Conditions: Recent submissions
Now showing items 461-480 of 698
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Technology Matters: BlueIce – using a smartphone app to beat adolescent self‐harm
(2020-06)Despite the recent proliferation of mental health apps, few have directly focused on the prevention of self-harm. The available apps are described and the limited, although encouraging, outcome data are summarised. The ... -
Neurophysiological signatures of hand motor response to dual-transcranial direct current stimulation in subacute stroke: a TMS and MEG study
(2020-06)Background:Dual transcranial direct current stimulation (tDCS) to the bilateral primary motor cortices (M1s) has potential benefits in chronic stroke, but its effects in subacute stroke, when behavioural effects might be ... -
Fear of illness recurrence and mental healthanxiety in people recovering from psychosis andcommon mental health problems
(2020-06)Objectives: It is well known that mental health problems can recur even after effective treatment, leading to an understandable fear of illness recurrence (FIR) and mental health anxiety (MHA). These may themselves contribute ... -
Living with persistent insomnia after cancer: Aqualitative analysis of impact and management
(2020-06)Objectives.To conduct a qualitative exploration of the lived experience of insomniadisorder and its management amongst a sample of mixed-diagnoses cancer survivors.Methods.Twenty-seven cancer survivors with persistent ... -
Comparative efficacy and acceptability of antidepressants, psychotherapies, and their combination for acute treatment of children and adolescents with depressive disorder: a systematic review and network meta-analysis
(2020-07)Depressive disorders are common in children and adolescents. Antidepressants, psychotherapies, and their combination are often used in routine clinical practice; however, available evidence on the comparative efficacy and ... -
Sleep disturbance and psychiatric disorders
(2020-07)Signs of mental ill health that cut across psychiatric diagnostic categories at high rates are typically viewed as non-specific occurrences, downgraded in importance and disregarded. However, problems not associated with ... -
Short-term memory advantage for brief durations in human APOE ε4 carriers
(2020-06)The Apolipoprotein-E (APOE) ε4 gene allele, the highest known genetic risk factor for Alzheimer’s disease, has paradoxically been well preserved in the human population. One possible explanation offered by evolutionary ... -
Are PROMs just for patients? Piloting the Long-Term Conditions Questionnaire for use with patients and carers in memory clinic settings
(2020-05)Background & Aims The Long-Term Conditions Questionnaire (LTCQ) was developed for assessing the overall impact of long-term health conditions (LTCs) on quality of life. Enhancing quality of life for people affected by ... -
Hemizygous mutations in L1CAM in two unrelated male probands with childhood onset psychosis
(2020-06)Objective :To identify genes underlying childhood onset psychosis. Methods :Patients with onset of psychosis at age 13 or younger were identified from clinics across England, and they and their parents were exome sequenced ... -
Mortality in children and adolescents who present to hospital following non-fatal self-harm: an observational cohort study based on the Multicentre Study of Self-harm in England
(2020-02)Background Self-harm and suicide in children and adolescents are both growing problems, with self-harm associated with a significant risk of subsequent death, particularly suicide. Long-term follow-up studies are necessary ... -
Real-world effect of antidepressants for depressive disorder in primary care: protocol of a population-based cohort study
(2020-06)Introduction Clinical guidelines recommend antidepressants as the first line of treatment for adults with moderate-to-severe depression. Randomised trials provide the best evidence on the comparative effectiveness of ... -
Advances in the computational understanding of mental illness
(2020-07)Computational psychiatry is a rapidly growing field attempting to translate advances in computational neuroscience and machine learning into improved outcomes for patients suffering from mental illness. It encompasses both ... -
Making Mesothelioma Patient Research Happen: The United Kingdom Experience
(2020-06)In just a few years, the collaboration between an expert team of nurses, a charity committed to patients, the NHS, and successful health academics has resulted in an excellent, clinically relevant portfolio of research. ... -
Outcome domains and measures after lower limb orthopaedic surgery for ambulant children with cerebral palsy: an updated scoping review
(2020-06)Aim: To determine the reported outcome domains and measures used to assess lower limb orthopaedic surgery of ambulant children and young people with cerebral palsy (CP) and map these outcomes to the International Classification ... -
The effects of small-needle-knife therapy on pain and mobility from knee osteoarthritis: a pilot randomized-controlled study
(2020-06)Objective:To investigate the effect of small needle-knife therapy in people with painful knee osteoarthritis. Design:Pilot randomised, controlled trial. Setting:Rehabilitation hospital. Subjects:In-patients with ... -
Dissociating Spatial Attention from Neglect Dyslexia: a Single Case Study
(2020-06)Word-centred neglect dyslexia is generally thought to be caused by a visuospatial neglect-like attentional deficit which impacts orientation-canonical representations of visual stimuli. However, the relationship between ... -
Patient fibroblast circadian rhythms predict lithium sensitivity in bipolar disorder
(2020-05)Bipolar disorder is a chronic neuropsychiatric condition associated with mood instability, where patients present significant sleep and circadian rhythm abnormalities. Currently, the pathophysiology of bipolar disorder ... -
Virtual reality clinical-experimental tests of compassion treatment techniques to reduce paranoia
(2020-05)Paranoia may build on negative beliefs held both about the self and others. Compassionate imagery may be one way of reducing such negative beliefs, and hence paranoia. Two studies tested this idea, one targeting compassion ... -
Pharmacological Augmentation in Unipolar Depression: A Guide to the Guidelines
(2020-05)Background: Pharmacological augmentation is a recommended strategy for patients with treatment-resistant depression. A range of guidelines provide advice on treatment selection, prescription, monitoring and discontinuation, ... -
Childhood determinants of past-year anxiety and depression in recently transitioned military personnel
(2020-05)Background: Anxiety and depression may hamper a smooth transition from military to civilian life and may be important predictors of longer-term health and functioning. However, it is as yet unclear to what extent they are ...