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    Neural effects of a single dose of fluoxetine on resting-state functional connectivity in adolescent depression

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    Date
    2020-11
    Author
    Capitao, Liliana
    Chapman, Robert
    Wright, Lucy C
    Murphy, Susannah E
    James, Anthony
    Cowen, Philip J
    Harmer, Catherine J
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    Citation
    Liliana P Capitão, Robert Chapman, Nicola Filippini, Lucy Wright, Susannah E Murphy, Anthony James, Phil J Cowen, Catherine J Harmer. Neural effects of a single dose of fluoxetine on resting-state functional connectivity in adolescent depression. 2020 Journal of Psychopharmacology 1–5
    Abstract
    Fluoxetine is commonly prescribed in adolescent depression, but the neural mechanisms underlying its action remain poorly understood. Here, we used resting-state functional magnetic resonance imaging to investigate the effects of a single dose of fluoxetine vs. placebo in adolescents with major depressive disorder. In contrast with previous studies in adults that have demonstrated an acute effect of antidepressants on activity within the default mode network, a single dose of fluoxetine did not alter activity in this network in adolescent depression. There were unexpected group activity differences in the motor network, which should be clarified in future research.
    Description
    https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
    URI
    https://oxfordhealth-nhs.archive.knowledgearc.net/handle/123456789/629
    Published online at:
    https://doi.org/10.1177/0269881120959608
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