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Targeting synaptic plasticity in schizophrenia: insights from genomic studies
(2021-08)
Recent genomic findings identify many hundreds of genomic loci that are associated with schizophrenia.
Consistent with data from the pregenomic era, genomic findings implicate synaptic function and plasticity as a tractable ...
Brain glutamate concentration in men with early psychosis: a magnetic resonance spectroscopy case–control study at 7 T
(2021-06)
Abnormalities in glutamate neurotransmission are linked to psychotic symptoms and cognitive dysfunction in schizophrenia. magnetic resonance spectroscopy (MRS) provides an acceptable means of measuring glutamate in the ...
The impact of Patient and Public Involvement in the SlowMo study: Reflections on peer innovation
(2021-09)
Background: The SlowMo study demonstrated the effects of SlowMo, an eight-session digitally supported reasoning intervention, on paranoia in a large-scale randomized-controlled trial with 362 participants with schizophre ...
Weight change, cardio-metabolic risk factors and cardiovascular incidence in people with serious mental illness: protocol of a population-based cohort study in the UK from 1998 to 2020
(2021-11)
Introduction: People with serious mental illness (SMI), which includes people with diagnoses of schizophrenia spectrum and bipolar disorders, face significant health inequality. This includes a life expectancy reduced by ...
Identifying effective characteristics of behavioral weight management interventions for people with serious mental illness: A systematic review with a qualitative comparative analysis
(2021-10)
People with serious mental illness (SMI) have identified barriers to engaging in behavioral weight management interventions (BWMIs). We assessed whether BWMIs that addressed these barriers were more effective. First, we ...
Kalirin as a Novel Treatment Target for Cognitive Dysfunction in Schizophrenia
(2021-12)
The cognitive dysfunction experienced by patients with schizophrenia represents a major unmet clinical need. We believe that enhancing synaptic function and plasticity by targeting kalirin may provide a novel means to ...
Promoting the sexual health of people living with severe mental illness
(2020-08)
Sexual health is an important part of an individual’s overall health profile. However, for people with a severe mental illness (SMI), maintaining optimal sexual health can be a challenge. Mental health nurses have an ...
The service user experience of SlowMo therapy: A co-produced thematic analysis of service users' subjective experience
(2022-04)
Objectives: SlowMo is the first blended digital therapy for paranoia, showing significant small-moderate reductions in paranoia in a recent large-scale randomized controlled trial (RCT). This study explored the subjective ...
Body image concerns in patients with persecutory delusions
(2022-04)
Background: Persecutory fears build on feelings of vulnerability that arise from negative views of the self. Body image concerns have the potential to be a powerful driver of feelings of vulnerability. Body image concerns ...
Appraisal of patient-level health economic models of severe mental illness: systematic review
(2021-08)
Healthcare decision makers require accurate long-term economic models to evaluate the cost-effectiveness of new mental health interventions.
Aims
To assess the suitability of current patient-level economic models to ...