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Cost and quality-of-life impacts of community treatment orders (CTOs) for patients with psychosis: economic evaluation of the OCTET trial
(2020-07)
Purpose:Current RCT and meta-analyses have not found any effect of community treatment orders (CTOs) on hospital or social outcomes. Assumed positive impacts of CTOs on quality-of-life outcomes and reduced hospital costs ...
Multisite randomised controlled trial of trauma-focused cognitive behaviour therapy for psychosis to reduce post-traumatic stress symptoms in people with co-morbid post-traumatic stress disorder and psychosis, compared to treatment as usual: study protocol for the STAR (Study of Trauma And Recovery) trial
(2022-05)
People with psychosis have high rates of trauma, with a post-traumatic stress disorder (PTSD) prevalence rate of approximately 15%, which exacerbates psychotic symptoms such as delusions and hallucinations. Pilot studies ...
New drug targets in psychiatry: Neurobiological considerations in the genomics era
(2022-07)
After a period of withdrawal, pharmaceutical companies have begun to reinvest in neuropsychiatric disorders, due to improvements in our understanding of these disorders, stimulated in part by genomic studies. However, ...
A family perspective on parental psychosis: An interpretative phenomenological analysis study
(2022-11)
Objectives: While one third of people with a psychotic
disorder are a parent, there has been little research to date
examining the consequences of this from a whole family
perspective. This study investigates families ...
The Needs and Experiences of Parents with Psychosis: A Qualitative Interview Study
(2022-09)
Over a third of individuals diagnosed with a psychotic disorder are also a parent. The symptoms of psychosis and side effects of antipsychotic medication can impact on parents’ awareness of the needs of their children and, ...
Measuring dissociation across adolescence and adulthood: Developing the short-form Cernis Felt Sense of Anomaly scale (CEFSA-14)
(2023-05)
Dissociation may be important across many mental health disorders, but has been variously
conceptualised and measured. We introduced a conceptualisation of a common type of dissociative
experience, ‘felt sense of anomaly’ ...
Neuroimaging glutamatergic mechanisms differentiating antipsychotic treatment-response
(2023-06)
Glutamatergic dysfunction is associated with failure to respond to antipsychotic medication in individuals with schizophrenia. Our objective was to combine neurochemical and functional brain imaging methods to investigate ...
Development and initial evaluation of a behavioural intervention to support weight management for people with serious mental illness: an uncontrolled feasibility and acceptability study
(2023-03)
The rates of obesity and associated health problems are higher in people with serious mental illness (SMI), such as schizophrenia and bipolar disorder, than the general population. A primary care referral to a behavioural ...
Hippocampal Glutamate, Resting Perfusion and the Effects of Cannabidiol in Psychosis Risk
(2023-03)
Background: Preclinical and human data suggest that the onset of psychosis involves
hippocampal glutamatergic dysfunction, driving hyperactivity/hyperperfusion in a
hippocampal-midbrain-striatal circuit. Whether glutamatergic ...
Paediatric traumatic brain injury as a risk factor for psychosis and psychotic symptoms: a systematic review and meta-analysis
(2023-02)
Psychosis is one of the most disabling psychiatric disorders. Paediatric traumatic brain injury (pTBI) has been cited as a developmental risk factor for psychosis, however this association has never been assessed ...