Browsing Conditions by Author "Harmer, Catherine J"
Now showing items 21-40 of 50
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An Experimental Medicine Investigation of the Effects of Subacute Pramipexole Treatment on Emotional Information Processing in Healthy Volunteers
Halahakoon, Don Chamith; Browning, Michael; Cowen, Philip J; Harmer, Catherine J (2021-08)Treatment with the dopamine D2/D3 receptor agonist pramipexole has demonstrated promising clinical effects in patients with depression. However, the mechanisms through which pramipexole might alleviate depressive symptoms ... -
Glucocorticoid ultradian rhythmicity differentially regulates mood and resting state networks in the human brain: A randomised controlled clinical trial
Harmer, Catherine J (2021-02)Adrenal glucocorticoid secretion into the systematic circulation is characterised by a complex rhythm, composed of the diurnal variation, formed by changes in pulse amplitude of an underlying ultradian rhythm of short ... -
How representative are neuroimaging samples? Large-scale evidence for trait anxiety differences between MRI and behaviour-only research participants.
Pulcu, Erdem; Murphy, Susannah E; Kaltenboeck, Alexander; Browning, Michael; Harmer, Catherine J (2020-04)Over the past three decades, MRI has become a key tool to study how cognitive processes are implemented in the human brain. However, the question of whether participants recruited into MRI studies differ from participants ... -
How women with and without eating disorders perceive their own and others’ bodies: a case-control study
Harmer, Catherine J (University of Bristol, 2020-03)Background: Body dissatisfaction is a key part of the psychopathology of eating disorders, but there is a lack of consensus as to whether the dissatisfaction arises from misperception of body size, and if such misperception ... -
The knowns and unknowns of SSRI treatment in young people with depression and anxiety: efficacy, predictors, and mechanisms of action
Murphy, Susannah E; Capitao, Liliana; Cowen, Philip J; Harmer, Catherine J (2021-08)The use of SSRIs for the treatment of depression and anxiety in young people is increasing. However, the effects of SSRIs in adolescence, a time when there are substantial changes in neural, cognitive, and social functioning, ... -
Lithium modulates striatal reward anticipation and prediction error coding in healthy volunteers
Volman, Inge; Browning, Michael; Cowen, Philip J; Harmer, Catherine J (2020-10)Lithium is one of the most effective mood-stabilizing medications in bipolar disorder. This study was designed to test whether lithium administration may stabilize mood via effects on reward processing. It was hypothesized ... -
Machine learning prediction will be part of future treatment of depression
Harmer, Catherine J (2023-02)Machine learning (ML) is changing the way that medicine is practiced. While already clinically utilised in diagnostic radiology and outcome prediction in intensive care unit, ML approaches in psychiatry remain nascent. ... -
Neural effects of a single dose of fluoxetine on resting-state functional connectivity in adolescent depression
Capitao, Liliana; Chapman, Robert; Wright, Lucy C; Murphy, Susannah E; James, Anthony; Cowen, Philip J; Harmer, Catherine J (2020-11)Fluoxetine is commonly prescribed in adolescent depression, but the neural mechanisms underlying its action remain poorly understood. Here, we used resting-state functional magnetic resonance imaging to investigate the ... -
Neurocognitive processes in d-cycloserine augmented single-session exposure therapy for anxiety: A randomized placebo-controlled trial
Browning, Michael; Harmer, Catherine J (2020-06)Drugs targeting N-methyl-d-aspartate (NMDA) receptors and the ability to learn new associations have been proposed as adjunct treatments to boost the success of exposure therapy for anxiety disorders. However, the effects ... -
No antidepressant-like acute effects of bright light on emotional information processing in healthy volunteers
Harmer, Catherine J; Zghoul, Tarek; Cowen, Philip J (2021-11)Rationale: Bright light treatment (BLT) is an efficacious antidepressant intervention, but its mechanism of action is not well understood. Antidepressant drugs acutely affect how emotional information is processed, pushing ... -
No Association Between Amygdala Responses to Negative Faces and Depressive Symptoms: Cross-Sectional Data from 28,638 Individuals in the UK Biobank Cohort
Harmer, Catherine J; Tamm, Sandra (2022-07)In this Priority Data Letter, we report on the largest study to date to test the association between amygdala reactivity and depressive symptoms based on UK Biobank data. For transparency, we initially set out to investigate ... -
Over-the-counter analgesics use is associated with pain and psychological distress among adolescents: a mixed effects approach in cross-sectional survey data from Norway
Harmer, Catherine J (2021-11)Over-the-counter analgesics (OTCA) such as Paracetamol and Ibuprofen are frequently used by adolescents, and the route of administration and access at home allows unsupervised use. Psychological distress and pain occur ... -
The Oxford study of Calcium channel Antagonism, Cognition, Mood instability and Sleep (OxCaMS): study protocol for a randomised controlled, experimental medicine study
Atkinson, Lauren Z; Colbourne, Lucy; Smith, Alexander L W; Harmer, Catherine J; Nobre, Anna C; Rendell, Jennifer; Jones, Helen; Hinds, Christopher; Mould, Arne; Tunbridge, Elizabeth; Cipriani, Andrea (2019-02)Background: The discovery that voltage-gated calcium channel genes such as CACNA1C are part of the aetiology of psychiatric disorders has rekindled interest in the therapeutic potential of L-type calcium channel (LTCC) ... -
Pramipexole Enhances Reward Learning by Preserving Value Estimates
Halahakoon, Don Chamith; Geddes, John R; Cowen, Philip J; Harmer, Catherine J; Browning, Michael (2022-01)Background: Dopamine D2-like receptor agonists show promise as treatments for depression. They are thought to act by altering how individuals learn from rewarding experiences. However, the nature of these reward learning ... -
Precision biomarkers for mood disorders based on brain imaging
Capitao, Liliana; Harmer, Catherine J (2020-10)Mood disorders are a global public health problem because of their high prevalence, chronicity, and recurrence throughout the lifespan as well as increased risk of mortality.123 They also impose a heavy economic burden on ... -
Predicting treatment response in depression: the role of anterior cingulate cortex
Godlewska, Beata R; Browning, Michael; Cowen, Philip J; Harmer, Catherine J (2018)Background: Identification of biomarkers predicting therapeutic outcome to antidepressant treatment is one of the most important tasks in current research because it may transform the lengthy process of finding the right ... -
Predicting Treatment Response to Antidepressant Medication Using Early Changes in Emotional Processing.
Browning, Michael; Goodwin, Guy M; Harmer, Catherine J (2019-01)Antidepressants must be taken for weeks before response can be assessed with many patients not responding to the first medication prescribed. This often results in long delays before effective treatment is started. ... -
Pro-dopaminergic pharmacological interventions for anhedonia in depression: protocol for a living systematic review of human and non-human studies
Ostinelli, Edoardo; Browning, Michael; Cipriani, Andrea; Harmer, Catherine J (2023-10)Anhedonia is a key symptom of depression, and it has been suggested as a potential target for future individualised treatments. However, much is unknown about how interventions enhancing dopaminergic pathways may affect ... -
Resting state functional connectivity patterns as biomarkers of treatment response to escitalopram in patients with major depressive disorder
Harmer, Catherine J; Godlewska, Beata R (2021-09)With no available response biomarkers, matching an appropriate antidepressant to an individual can be a lengthy process. Improving understanding of processes underlying treatment responsivity in depression is crucial for ... -
A single administration of ‘microbial’ D-alanine to healthy volunteers augments reaction to negative emotions: a comparison with D-serine
Capitao, Liliana; Harmer, Catherine J (2020-03)Background Activation of the glutamate N-methyl-D-Aspartate receptor (NMDAR) with its co-agonist D-serine has been shown to improve subjective mood in healthy volunteers. D-alanine is another potent NMDAR co-agonist which ...