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A randomised controlled trial of therapist-assisted online psychological therapies for posttraumatic stress disorder (STOP-PTSD): trial protocol
(2020-04)
Background: Over the last few decades, effective psychological treatments for posttraumatic stress disorder (PTSD) have been developed, but many patients are currently unable to access these treatments. There is initial ...
Effect of the NMDA receptor partial agonist, d-cycloserine, on emotional processing and autobiographical memory
(2020-04)
Background: Studies suggest that d-cycloserine (DCS) may have antidepressant potential through its interaction with the glycine site of the N-Methyl-D-aspartate receptor (NMDAR); however clinical evidence of DCS’s efficacy ...
Comparative efficacy and acceptability of antidepressants, psychotherapies, and their combination for acute treatment of children and adolescents with depressive disorder: a systematic review and network meta-analysis
(2020-07)
Depressive disorders are common in children and adolescents. Antidepressants, psychotherapies, and their combination are often used in routine clinical practice; however, available evidence on the comparative efficacy and ...
Antipsychotic medication versus psychological intervention versus a combination of both in adolescents with first-episode psychosis (MAPS): a multicentre, three-arm, randomised controlled pilot and feasibility study
(2020-07)
Background
Evidence for the effectiveness of treatments in early-onset psychosis is sparse. Current guidance for the treatment of early-onset psychosis is mostly extrapolated from trials in adult populations. The UK ...
Effective psychological treatment for PTSD changes the dynamics of specific large-‐scale brain networks
(2020-01)
Very
little
is
known
about
the
role
of
effective
cognitive
therapy
in
reversing
imbalances
in
brain
activity
after
trauma.
We
hypothesised
that
exaggerated
threat
perception
characteristic
of
p ...
Addressing concerns about smoking cessation and mental health: theoretical review and practical guide for healthcare professionals
(2020-07)
Smoking rates in people with depression and anxiety are twice as high as in the general population, even though people with depression and anxiety are motivated to stop smoking. Most healthcare professionals are aware that ...
Developing an automated VR cognitive treatment for psychosis: gameChange VR therapy
(2020-04)
The automated delivery of psychological treatment using virtual reality (VR) has the potential to revolutionise patient access to evidence-based care. VR creates immersive, interactive computer simulations, which elicit ...
Neurocognitive processes in d-cycloserine augmented single-session exposure therapy for anxiety: A randomized placebo-controlled trial
(2020-06)
Drugs targeting N-methyl-d-aspartate (NMDA) receptors and the ability to learn new associations have been proposed as adjunct treatments to boost the success of exposure therapy for anxiety disorders. However, the effects ...
Treating Social Anxiety Disorder Remotely with Cognitive Therapy
(2020-07)
Remote delivery of evidence-based psychological therapies via video conference has become particularly relevant following the COVID-19 pandemic, and is likely to be an on-going method of treatment delivery post-COVID. ...
Behavioural Experiments in Cognitive Therapy for Posttraumatic Stress Disorder: Why, When, and How?
(2020-11)
Behavioural experiments are an integral component of cognitive therapy (CT) for posttraumatic stress disorder (PTSD),
but they can be overlooked due to practical constraints and
therapist concerns. Here we describe why ...