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Ketamine treatment for depression: qualitative study exploring patient views
(2021-01)
Ketamine is a new and promising treatment for depression but comes with challenges to implement because of its potential for abuse.
Aims
We sought the views of patients to inform policy and practical decisions about ...
Mood Homeostasis, Low Mood, and History of Depression in 2 Large Population Samples
(2020-04)
Importance Existing therapeutic options are insufficient to tackle the disease burden of depression, and new treatments are sorely needed. Defining new psychotherapeutic targets is challenging given the paucity of coherent ...
Antidepressants plus benzodiazepines in major depressive disorder: a clinical dilemma with no recent answers from research
(2020-10)
Comorbid anxiety symptoms are common in depression, and adding benzodiazepines to antidepressant treatment may seem a rational clinical solution. Benzodiazepines also have potential to reduce the initial anxiety that may ...
Vortioxetine for depression: the evidence for its current use in the UK: COMMENTARY ON… COCHRANE CORNER
(2018-12-17)
The pharmacological treatment of depression is often hampered by side-effects and unsatisfactory response to treatment. Vortioxetine is one of the newest antidepressants on the market, purportedly with a different mechanism ...
How effective is augmentation with psychotherapy as a next-step option for treatment-resistant depression?
(2020-08)
Determining the optimum next-step treatment for the numerous patients with depression who do not adequately respond to an initial trial of medication remains a source of uncertainty in clinical practice. Although a number ...
Affective bias as a rational response to the statistics of rewards and punishments
(2017-10)
Affective bias, the tendency to differentially prioritise the processing of negative relative to positive events, is commonly observed in clinical and non-clinical populations. However, why such biases develop is not known. ...
A dose-effect network meta-analysis model: an application in antidepressants
(2021-04)
Network meta-analysis (NMA) has been used to answer a range of clinical questions about the preferable intervention for a given condition. Although the effectiveness and safety of pharmacological agents depend on the dose ...
Negative bias in interpretation and facial expression recognition in late life depression: A case control study.
(2021-04)
While cognitive bias in younger adults with depression has been extensively researched, there have been relatively few investigations of the presence of cognitive bias in late life depression (LLD). This exploratory study ...
Insomnia as a mediating therapeutic target for depressive symptoms: A sub-analysis of participant data from two large randomized controlled trials of a digital sleep intervention
(2020-06)
Insomnia predicts the onset of depression, commonly co-presents with depression
and often persists following depression remission. However, these conditions can
be challenging to treat concurrently using depression-specific ...
A retrospective examination of care pathways in individuals with treatment-resistant depression
(2021-05)
Individuals with treatment-resistant depression (TRD) experience a high burden of illness. Current guidelines recommend a stepped care approach for treating depression, but the extent to which best-practice care pathways ...