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Attentional bias modification is associated with fMRI response toward negative stimuli in individuals with residual depression: a randomized controlled trial
(2019-08)
BACKGROUND:Attentional bias modification (ABM) may lead to more adaptive emotion perception and emotion regulation. Understanding the neural basis of these effects may lead to greater precision for the development of future ...
How representative are neuroimaging samples? Large-scale evidence for trait anxiety differences between MRI and behaviour-only research participants.
(2020-04)
Over the past three decades, MRI has become a key tool to study how cognitive processes are implemented in the human brain. However, the question of whether participants recruited into MRI studies differ from participants ...
Neurocognitive processes in d-cycloserine augmented single-session exposure therapy for anxiety: A randomized placebo-controlled trial
(2020-06)
Drugs targeting N-methyl-d-aspartate (NMDA) receptors and the ability to learn new associations have been proposed as adjunct treatments to boost the success of exposure therapy for anxiety disorders. However, the effects ...
Lithium modulates striatal reward anticipation and prediction error coding in healthy volunteers
(2020-10)
Lithium is one of the most effective mood-stabilizing medications in bipolar disorder. This study was designed to test whether lithium administration may stabilize mood via effects on reward processing. It was hypothesized ...
A Dissociation of the Acute Effects of Bupropion on Positive Emotional Processing and Reward Processing in Healthy Volunteers
(2018-10)
Background: Previous research indicates that antidepressants can restore the balance between negative and positive emotional processing early in treatment, indicating a role of this effect in later mood improvement. However, ...
Using Computational Psychiatry to Rule Out the Hidden Causes of Depression
(2017-08)
In an ideal world, our understanding of the causes of psychiatric disorders would progress by testing mechanistic hypotheses in experimental studies, using the results of these studies to identify situations in which the ...
Predicting Treatment Response to Antidepressant Medication Using Early Changes in Emotional Processing.
(2019-01)
Antidepressants must be taken for weeks before response can be assessed with many patients not responding to the first medication prescribed. This often results in long delays before effective treatment is started. ...
Effect of Prefrontal Cortex Stimulation on Regulation of Amygdala Response to Threat in Individuals With Trait Anxiety A Randomized Clinical Trial
(2019-01)
Importance Transcranial direct current stimulation (tDCS) of the dorsolateral prefrontal cortex (DLPFC) is under clinical investigation as a treatment for major depressive disorder. However, the mechanisms of action are ...
Symptom trajectories in discontinuation trials.
(2017-02)
Many patients with clinical depression, particularly those with recurrent illness, are treated with maintenance antidepressants after an acute-phase response. But how effective is this approach? The effectiveness of ...
Affective bias as a rational response to the statistics of rewards and punishments
(2017-10)
Affective bias, the tendency to differentially prioritise the processing of negative relative to positive events, is commonly observed in clinical and non-clinical populations. However, why such biases develop is not known. ...