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Neurocognitive processes in d-cycloserine augmented single-session exposure therapy for anxiety: A randomized placebo-controlled trial
(2020-06)
Drugs targeting N-methyl-d-aspartate (NMDA) receptors and the ability to learn new associations have been proposed as adjunct treatments to boost the success of exposure therapy for anxiety disorders. However, the effects ...
Neural effects of a single dose of fluoxetine on resting-state functional connectivity in adolescent depression
(2020-11)
Fluoxetine is commonly prescribed in adolescent depression, but the neural mechanisms underlying its action remain poorly understood. Here, we used resting-state functional magnetic resonance imaging to investigate the ...
Precision biomarkers for mood disorders based on brain imaging
(2020-10)
Mood disorders are a global public health problem because of their high prevalence, chronicity, and recurrence throughout the lifespan as well as increased risk of mortality.123 They also impose a heavy economic burden on ...
Glucocorticoid ultradian rhythmicity differentially regulates mood and resting state networks in the human brain: A randomised controlled clinical trial
(2021-02)
Adrenal glucocorticoid secretion into the systematic circulation is characterised by a complex rhythm, composed of the diurnal variation, formed by changes in pulse amplitude of an underlying ultradian rhythm of short ...
Lithium modulates striatal reward anticipation and prediction error coding in healthy volunteers
(2020-10)
Lithium is one of the most effective mood-stabilizing medications in bipolar disorder. This study was designed to test whether lithium administration may stabilize mood via effects on reward processing. It was hypothesized ...
A Dissociation of the Acute Effects of Bupropion on Positive Emotional Processing and Reward Processing in Healthy Volunteers
(2018-10)
Background: Previous research indicates that antidepressants can restore the balance between negative and positive emotional processing early in treatment, indicating a role of this effect in later mood improvement. However, ...
Effect of acute citalopram on self-referential emotional processing and social cognition in healthy volunteers
(2020-10)
Background
Depression is characterised by negative views of the self.
Antidepressant treatment may remediate negative self-schema
through increasing processing of positive information about the
self. Changes in affective ...
Predicting Treatment Response to Antidepressant Medication Using Early Changes in Emotional Processing.
(2019-01)
Antidepressants must be taken for weeks before response can be assessed with many patients not responding to the first medication prescribed. This often results in long delays before effective treatment is started. ...
Effect of Prefrontal Cortex Stimulation on Regulation of Amygdala Response to Threat in Individuals With Trait Anxiety A Randomized Clinical Trial
(2019-01)
Importance Transcranial direct current stimulation (tDCS) of the dorsolateral prefrontal cortex (DLPFC) is under clinical investigation as a treatment for major depressive disorder. However, the mechanisms of action are ...
A single dose of fluoxetine reduces neural limbic responses to anger in depressed adolescents
(2019-01-21)
Depression in adolescence is frequently characterised by symptoms of irritability. Fluoxetine is the antidepressant with
the most favourable benefit:risk ratio profile to treat adolescent depression, but the neural ...