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Now showing items 51-60 of 151
The Acceptability of a Smartphone App (BlueIce) for University Students Who Self-harm
(2022-01)
University students are twice as likely to self-harm than community controls but, unfortunately, help-seeking among this population is particularly low. Given the stigma around self-harm, the face-to-face nature of traditional ...
Pramipexole Enhances Reward Learning by Preserving Value Estimates
(2022-01)
Background: Dopamine D2-like receptor agonists show promise as treatments for depression. They are
thought to act by altering how individuals learn from rewarding experiences. However, the nature of these
reward learning ...
Dose–effect meta-analysis for psychopharmacological interventions using randomised data
(2022-01)
Objective The current practice in meta-analysis of the effects of psychopharmacological interventions ignors the administered dose or restricts the analysis in a dose range. This may introduce unnecessary uncertainty and ...
Anticipating PTSD in severe COVID survivors: the case for screen-and-treat
(2022-01)
Based on research from previous pandemics, studies of critical care survivors, and emerging COVID19 data, we estimate that up to 30% of survivors of severe COVID will develop PTSD. PTSD is
frequently undetected across ...
Selective publication of antidepressant trials and its influence on apparent efficacy: Updated comparisons and meta-analyses of newer versus older trials
(2022-01)
Valid assessment of drug efficacy and safety requires an evidence base free of reporting bias. Using trial reports in Food and Drug Administration (FDA) drug approval packages as a gold standard, we previously found that ...
SlowMo therapy, a new digital blended therapy for fear of harm from others: An account of therapy personalisation within a targeted intervention
(2022-01)
Objectives: SlowMo therapy is a pioneering blended digital
therapy for paranoia, augmenting face-to-face therapy with
an interactive ‘webapp’ and a mobile app. A recent largescale trial demonstrated small–moderate effects ...
Life problems in children and adolescents who self-harm: findings from the multicentre study of self-harm in England
(2022-01)
Background: Self-harm, a significant and increasing global problem in children and adolescents, is often repeated and is associated with risk of future suicide. To identify potential interventions, we need to understand ...
Exploring the factors that influence stakeholders’ expectations and subsequent perception of lower limb orthopaedic surgical outcomes for ambulant children with cerebral palsy – a qualitative study
(2022-01)
Purpose: To explore the perspectives of children with CP, their parents or carers, and health professionals
on factors affecting expectations and perceptions of surgical outcomes for lower limb orthopaedic surgery.
Materials ...
Early- and subsequent- response of cognitive functioning in Alzheimer's disease: Individual-participant data from five pivotal randomized clinical trials of donepezil
(2022-02)
The association between early improvement and subsequent change in cognition is unexamined in antidementia clinical trials. We aimed to examine the consequences of early-response to antidementia medication in Alzheimer's ...
The importance of prototype similarity for physical activity: Cross-sectional and longitudinal associations in a large sample of young adolescents
(2022-02)
Objectives. Physical activity declines during adolescence. The Theory of Planned
Behaviour (TPB) is a useful framework for investigating activity but leaves variance
unexplained. We explored the utility of a dual-process ...