview of recommendations made by local, national and international
bodies for the prescription of pharmacological augmentation therapies for TRD, to identify consistencies ...
Treatment for depression comorbid with dementia
(2019-11)
Depression is a common comorbidity in dementia. Randomised controlled studies of antidepressants do not show a significant improvement in depressive symptoms in patients with comorbid dementia and are known to lead to an ...
ENIGMA MDD: Seven Years of Global Neuroimaging Studies of Major Depression through Worldwide Data Sharing
(2019-10)
A key objective in the field of translational psychiatry over the past few decades has been to
identify the brain correlates common to individuals with major depressive disorder (MDD).
Identifying measurable indicators ...
Cognitive Impairment in Patients with Bipolar Disorder: Impact of Pharmacological Treatment
(2019-12)
Bipolar disorder is an illness characterised by periods of elated and depressed mood. These mood episodes are associated with changes in cognitive function and there is evidence to suggest that cognitive dysfunction persists ...