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Now showing items 11-14 of 14
Neurons derived from individual early Alzheimer’s disease patients reflect clinical vulnerability
(2021-11)
Modelling sporadic Alzheimer’s disease (sAD) with patient-derived induced pluripotent stem
cells (iPSCs) is challenging yet remains an important step in understanding the disease. Here
we report a novel approach of sAD ...
Early- and subsequent- response of cognitive functioning in Alzheimer's disease: Individual-participant data from five pivotal randomized clinical trials of donepezil
(2022-02)
The association between early improvement and subsequent change in cognition is unexamined in antidementia clinical trials. We aimed to examine the consequences of early-response to antidementia medication in Alzheimer's ...
Identification of Substrate-specific Allosteric Fingerprints in Matrix Metalloprotease-1 on Amyloid-beta Peptide Aggregates and Drug Screening With Single Molecule Insights
(2022-02)
Amyloid-beta peptide (Aβ) is the primary component of water-insoluble extracellular plaques, one of the
critical hallmarks of Alzheimer's disease (AD). Matrix metalloproteases (MMPs) are broad-spectrum
proteases with ...
Adapted problem adaptation therapy for depression in mild to moderate Alzheimer's disease dementia: A randomized controlled trial
(2024-03)
Introduction: Trials of effectiveness of treatment options for depression in dementia are an important priority.
Methods: Randomized controlled trial to assess adapted Problem Adaptation Therapy (PATH) for depression in ...