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Adjunctive Psychotherapy for Bipolar Disorder A Systematic Review and Component Network Meta-analysis
(2020-10)
Importance Several psychotherapy protocols have been evaluated as adjuncts to pharmacotherapy for patients with bipolar disorder, but little is known about their comparative effectiveness.
Objective To use systematic ...
Effectiveness of maintenance therapy of lithium vs other mood stabilizers in monotherapy and in combinations: A systematic review of evidence from observational studies
(2018-02)
Objectives: For the first time to present a systematic review of observational studies on the efficiency of lithium
monotherapy in comparison with other maintenance mood stabilizers in monotherapy and in combination.
Methods: ...
A signature-based machine learning model for distinguishing bipolar disorder and borderline personality disorder
(2018)
Mobile technologies offer new opportunities for prospective, high resolution monitoring of long-term health
conditions. The opportunities seem of particular promise in psychiatry where diagnoses often rely on retrospective
and ...
Experiences of remote mood and activity monitoring in bipolar disorder: a qualitative study
(2017-01)
Mobile technology enables high frequency mood monitoring and automated passive collection of date(e.g.actigraphy) from patients more efficiently and less intrusively than has previously been possible. Such techniques are ...
Comparative economic evaluation of quetiapine plus lamotrigine combination vs quetiapine monotherapy (and folic acid vs placebo) in patients with bipolar depression (cequel)
(2018-12)
Although not licensed for acute bipolar depression, lamotrigine has evidence for efficacy in trials and
its use is recommended in guidelines. So far there had been no prospective health economic evaluation of its
use. ...
Effect of lithium on circadian rhythm in bipolar disorder: A systematic review and meta-analysis
(2021-03)
Circadian rhythm disruption is commonly reported in patients with bipolar disorder. Lithium has been suggested to have effects on the circadian clock, the biological basis of the circadian rhythm. The objective of the ...
The costs of bipolar disorder in the United Kingdom
(2021-09)
Objectives: To estimate the individual cost and population-level economic burden of Bipolar Disorder (BD), and explore the impact of clinical and sociodemographic factors on costs in the United Kingdom.
Methods: Annual ...
Study protocol for a randomised placebo-controlled trial of pramipexole in addition to mood stabilisers for patients with treatment resistant bipolar depression (the PAX-BD study)
(2021-07)
Treatment Resistant Bipolar Depression (TRBD) is a major contributor to the burden of disease associated with Bipolar Disorder (BD). Treatment options for people experiencing bipolar depression are limited to three ...
Melatonin In Acute Mania Investigation (MIAMI‐UK). A randomised controlled trial of add‐on melatonin in bipolar disorder
(2020-05)
Objectives
Current options for treating emergent episodes of hypomania and mania in bipolar disorder are limited. Our objective was to compare the effectiveness and safety of add‐on melatonin in hypomania or mania over ...
Plasma glutathione suggests oxidative stress is equally present in early- and late- onset bipolar disorder
(2018-03)
We previously demonstrated oxidative stress in bipolar patients and a
relationship between the age of illness onset and total glutathione, a principal antioxi-
dant. In this study, we sought to replicate these findings ...