• Login
    View Item 
    •   ORKA Home
    • Conditions, Lifestyle Factors & Interventions
    • Conditions
    • Musculoskeletal Diseases
    • View Item
    •   ORKA Home
    • Conditions, Lifestyle Factors & Interventions
    • Conditions
    • Musculoskeletal Diseases
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Relationship between Cardiopulmonary, Mitochondrial and Autonomic Nervous System Function Improvement after an Individualised Activity Programme upon Chronic Fatigue Syndrome Patients

    Thumbnail
    View/Open
    Main article (2.031Mb)
    Date
    2021-04
    Author
    Dawes, Helen
    Metadata
    Show full item record
    Citation
    Sławomir Kujawski,†OrcID,Jo Cossington ,Joanna Słomko,Monika Zawadka-Kunikowska ,Małgorzata Tafil-Klawe ,Jacek J. Klawe ,Katarzyna Buszko , Jakovljevic ,Mariusz Kozakiewicz ,Karl J. Morten ,Helen Dawes ,James W. L. Strong ,Modra Murovska,Jessica Van Oosterwijck,Fernando Estevez-Lopez ,Julia L. Newton,Lynette Hodges ,Paweł Zalewski . Relationship between Cardiopulmonary, Mitochondrial and Autonomic Nervous System Function Improvement after an Individualised Activity Programme upon Chronic Fatigue Syndrome Patients. J. Clin. Med. 2021, 10(7), 1542
    Abstract
    Background: The therapeutic effects of exercise from structured activity programmes have recently been questioned; as a result, this study examines the impact of an Individualised Activity Program (IAP) on the relationship with cardiovascular, mitochondrial and fatigue parameters. Methods: Chronic fatigue syndrome (CFS) patients were assessed using Chalder Fatigue Questionnaire (CFQ), Fatigue Severity Score (FSS) and the Fatigue Impact Scale (FIS). VO2peak, VO2submax and heart rate (HR) were assessed using cardiopulmonary exercise testing. Mfn1 and Mfn2 levels in plasma were assessed. A Task Force Monitor was used to assess ANS functioning in supine rest and in response to the Head-Up Tilt Test (HUTT). Results: Thirty-four patients completed 16 weeks of the IAP. The CFQ, FSS and FIS scores decreased significantly along with a significant increase in Mfn1 and Mfn2 levels (p = 0.002 and p = 0.00005, respectively). The relationships between VO2 peak and Mfn1 increase in response to IAP (p = 0.03) and between VO2 at anaerobic threshold and ANS response to the HUTT (p = 0.03) were noted. Conclusions: It is concluded that IAP reduces fatigue and improves functional performance along with changes in autonomic and mitochondrial function. However, caution must be applied as exercise was not well tolerated by 51% of patients.
    Description
    This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
    URI
    https://oxfordhealth-nhs.archive.knowledgearc.net/handle/123456789/837
    Published online at:
    https://doi.org/10.3390/jcm10071542
    Collections
    • Musculoskeletal Diseases [23]

    Oxford Health copyright © 2019
    Contact Us | Send Feedback | JSPUI
    Powered by KnowledgeArc
     

     

    Browse

    All of ORKACommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsContributor DisciplineThis CollectionBy Issue DateAuthorsTitlesSubjectsContributor Discipline

    My Account

    Login

    Researcher Profiles

    Researchers

    Oxford Health copyright © 2019
    Contact Us | Send Feedback | JSPUI
    Powered by KnowledgeArc