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Polyunsaturated fatty acids metabolism, purine metabolism and inosine as potential independent diagnostic biomarkers for major depressive disorder in children and adolescents
(2018-04-20)
Major depressive disorder (MDD) in children and adolescents is a recurrent and disabling condition globally but its
pathophysiology remains poorly elucidated and there are limited effective treatments available. We performed ...
Sleep Disorders in Early Psychosis: Incidence, Severity, and Association With Clinical Symptoms
(2018-09-08)
Sleep disturbance is known to be associated with psychosis, but sleep disorders (eg. insomnia, nightmare disorder, sleep apnea) have rarely been investigated. We aimed to provide the first detailed assessment of sleep ...
A signature-based machine learning model for distinguishing bipolar disorder and borderline personality disorder
(2018)
Mobile technologies offer new opportunities for prospective, high resolution monitoring of long-term health
conditions. The opportunities seem of particular promise in psychiatry where diagnoses often rely on retrospective
and ...
Self-Harm, Suicidal Behaviours, and Cyberbullying in Children and Young People: Systematic Review
(2018-04)
Background: Given the concerns about bullying via electronic communication in children and young people and its possible contribution to self-harm, we have reviewed the evidence for associations between cyberbullying ...
Absent sleep EEG spindle activity in GluA1 (Gria1) knockout mice: relevance to neuropsychiatric disorders
(2018-08)
Sleep EEG spindles have been implicated in attention, sensory processing, synaptic plasticity and memory consolidation. In humans, deficits in sleep spindles have been reported in a wide range of neurological and psychiatric ...
A systematic review of co-responder models of police mental health ‘street’ triage
(2018-08)
Background:
Police mental health street triage is an increasingly common intervention when dealing with police incidents in which there is a suspected mental health component. We conducted a systematic review of street ...
Clients' experience of change: an exploration of the influence of reformulation tools in Cognitive Analytic Therapy
(2018-10-10)
Case formulation is considered important in both the development of the therapeutic relationship and in starting the process of therapeutic change. Cognitive analytic therapy describes the developmental origins and maintenance ...
Comparative efficacy and tolerability of medications for attention-deficit hyperactivity disorder in children, adolescents, and adults: a systematic review and network meta-analysis
(2018-08)
The benefits and safety of medications for attention-deficit hyperactivity disorder (ADHD) remain controversial, and guidelines are inconsistent on which medications are preferred across different age groups. We aimed to ...
Lighthouse Parenting Programme: Description and pilot evaluation of Mentalization-Based Treatment (MBT) to address child maltreatment.
(2018)
This paper introduces an innovative Mentalization - Based Treatment (MBT) parenting intervention for families where children are at risk of maltreatment. The Lighthouse MBT Parenting Programme aims to prevent child ...
Adapted CBT to Stabilize Sleep on Psychiatric Wards: a Transdiagnostic Treatment Approach
(2018-04-04)
Background: Almost all patients admitted at acute crisis to a psychiatric ward experience clinically significant symptoms of insomnia. Ward environments pose challenges to both sleep and the delivery of therapy. Despite ...