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Now showing items 21-30 of 44
One step closer to personalised prescribing of antidepressants: using real-world data together with patients and clinicians' preferences
(2019-07)
Antidepressants for many decades have been shown to be an effective treatment for depressive disorder.1 Approximately 80% of people with depressive disorder in the UK will have been prescribed an antidepressant within the ...
The effects of intramuscular administration of scopolamine augmentation in moderate to severe major depressive disorder: a randomized, double-blind, placebo-controlled trial
(2020-07)
Introduction:Major depressive disorder (MDD) is a common affective disorder. Currently established pharmacotherapies lack rapid clinical response, thereby limiting their ability to bring instant relief to patients. A series ...
Vortioxetine for depression: the evidence for its current use in the UK: COMMENTARY ON… COCHRANE CORNER
(2018-12-17)
The pharmacological treatment of depression is often hampered by side-effects and unsatisfactory response to treatment. Vortioxetine is one of the newest antidepressants on the market, purportedly with a different mechanism ...
Characteristics of patients expressing an interest in ketamine treatment: results of an online survey
(2018-04)
Off-label ketamine treatment has shown acute antidepressant effects that offer hope for patients with therapy-resistant depression. However, its potential for integration into treatment algorithms is controversial, not ...
A dose-effect network meta-analysis model: an application in antidepressants
(2021-04)
Network meta-analysis (NMA) has been used to answer a range of clinical questions about the preferable intervention for a given condition. Although the effectiveness and safety of pharmacological agents depend on the dose ...
A continuum hypothesis of psychotomimetic rapid antidepressants
(2021-05)
Ketamine, classical psychedelics and sleep deprivation are associated with rapid effects on depression. Interestingly, these interventions also have common psychotomimetic actions, mirroring aspects of psychosis such as ...
An Experimental Medicine Investigation of the Effects of Subacute Pramipexole Treatment on Emotional Information Processing in Healthy Volunteers
(2021-08)
Treatment with the dopamine D2/D3 receptor agonist pramipexole has demonstrated
promising clinical effects in patients with depression. However, the mechanisms through which
pramipexole might alleviate depressive symptoms ...
An Experimental Medicine Investigation of the Effects of Subacute Pramipexole Treatment on Emotional Information Processing in Healthy Volunteers
(2021-08)
Treatment with the dopamine D2/D3 receptor agonist pramipexole has demonstrated
promising clinical effects in patients with depression. However, the mechanisms through which
pramipexole might alleviate depressive symptoms ...
Statins for major depressive disorder: A systematic review and meta-analysis of randomized controlled trials
(2021-03)
The burden of depressive disorder is large and new treatment approaches are required. Repurposing widely available drugs such as statins may be a time- and cost-effective solution. Statins have anti-inflammatory and ...
No antidepressant-like acute effects of bright light on emotional information processing in healthy volunteers
(2021-11)
Rationale: Bright light treatment (BLT) is an efficacious antidepressant intervention, but its mechanism of action is not well understood. Antidepressant drugs acutely affect how emotional information is processed, pushing ...