Browsing Conditions by Subject "Cognition"
Now showing items 1-20 of 20
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Anticipatory Pleasure in Current Psychosis: Cognitive and Emotional Correlates
(2020-12)Anticipation of pleasure – a key aspect of hedonic experience - is a motivating factor for engaging in activities. Low levels of anticipatory pleasure and activity are found in individuals with psychosis. Cognitive factors ... -
Can dietary supplements maintain cognition in mid- to late-life?
(2020-12)Cognitive health, and prevention of its decline to dementia, has risen in prominence with a corresponding exploration of modifiable risk factors to prevent a decline in cognitive health with age. This commentary discusses ... -
Catechol-O-methyltransferase activity does not influence emotional processing in men
(2022-04)Background: Catechol-O-methyltransferase (COMT) regulates cortical dopaminergic transmission and prefrontal-dependent cognitive function. However, its role in other cognitive processes, including emotional processing, is ... -
Cognition in Mood Disorders
(2020-01)Mood disorders are common, complex, and one of the main causes of morbidity worldwide (1). There has been an increasing recognition that cognitive dysfunction is a central aspect of most mood disorders, as well as being ... -
Cognitive Impairment in Patients with Bipolar Disorder: Impact of Pharmacological Treatment
(2019-12)Bipolar disorder is an illness characterised by periods of elated and depressed mood. These mood episodes are associated with changes in cognitive function and there is evidence to suggest that cognitive dysfunction persists ... -
Cognitive Performance, Quality and Quantity of Movement Reflect Psychological Symptoms in Adolescents
(2020-05)The presentation of unhealthy psychological symptoms are rising sharply in adolescents. Detrimental lifestyle behaviours are proposed as both possible causes and consequences. This study set out to compare selected ... -
Early- and subsequent- response of cognitive functioning in Alzheimer's disease: Individual-participant data from five pivotal randomized clinical trials of donepezil
(2022-02)The association between early improvement and subsequent change in cognition is unexamined in antidementia clinical trials. We aimed to examine the consequences of early-response to antidementia medication in Alzheimer's ... -
Effect of trazodone on cognitive decline in people with dementia: Cohort study using UK routinely collected data
(2021-09)Evidence in mouse models has found that the antidepressant trazodone may be protective against neurodegeneration. We therefore aimed to compare cognitive decline of people with dementia taking trazodone with those taking ... -
Kalirin as a Novel Treatment Target for Cognitive Dysfunction in Schizophrenia
(2021-12)The cognitive dysfunction experienced by patients with schizophrenia represents a major unmet clinical need. We believe that enhancing synaptic function and plasticity by targeting kalirin may provide a novel means to ... -
Linking the Mini-Mental State Examination, the Alzheimer’s Disease Assessment Scale–Cognitive Subscale and the Severe Impairment Battery: evidence from individual participant data from five randomised clinical trials of donepezil
(2020-10)Background The Mini-Mental State Examination (MMSE), the Alzheimer’s Disease Assessment Scale–Cognitive Subscale (ADAS-Cog) and the Severe Impairment Battery (SIB) are widely used rating scales to assess cognition in ... -
Longitudinal cognitive performance in patients with Bipolar Disorder
(2020-01)Commentary: Neurocognitive impairments are a rather common occurrence in euthymic Bipolar Disorder (BD) patients. Understanding the degree of longitudinal stability of these deficits is vital in the management and treatment ... -
Negative bias in interpretation and facial expression recognition in late life depression: A case control study.
(2021-04)While cognitive bias in younger adults with depression has been extensively researched, there have been relatively few investigations of the presence of cognitive bias in late life depression (LLD). This exploratory study ... -
Patient and stakeholder engagement on the role that Social Prescribing might play in supporting the health and wellbeing of people diagnosed with Mild Cognitive Impairment
(2022-11)There is no standardised clinical care for people with mild cognitive impairment (MCI) postdiagnosis. Social prescribing could potentially address this gap, as it enables people to access a range of non-clinical organisations ... -
Personalised treatment for cognitive impairment in dementia: development and validation of an artificial intelligence model
(2022-02)Donepezil, galantamine, rivastigmine and memantine are potentially effective interventions for cognitive impairment in dementia, but the use of these drugs has not been personalised to individual patients yet. We examined ... -
Precision biomarkers for mood disorders based on brain imaging
(2020-10)Mood disorders are a global public health problem because of their high prevalence, chronicity, and recurrence throughout the lifespan as well as increased risk of mortality.123 They also impose a heavy economic burden on ... -
Quantifying the heterogeneity of cognitive functioning in Alzheimer’s disease to extend the placebo-treatment dichotomy: Latent class analysis of individual-participant data from five pivotal randomized clinical trials of donepezil
(2021-02)Background. The extent and profiles of heterogeneity in cognitive functioning among participants in clinical trials of antidementia medication are unknown. We aimed to quantify and identify profiles of heterogeneity of ... -
Severity of Post-Stroke Cognitive Impairment Moderates the Relationship Between Cognitive Change and Emotional Distress in the Months Following Stroke
(2021-09)Depression and anxiety are common psychological consequences of stroke. Here, we investigated the relationships between cognitive change following stroke, awareness of cognitive impairments, and mood to further understanding ... -
A single administration of ‘microbial’ D-alanine to healthy volunteers augments reaction to negative emotions: a comparison with D-serine
(2020-03)Background Activation of the glutamate N-methyl-D-Aspartate receptor (NMDAR) with its co-agonist D-serine has been shown to improve subjective mood in healthy volunteers. D-alanine is another potent NMDAR co-agonist which ... -
Translating the promise of 5HT4 receptor agonists for the treatment of depression
(2020-02)Animal experimental studies suggest that 5-HT4 receptor activation holds promise as a novel target for the treatment of depression and cognitive impairment. 5-HT4 receptors are postsynaptic receptors that are located in ... -
Validation of the UK English Oxford Cognitive Screen-Plus in Sub-Acute and Chronic Stroke Survivors.
(2022-06)Stroke survivors are routinely screened for cognitive impairment with tools that often fail to detect subtle impairments. The Oxford Cognitive Screen-Plus (OCS-Plus) is a brief tablet-based screen designed to detect subtle ...