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Now showing items 121-130 of 151
Effects of escitalopram therapy on functional brain controllability in major depressive disorder
(2022-04)
Antidepressant drugs are the mainstay of treatment for patients with major depressive disorders (MDD). Given the critical role of the underlying neural control mechanism in the physiopathology of depression, this study ...
Mortality in psychotic depression: 18-year follow-up study
(2022-10)
Background
Evidence on the role of co-occurring psychiatric disorders in mortality associated with psychotic depression is limited.
Aims
To estimate the risk of cause-specific mortality in psychotic depression compared ...
Pragmatic Randomised Controlled Trial of Guided Self-help Versus Individual Cognitive Behavioural Therapy with a Trauma Focus for Post-Traumatic Stress Disorder (RAPID)
(2022-10)
Post-traumatic stress disorder (PTSD) is a common, disabling condition that can occur
following major traumatic events. Typical symptoms include distressing reliving, avoidance
of reminders, and feeling a current sense ...
The Power Threat Meaning Framework and the Climate and Ecological Crises
(2022-09)
Climate change poses an existential threat to today’s and future generations. Within this context, important debates are taking place about the risk of individualising and de-contextualising both climate-related distress ...
What is Computational Psychiatry Good For?
(2022-09)
It is rare in the field of biological psychiatry for hypotheses to be definitively refuted. Rather, topics
of investigation drift into and out of fashion, often driven by the initial excitement of technological
innovation, ...
CACNA1C (CaV1.2) and other L-type calcium channels in the pathophysiology and treatment of psychiatric disorders: Advances from functional genomics and pharmacoepidemiology
(2022-09)
A role for voltage-gated calcium channels (VGCCs) in psychiatric disorders has long been postulated as part of a broader involvement of intracellular calcium signalling. However, the data were inconclusive and hard to ...
Examining the Effectiveness of Web-Based Interventions to Enhance Resilience in Health Care Professionals: Systematic Review
(2022-07)
Background: Internationally, the impact of continued exposure to workplace environmental and psychological stressors on
health care professionals’mental health is associated with increased depression, substance misuse, ...
The serum metabolomic profile of a distinct, inflammatory subtype of acute psychosis
(2022-09)
A range of studies suggest that a proportion of psychosis may have an autoimmune basis, but this has not translated through into clinical practice—there is no biochemical test able to accurately identify psychosis resulting ...
Identifying psychiatric diagnosis from missing mood data through the use of log-signature features
(2022-11)
The availability of mobile technologies has enabled the efficient collection of prospective longitudinal, ecologically valid self-reported clinical questionnaires from people with psychiatric diagnoses. These data streams ...
What do others think? The why, when and how of using surveys in CBT
(2022-09)
Surveys are a powerful technique in cognitive behavioural therapy (CBT). A form of behavioural experiment, surveys can be used to test beliefs, normalise symptoms and experiences, and generate compassionate perspectives. ...