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Now showing items 121-130 of 158
Insomnia as a mediating therapeutic target for depressive symptoms: A sub-analysis of participant data from two large randomized controlled trials of a digital sleep intervention
(2020-06)
Insomnia predicts the onset of depression, commonly co-presents with depression
and often persists following depression remission. However, these conditions can
be challenging to treat concurrently using depression-specific ...
Health Outcome Prioritization in Alzheimer's Disease: Understanding the Ethical Landscape.
(2020-07)
BACKGROUND:Dementia has been described as the greatest global health challenge in the 21st century on account of longevity gains increasing its incidence, escalating health and social care pressures. These pressures highlight ...
Linking the Mini-Mental State Examination, the Alzheimer’s Disease Assessment Scale–Cognitive Subscale and the Severe Impairment Battery: evidence from individual participant data from five randomised clinical trials of donepezil
(2020-10)
Background The Mini-Mental State Examination (MMSE), the Alzheimer’s Disease Assessment Scale–Cognitive Subscale (ADAS-Cog) and the Severe Impairment Battery (SIB) are widely used rating scales to assess cognition in ...
Short-term memory advantage for brief durations in human APOE ε4 carriers
(2020-06)
The Apolipoprotein-E (APOE) ε4 gene allele, the highest known genetic risk factor for Alzheimer’s disease, has paradoxically been well preserved in the human population. One possible explanation offered by evolutionary ...
The effectiveness of interventions aimed at improving wellbeing and resilience to stress in first responders: A systematic review
(2020-07)
First responders are routinely exposed to traumatic critical incidents, placing them at higher risk for developing stress-related psychopathology and associated health problems than the general population. Interventions ...
Prediction of Discontinuation of Structured Exercise Programme in Chronic Fatigue Syndrome Patients
(2020-10)
The purpose of this study was to assess differences in the physiological profiles of
completers vs. non-completers following a structured exercise programme (SEP) and the ability to
predict non-completers, which is ...
Outcome domains and measures after lower limb orthopaedic surgery for ambulant children with cerebral palsy: an updated scoping review
(2020-06)
Aim: To determine the reported outcome domains and measures used to assess lower limb orthopaedic surgery of ambulant children and young people with cerebral palsy (CP) and map these outcomes to the International Classification ...
Environmental changes to reduce self-harm on an adolescent inpatient psychiatric ward: an interrupted time series analysis
(2020-07)
Existing interventions to reduce self-harm in adolescents admitted to psychiatric wards are usually focused on individual psychological treatments. However, the immediate ward environment in which treatment takes place is ...
An invasive group A streptococcal infection outbreak: a community nursing experience
(2020-07)
Invasive group A streptococcus (iGAS) can cause serious infections. Between January and July 2018, seven patients, living in the same geographical area and receiving district nursing care for wound management, were identified ...
Systematic review of interventions to improve constant observation on adult inpatient psychiatric wards
(2020-02)
Constant observation is frequently conducted on inpatient psychiatric units to manage patients at risk of harming themselves or others. Despite its widespread use, there is little evidence of the efficacy of the practice ...