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Understanding, treating, and renaming grandiosedelusions: A qualitative study
(2019-11)
Background.Grandiose delusions are arguably the most neglected psychotic experience in research.
Objectives.We aimed to discover from patients: whether grandiose delusions have harmful consequences; the psychological ...
The comments of voices on the appearance of patients with psychosis: ‘the voices tell me that I am ugly’
(2019-09)
Background:There are high rates of obesity and low self-esteem in patients with psychosis. The occurrence of negative voice content directly about appearance is therefore plausible. Derogatory comments about appearance are ...
Suicidal ideation and behaviour in patients with persecutory delusions: Prevalence, symptom associations, and psychological correlates
(2019-07)
Background:To determine the prevalence of suicidal ideation and behaviour - and their correlates - in patients with persecutory delusions.
Methods:110 patients with persecutory delusions in the context of non-affective ...
Clozapine-induced pericarditis: an ethical dilemma
(2019-06)
Clozapine is an atypical antipsychotic used most frequently in the management of treatment-resistant schizophrenia, where severely unwell patients have failed to respond to standard antipsychotic therapy. Clozapine is ...
Prevalence of Non-Affective Psychoses in Individuals with Autism Spectrum Disorders: A Systematic Review
(2019-08)
Autism spectrum disorders (ASD) and non-affective psychoses such as schizophrenia are commonly acknowledged as discrete entities. Previous research has revealed evidence of high comorbidity between these conditions, but ...
Cognitive Behavioural Therapies for Psychosis
(2019-10)
Cognitive Behavioural Therapy for psychosis (CBTp) is a recommended treatment in several international guidelines for schizophrenia and psychosis. CBTp is an adaptation of traditional cognitive behavioural therapy for ...
The effect of a genetic variant at the schizophrenia associated AS3MT/BORCS7 locus on striatal dopamine function: A PET imaging study
(2019)
One of the most statistically significant loci to result from large-scale GWAS of schizophrenia is 10q24.32. However, it is still unclear how this locus is involved in the pathoaetiology of schizophrenia. The hypothesis ...
Comparative effects of 18 antipsychotics on metabolic function in schizophrenia, predictors of metabolic dysregulation, and association with psychopathology: a systematic review and network meta-analysis
(2019-10)
Background: Antipsychotic-treatment is associated with metabolic disturbance. However, the relative degree to which metabolic alterations occur in treatment with different antipsychotics remains unclear. Furthermore, ...
Hummingbird Study: a study protocol for a multicentre exploratory trial to assess the acceptance and performance of a digital medicine system in adults with schizophrenia, schizoaffective disorder or first-episode psychosis
(2019-06)
Introduction: In patients with schizophrenia, medication adherence is important for relapse prevention, and effective adherence monitoring is essential for treatment planning. A digital medicine system (DMS) has been ...
The side effect profile of Clozapine in real world data of three large mental hospitals
(2020-01)
Objective: Mining the data contained within Electronic Health Records (EHRs) can potentially generate a greater understanding of medication effects in the real world, complementing what we know from Randomised control ...