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Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis
(2018-04)
BACKGROUND Major depressive disorder is one of the most common, burdensome, and costly psychiatric disorders worldwide in adults. Pharmacological and non-pharmacological treatments are available; however, because of ...
Network meta-analysis of antidepressants – Authors' reply
(2018-09-22)
Comments on issues raised with Cipriani et al, 'Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis' ...
Different Types and Acceptability of Psychotherapies for Acute Anxiety Disorders in Children and Adolescents: A Network Meta-analysis
(2018-10)
Anxiety disorders are common in children and adolescents, and uncertainty
remains regarding the optimal strategy of psychotherapies in this population.
OBJECTIVE: To compare and rank the different types of psychotherapies ...
Modelling suicide in bipolar disorders: Limitations and opportunities
(2018-07)
Commentary on: Malhi GS, Outhred T, Das P et al. Modeling suicide in bipolar disorders. Bipolar Disord. 2018. In their paper in this issue, Malhi et al highlight a key clinical area; whilst suicide rates are increased in ...
Efficacy and Acceptability of Interventions for Attenuated Positive Psychotic Symptoms in Individuals at Clinical High Risk of Psychosis: A Network Meta-Analysis
(2018-06-12)
Background: Attenuated positive psychotic symptoms represent the defining features of the clinical high-risk for psychosis (CHR-P) criteria. The effectiveness of each available treatment for reducing attenuated positive ...
Polyunsaturated fatty acids metabolism, purine metabolism and inosine as potential independent diagnostic biomarkers for major depressive disorder in children and adolescents
(2018-04-20)
Major depressive disorder (MDD) in children and adolescents is a recurrent and disabling condition globally but its
pathophysiology remains poorly elucidated and there are limited effective treatments available. We performed ...
Comparative efficacy and tolerability of medications for attention-deficit hyperactivity disorder in children, adolescents, and adults: a systematic review and network meta-analysis
(2018-08)
The benefits and safety of medications for attention-deficit hyperactivity disorder (ADHD) remain controversial, and guidelines are inconsistent on which medications are preferred across different age groups. We aimed to ...
Antidepressants might work for people with major depression: where do we go from here? (Comment)
(2018-06)
The publication of our updated network meta-analysis about antidepressants for the acute treatment of major depression has generated a wide discussion in newspapers, social media, and scientific journals. Based on 522 ...
3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy for post-traumatic stress disorder in service personnel
(2018-06)
Comment: This current study describes the therapeutic use of MDMA by committed experts in a specialised setting in a small group of participants, most of whom self-referred for the trial. The unmet need for better PTSD ...
Is placebo response in antidepressant trials rising or not? A reanalysis of datasets to conclude this long-lasting controversy
(2018-01)
It had long been believed that placebo response rates in antidepressant trials have been increasing and that they were responsible for rising numbers of so-called failed antidepressant trials. Two recent systematic reviews ...